Partial food restriction increases hepatic inner ring deiodinating activity in the chicken and the rat.

Abstract:

:The effects of a long term partial food restriction were studied in chickens and rats. In chickens the treatment resulted in increased plasma T4 levels while T4 levels in rats remained unchanged. Plasma T3 decreased in both species. In vitro hepatic outer ring deiodinating type I (ORD-I) activity was not influenced by the food restriction, suggesting that the amount of ORD-I enzyme present in the liver remained unchanged. In vitro hepatic inner ring deiodinating type III activity, on the contrary, was greatly increased in both species. This increase may contribute to the decreased circulating T3 levels by increasing the degradation of T3 and diverting the deiodination of T4 to rT3 instead of to T3.

journal_name

Gen Comp Endocrinol

authors

Darras VM,Cokelaere M,Dewil E,Arnouts S,Decuypere E,Kühn ER

doi

10.1006/gcen.1995.1164

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

334-8

issue

3

eissn

0016-6480

issn

1095-6840

pii

S0016-6480(85)71164-1

journal_volume

100

pub_type

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