Hypothalamic hamartomas: neuropathological features with and without prior gamma knife radiosurgery.

Abstract:

BACKGROUND:The neuropathological consequences of Gamma Knife radiosurgery (GK) on hypothalamic hamartoma (HH) are unknown. OBJECTIVE:In a cohort of patients undergoing surgery for treatment-resistant epilepsy, we compared surgically resected HH tissue from patients without (group I; n = 19) and with (group II; n = 10) a history of GK (median dose 16 Gy to the 50% isodose margin). METHODS:Techniques included thick-section stereology for total nucleated and total neuron cell counts, and thin-section immunohistochemistry. Normal human hypothalamus derived from age-matched autopsy material was used as control tissue for CD68 immunohistochemistry. Qualitative scoring of tissue sections was performed by a neuropathologist who was blind to the GK treatment history. RESULTS:GK is associated with decreased total cell density (p < 0.02). A dose-dependent association of GK with decreased total neuron density approached significance (p = 0.06). Group II HH tissue had significantly more (1) reactive gliosis, (2) thickened capillary endothelium and (3) microglial activation. Degenerative features, including karyorrhexis and pyknotic nuclei, were infrequent in group II and absent in group I HH tissue. CONCLUSIONS:Nonnecrotizing doses of GK radiosurgery decrease cell density in human HH tissue. Cell loss resulting from GK may contribute to decreased excitation in the neuronal networks responsible for seizure onset in HH tissue.

authors

Kerrigan JF,Parsons A,Rice SG,Simeone K,Shetter AG,Abla AA,Prenger E,Coons SW

doi

10.1159/000341076

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

45-55

issue

1

eissn

1011-6125

issn

1423-0372

pii

000341076

journal_volume

91

pub_type

杂志文章
  • Gamma knife radiosurgery for refractory epilepsy caused by hypothalamic hamartomas.

    abstract:BACKGROUND:Hypothalamic hamartomas are associated with precocious puberty and chronic epilepsy characterized by gelastic seizures. The seizure disorder is usually refractory to most antiepileptic drugs. Gamma knife surgery has emerged as an alternative to microsurgical removal or radiofrequency ablation to improve seiz...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000094036

    authors: Mathieu D,Kondziolka D,Niranjan A,Flickinger J,Lunsford LD

    更新日期:2006-01-01 00:00:00

  • Functional neurosurgery--a future for the gamma knife?

    abstract::The Gamma Knife is currently the only radiosurgical device which has been used in functional neurosurgery. This mode of utilization is possible because the instrument can make lesions in normal brains with a volume as small as 50 mm3. The experience of functional radiosurgery accumulated at the Karolinska Institute ov...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000099557

    authors: Lindquist C,Kihlström L,Hellstrand E

    更新日期:1991-01-01 00:00:00

  • Bilateral cingulotomy and anterior capsulotomy applied to patients with aggressiveness.

    abstract:OBJECTIVE:To perform a preliminary study on the effects and safety of bilateral cingulotomy and anterior capsulotomy in patients with aggressive behavior. PATIENTS AND METHODS:Twenty-three psychiatric patients showing aggressive behavior refractory to conventional treatment were initially evaluated. The subjects were ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000336746

    authors: Jiménez F,Soto JE,Velasco F,Andrade P,Bustamante JJ,Gómez P,Ramírez Y,Carrillo-Ruiz JD

    更新日期:2012-01-01 00:00:00

  • Longevity of batteries in internal pulse generators used for deep brain stimulation.

    abstract::The longevity of batteries in internal pulse generators (IPGs) used clinically for deep brain stimulation is not known. We conducted a study to assess the life span of these batteries. From 1993 to 2000, 163 single-channel batteries were surgically implanted in our institution. The electrical settings utilized in pati...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000075161

    authors: Bin-Mahfoodh M,Hamani C,Sime E,Lozano AM

    更新日期:2003-01-01 00:00:00

  • Less is more: adaptation of voltage after battery replacement in deep brain stimulation for dystonia.

    abstract:BACKGROUND:To maintain the efficacy of deep brain stimulation (DBS) on dystonic symptoms, slight incremental increase in voltage may be necessary over years after a steady state has been reached following the initial programming of optimal settings. So far however, no data are available regarding the adjustment of volt...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000319958

    authors: Blahak C,Capelle HH,Bäzner H,Kinfe T,Hennerici MG,Krauss JK

    更新日期:2010-01-01 00:00:00

  • Comparative Study of Robot-Assisted versus Conventional Frame-Based Deep Brain Stimulation Stereotactic Neurosurgery.

