Abstract：
:In this study the protective effect of phlorotannins, including phloroglucinol, eckol, dieckol, eckstolonol and triphloroethol A, isolated from brown algae Ecklonia cava was investigated against AAPH-induced oxidative stress toxicity in zebrafish embryos. Zebrafish embryos were exposed to AAPH and compared with other groups that were co-exposed with phlorotannins until 2-days post-fertilisation. All phlorotannins scavenged intracellular ROS and prevented lipid peroxidation and reduced AAPH-induced cell death in zebrafish embryos. Negative changes in morphological phenomena, such as pericardial oedema, yolk sac oedema, and growth retardation in zebrafish embryos exposed to AAPH were not observed in groups exposed to phlorotannins. These results clearly indicate that phlorotannins possess prominent antioxidant activity against AAPH-mediated toxicity and might be potential therapeutic agents for treating or preventing several diseases implicated with oxidative stress. This study provides a useful tool for examining the protective effect of antioxidants against AAPH-induced oxidative stress in an alternative in vivo model.
journal_name
Food Chemjournal_title
Food chemistryauthors
Kang MC,Cha SH,Wijesinghe WA,Kang SM,Lee SH,Kim EA,Song CB,Jeon YJdoi
10.1016/j.foodchem.2012.11.005subject
Has Abstractpub_date
2013-06-01 00:00:00pages
950-5issue
2-3eissn
0308-8146issn
1873-7072pii
S0308-8146(12)01606-8journal_volume
138pub_type
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