Abstract:
:Atrazine (ATZ) is a widely used herbicide and is considered an endocrine disruptor of different organisms. However, the molecular interactions of ATZ with biological targets in mammalian endocrine systems are not understood fully. In the present study, we observed that ATZ administration (50, 100 and 200 mg/kg) for 3 weeks to peripubertal male ICR mice exerted adverse effects on several physiological features; these effects included a significant decrease in the body and liver weights and an increase in the relative testis weight. In addition, the serum testosterone (T) concentration was significantly decreased in all ATZ-treated mice, and the serum estradiol (E2) concentration and aromatase activity were significantly increased in mice exposed to 100 and 200 mg/kg ATZ. These results suggest that ATZ exposure affected hormone homeostasis in male mice. We also found that the transcript levels of the steroidogenic enzyme genes p450scc, p450 17α1 and 17β-HSD were significantly reduced in the testes of mice exposed to 100 and 200 mg/kg ATZ for 3weeks. Given the results of the present study and previous reports, it is possible that ATZ reduces the T concentration in peripubertal male mice by affecting the transcription of steroidogenic genes, such as p450scc, p450 17a1 and 17β-HSD. This study provides new insights into the mammalian toxicological mechanism of ATZ.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Jin Y,Wang L,Fu Zdoi
10.1016/j.ygcen.2013.01.010subject
Has Abstractpub_date
2013-04-01 00:00:00pages
120-7eissn
0016-6480issn
1095-6840pii
S0016-6480(13)00050-6journal_volume
184pub_type
杂志文章abstract::The effects of a long term partial food restriction were studied in chickens and rats. In chickens the treatment resulted in increased plasma T4 levels while T4 levels in rats remained unchanged. Plasma T3 decreased in both species. In vitro hepatic outer ring deiodinating type I (ORD-I) activity was not influenced by...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1995.1164
更新日期:1995-12-01 00:00:00
abstract::The neuropeptide gonadotropin-releasing hormone (GnRH) plays an important role in the control of reproductive functions. Vertebrates possess multiple GnRH isoforms that are classified into three main groups, namely GnRH1, GnRH2 and GnRH3. In the present study, we show that the chromosomal organization of the three GnR...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2010.11.017
更新日期:2011-02-01 00:00:00
abstract::Interrenal activity in relation to sexual maturity in male rainbow trout, and the effects of in vivo treatment with 11-ketotestosterone (11-KT) were investigated. Silastic pellets containing either 11-KT or no steroid were implanted in maturing male and immature male and female rainbow trout for a total of 11 weeks. T...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1996.0125
更新日期:1996-09-01 00:00:00
abstract::Previous data have shown that regional differences in the presence of anterior pituitary luteinizing hormone (LH) generally correlate with the comparable disparities in distribution of gonadotropes throughout the gland. In female rats, the differences are apparent over the estrous cycle, but are more prominent during ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2008.02.015
更新日期:2008-05-01 00:00:00
abstract::Chemical signals (both volatile and non-volatile) form the major communication channels in animals. These signals are transferred mainly through excretory sources to facilitate inter-individual communication. In particular, the reproductive cycle of female mammals, including goats, exhibits significant changes in the ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2014.07.028
更新日期:2014-09-15 00:00:00
abstract::Two aspects of hormonal control of aggressive territorial behavior in male mountain spiny lizards Sceloporus jarrovi were studied. First, testosterone (T) implants were given to free-living castrated males during the breeding season. These implants fully restored breeding season levels of aggressive and sexual behavio...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(88)90121-9
更新日期:1988-06-01 00:00:00
abstract::We investigated the effect of several potential carbohydrate secretagogues, amino acids, a ketoacid, and potassium chloride on insulin, glucagon, and somatostatin release from the in vitro perfused Brockmann body of channel catfish (Ictalurus punctatus). Mannose (15 mM) stimulated the release of insulin and somatostat...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(87)90120-1
更新日期:1987-03-01 00:00:00
