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AMP sensing by DEAD-box RNA helicases.

Abstract：

:In eukaryotes, cellular levels of adenosine monophosphate (AMP) signal the metabolic state of the cell. AMP concentrations increase significantly upon metabolic stress, such as glucose deprivation in yeast. Here, we show that several DEAD-box RNA helicases are sensitive to AMP, which is not produced during ATP hydrolysis by these enzymes. We find that AMP potently inhibits RNA binding and unwinding by the yeast DEAD-box helicases Ded1p, Mss116p, and eIF4A. However, the yeast DEAD-box helicases Sub2p and Dbp5p are not inhibited by AMP. Our observations identify a subset of DEAD-box helicases as enzymes with the capacity to directly link changes in AMP concentrations to RNA metabolism.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Putnam AA,Jankowsky E

doi

10.1016/j.jmb.2013.05.006

subject

Has Abstract

pub_date

2013-10-23 00:00:00

pages

3839-45

issue

20

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(13)00305-7

journal_volume

425

pub_type

杂志文章

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