Abstract：
:It has been proposed that the subthalamic nucleus (STN) mediates response inhibition and conflict resolution through the fronto-basal ganglia pathways. Our aim was to compare the effects of deep brain stimulation (DBS) of the STN on reactive and proactive inhibition and conflict resolution in Parkinson's disease using a single task. We used the conditional Stop signal reaction time task that provides the Stop signal reaction time (SSRT) as a measure of reactive inhibition, the response delay effect (RDE) as a measure of proactive inhibition and conflict-induced slowing (CIS) as a measure of conflict resolution. DBS of the STN significantly prolonged SSRT relative to stimulation off. However, while the RDE measure of proactive inhibition was not significantly altered by DBS of the STN, relative to healthy controls, RDE was significantly lower with DBS off but not DBS on. DBS of the STN did not alter the mean CIS but produced a significant differential effect on the slowest and fastest RTs on conflict trials, further prolonging the slowest RTs on the conflict trials relative to DBS off and to controls. These results are the first demonstration, using a single task in the same patient sample, that DBS of the STN produces differential effects on reactive and proactive inhibition and on conflict resolution, suggesting that these effects are likely to be mediated through the impact of STN stimulation on different fronto-basal ganglia pathways: hyperdirect, direct and indirect.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Obeso I,Wilkinson L,Rodríguez-Oroz MC,Obeso JA,Jahanshahi Mdoi
10.1007/s00221-013-3457-9subject
Has Abstractpub_date
2013-05-01 00:00:00pages
451-62issue
3eissn
0014-4819issn
1432-1106journal_volume
226pub_type
杂志文章abstract：:Previous studies have shown that the "synaptic" bodies of mammalian pinealocytes are a heterogeneous group of organelles. Whereas "synaptic" ribbons (SR) exhibit a day/night rhythm with small numbers during daytime and high numbers at night, the so-called "synaptic" spherules (SS) show species-specific differences in ...
journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
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abstract：:A wealth of evidence implicates the crossed descending projection from the superior colliculus (SC) in orientation and approach behaviours directed towards novel, non-noxious stimuli. In our preceding paper, we identified a population of nociceptive neurones in the rat SC that have axons that project to the contralate...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231781
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abstract：:Anticipatory pursuit is not exclusively based on the recent history of target motion ("temporal anticipation"): it can also use static visual cues ("non-temporal anticipation"). Large non-temporal anticipatory changes of the direction of smooth pursuit are observed when the future trajectory of the target can be infer...
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doi：10.1007/s00221-009-1840-3
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journal_title：Experimental brain research
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050727
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235707
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journal_title：Experimental brain research
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journal_title：Experimental brain research
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231132
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2000-08-01 00:00:00
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4486-3
更新日期：2016-02-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-013-3416-5
更新日期：2013-04-01 00:00:00
abstract：:The spike trains of X and Y retinal ganglion cell axons and neurons in the lateral geniculate nucleus (LGN) of cats were compared to determine if the visual signal could be better discriminated from the maintained activity in the LGN relative to the retina. Curves for relative or receiver operating characteristics (RO...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248364
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journal_title：Experimental brain research
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journal_title：Experimental brain research
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abstract：:Deficits in postural control are one of the hallmarks of disability in children with cerebral palsy (CP). Yet, much remains unknown regarding the etiology of postural deficits in these children. Here we evaluated postural control at a simplified task level by measuring head stability during quiet sitting while systema...
journal_title：Experimental brain research
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journal_title：Experimental brain research
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pub_type： 杂志文章,评审
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journal_title：Experimental brain research
pub_type： 杂志文章,评审
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