abstract::Steelhead and hybrid trout (rainbow trout male, steelhead female) presmolts and smolts, Oncorhynchus mykiss, exposed to 30/1000 seawater (SW) for 24 hr manifested progressively lower plasma sodium values from December to May. The increase in plasma sodium after 24 hr in SW diminished significantly after March, with th...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1994.1012
更新日期:1994-01-01 00:00:00
abstract::Testosterone has been suggested to be involved in the regulation of male territorial behavior. For example, seasonal peaks in testosterone typically coincide with periods of intense competition between males for territories and mating partners. However, some species also express territorial behavior outside a breeding...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2012.11.027
更新日期:2013-04-01 00:00:00
abstract::Cytochalasin B (CB) and the more specific cytochalasin D (CD), disruptors of microfilament polymerization, and colchicine, an inhibitor of microtubule polymerization, were studied for their effects on cAMP and steroid production in granulosa cells of domestic fowl. Each agent was incubated with freshly dispersed cells...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(91)90310-3
更新日期:1991-06-01 00:00:00
abstract::The phenomenon of musth is a very stressful event, both behaviorally and physiologically. An ACTH stimulation test was conducted in four adult Asian bull elephants to investigate the possibility that the classical hypothalamic-pituitary-adrenal (HPA) axis is active during musth, resulting in an increase in adrenally p...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2007.01.029
更新日期:2007-05-01 00:00:00
abstract::Pregnancy and lactation are key times in the life of female mammals when energetic resources must be brought to bear to produce and nurture offspring. Changes in glucocorticoid (GC) levels are central to this objective, due to their roles in modulating development and physiology and in mediating energetic tradeoffs. W...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2015.11.004
更新日期:2016-06-01 00:00:00
abstract::Androgens take part in the regulation of puberty and promote growth and development. They play their biological role by binding to a specific androgen receptor (AR). The aim of this study was to evaluate the expression of AR mRNA and protein in the pituitary and adrenal glands, to localize AR protein in luteinizing ho...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2015.03.001
更新日期:2015-06-01 00:00:00
abstract::The rainbow trout (Oncorhynchus mykiss) ovarian gonadotropin (GTH II) receptor was solubilized by extraction with the nonionic detergent 1% Triton X-100 in the presence of 20% glycerol. The hormone-binding characteristics of the soluble receptors were similar to those of membrane-bound receptors: the Scatchard plot of...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1993.1127
更新日期:1993-09-01 00:00:00
abstract::The Atlantic Bluefin Tuna (ABFT, Thunnus thynnus) is one of the most intensely exploited fisheries resources in the world. In spite of the years of studies on ABFT, basic aspects of its reproductive biology remain uncertain. To gain insight regarding the seasonal changes of the reproductive characteristics of the east...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2019.113216
更新日期:2019-10-01 00:00:00
abstract::1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the hormonally active metabolite of vitamin D3 interacts with its nuclear/cytosolic receptor to induce biological responses in target tissues. Naked mole rats appear to be naturally deficient in vitamin D. The questions arise whether these animals possess the 1,25(OH)2D3 recepto...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1993.1089
更新日期:1993-06-01 00:00:00
abstract::For grass carp (Ctenopharyngodon idella) raised in the Ivory Coast (with water temperatures of 26-31 degrees C), induced spawning is obligatory for fry production. However, ovulation rates following hormonal treatment are often low. We hypothesized that high temperatures are an inhibiting factor for the reproductive a...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2003.12.009
更新日期:2004-04-01 00:00:00
abstract::Intraperitoneal injection of CaCl2 in intact, sham-stanniectomized, and stanniectomized American eels, Anguilla rostrata (LeSueur), resulted in a rapid elevation of plasma calcium level which was more marked and of longer duration in the stanniectomized eels. The same treatment reduced whole body calcium influx (JinCa...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(91)90321-v
更新日期:1991-06-01 00:00:00
abstract::In insects, especially phytophagous insects, feeding behavior occurs at a regular frequency. Although a number of physiological studies have revealed various causal factors leading to feeding behavior in insects, little has been demonstrated regarding the regulatory mechanisms underlying insect feeding behavior. To co...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2011.03.004
更新日期:2011-05-15 00:00:00
abstract::Follicle-stimulating hormone (FSH) stimulates aromatase activity of immature rat Sertoli cells cultured in vitro in the presence of an androgen substrate, a phenomenon that can be used to measure FSH bioactivity. This paper analyzes the effects of sera from various animal species on both aromatase activity and morphol...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1994.1106
更新日期:1994-07-01 00:00:00
abstract::We investigated the development of thyroid function during the transition to endothermy in red-winged blackbirds (Agelaius phoeniceus). Thermoregulatory capabilities of blackbirds improve markedly over their relatively short nestling period (10-12 days), with the most striking improvements occurring between days 6 and...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1999.7363
更新日期:1999-11-01 00:00:00
abstract::Dihydrotestosterone (DHT) and 17β-estradiol (E2) are sex hormones that regulate human hair follicle (HF) growth and are produced by peripheral reduction and aromatization of testosterone. However, the expression patterns of DHT and E2 synthesis-related proteins and their receptors in male yak skin during different HF ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2019.113245
更新日期:2020-01-15 00:00:00
abstract::This paper describes changes in the content of free steroid hormones e.g. testosterone (T), estradiol-17β (E2), estrone (E1) and estriol (E3) of Mytilus trossulus from the southern Baltic Sea as a function of season, stage of gametogenesis, sex, tissue (gonadal and somatic) and depth. The highest levels of T, E2, E1 a...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2017.12.006
更新日期:2018-04-01 00:00:00
abstract::The regulation of rainbow trout prolactin (PRL) cells by hypothalamic and humoral factors has been investigated. PRL cell activity was assessed using acid gel electrophoresis to measure PRL release in vitro and image analysis to measure PRL cell nuclear area, an index of synthetic activity. 17 beta-oestradiol stimulat...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1994.1043
更新日期:1994-03-01 00:00:00
abstract::This experiment was performed on two groups of male Japanese quail. One had been maintained in our laboratory as a closed colony (S-group), and the other had been obtained from a commercial source (R-group). Different responses of gonadal function were found between two groups following either testosterone treatment o...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(85)90390-9
更新日期:1985-09-01 00:00:00
abstract::Plasma progesterone concentrations were measured every 2 or 3 days in eastern quoll, Dasyurus viverrinus, during pregnancy (20.5 +/- 0.8 days, n = 6, mean +/- SEM) and the estrous cycle (37.5 +/- 0.7 days, n = 20, mean +/- SEM). The pattern was not apparently different between the two reproductive states. There was a ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(89)90015-4
更新日期:1989-07-01 00:00:00
abstract::Optimization of food consumption and ultimately growth are major concerns for aquaculture. In fish, food intake is regulated by several hormones produced by both brain and peripheral tissues. Changes in feeding behavior and appetite usually occur through the modulation of the gene expression and/or action of these app...
journal_title:General and comparative endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.ygcen.2009.09.001
更新日期:2010-07-01 00:00:00
abstract::The presence and distribution of cholecystokinin (CCK)/gastrin-like immunoreactivity (IR) was examined in the goldfish pituitary. Intense CCK/gastrin-like IR was consistently observed within fibers of the proximal pars distalis (PD), with fewer IR fibers localized in the rostral PD. Within the proximal PD CCK/gastrin-...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1993.1146
更新日期:1993-10-01 00:00:00
abstract::In mammals, downstream function of the nuclear progestin receptor (PGR) can be differentially regulated in each target tissue by altering the expression levels of PGR mRNA variants. Such PGR isoforms have also been identified in birds and reptiles, but not in non-amniote vertebrates. Based upon extensive phylogenetic,...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2012.11.015
更新日期:2013-02-01 00:00:00
abstract::Plasma concentrations of stress hormones [adrenaline (ADR), noradrenaline (NR)], lactate, glucose and CO2 were monitored during peak nesting period (May-October) at different phases of nesting in the green turtle, Chelonia mydas. These include, emergence from sea, excavating body and nest chambers, oviposition, coveri...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2007.09.012
更新日期:2008-02-01 00:00:00