    abstract:BACKGROUND/AIMS:Technological advancements had a serious impact on the evolution of robotic systems in stereotactic neurosurgery over the last three decades and may turn robot-assisted stereotactic neurosurgery into a sophisticated alternative to purely mechanical guiding devices. OBJECTIVES:To compare robot-assisted ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000494736

    authors: Neudorfer C,Hunsche S,Hellmich M,El Majdoub F,Maarouf M

    更新日期:2018-01-01 00:00:00

  • Successful bilateral subthalamic nucleus stimulation for segmental dystonia after unilateral pallidotomy.

    abstract:BACKGROUND:Several subcortical structures have been targeted for surgical treatment of dystonia, including motor thalamus, internal segment of globus pallidus (GPi), and more recently, the subthalamic nucleus (STN). Deep brain stimulation of GPi is currently the preferred surgical treatment, but it is unclear if target...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000112428

    authors: Novak KE,Nenonene EK,Bernstein LP,Vergenz S,Cozzens JW,Rezak M

    更新日期:2008-01-01 00:00:00

  • Electrical Stimulation of Subiculum for the Treatment of Refractory Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: A 2-Year Follow-Up Study.

    abstract:INTRODUCTION:Evidence has been provided that the subiculum may play an important role in the generation of seizures. Electrical stimulation at this target has been reported to have anticonvulsive effects in kindling and pilocarpine rat models, while in a clinical study of hippocampal deep brain stimulation (DBS), conta...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000510295

    authors: Vázquez-Barrón D,Cuéllar-Herrera M,Velasco F,Velasco AL

    更新日期:2020-10-28 00:00:00

  • Implementation of a stereotactic microscope using an optically coupled tracking system.

    abstract::Image-directed neurosurgical systems allow the correlation of a point in the operative field to a corresponding point on the patient's CT/MR scans. We have modified a surgical microscope by mounting three light-emitting diodes (LEDs) on a small frame attached to the microscope. The operative field was registered to th...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000099675

    authors: Hirschberg H

    更新日期:1996-01-01 00:00:00

  • Paradoxical labeling of radiosurgically treated quiescent tumors with Ki67, a marker of cellular proliferation.

    abstract::Ki67 (also known as MIB) is a monoclonal antibody staining agent, which is routinely used as a marker of cellular proliferation. It is used to evaluate the proliferative potential of malignant tumors, since it is thought to stain only those cells undergoing active division. The paradoxical elevation of the Ki67 labeli...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000056438

    authors: Jennelle R,Gladson C,Palmer C,Guthrie B,Markert J

    更新日期:1999-01-01 00:00:00

  • Rapid method for determination of isocenter of radiation gantry and alignment of laser beams for stereotactic radiosurgery.

    abstract::A simple technique has been designed which identifies the gantry isocenter and aligns the laser beams to the isocenter of the gantry within 3-5 min with an error of less than 0.75 mm, depending upon the accuracy of gantry rotation. ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000099516

    authors: Heifetz MD,Rosemark PJ,Wexler MC,Greenberg SH,Thompson RW

    更新日期:1989-01-01 00:00:00

  • Modified Fluorodeoxyglucose Metabolism in Motor Circuitry by Subthalamic Deep Brain Stimulation.

    abstract:BACKGROUND:Adjustment of the motor circuitry has been described in the treatment of Parkinson disease (PD). OBJECTIVES:To evaluate the modulation of the motor circuitry of PD patients by subthalamic deep brain stimulation (STN DBS) using 18F-fluorodeoxyglucose (FDG) and positron emission tomography (PET). METHODS:Res...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000455930

    authors: Cao C,Zhang H,Li D,Zhan S,Zhang J,Zhang X,Zuo C,Sun B

    更新日期:2017-01-01 00:00:00

  • Interstitial hyperthermia of malignant brain tumors by an implant heating system using stereotactic techniques.

    abstract::Interstitial hyperthermia of malignant brain tumors has been produced by a heated ferromagnetic implant with a low Curie point. Induction heating of the implant, which is stereotactically implanted in a tumor, is obtained by eddy currents in a high-frequency magnetic field. Safe, repeated and long-term treatment of 35...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000098928

    authors: Kobayashi T,Kida Y

    更新日期:1992-01-01 00:00:00

  • Surgical treatment of patients with Rasmussen encephalitis.

    abstract:BACKGROUND:Rasmussen encephalitis (RE) is a rare progressive encephalitis that results in intractable seizures, cognitive decline and hemiparesis. Surgery seems to be the only effective way to control seizures in RE patients. OBJECTIVE:To describe the clinical, electrophysiological, neuroradiological and histological ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000355901

    authors: Guan Y,Zhou J,Luan G,Liu X

    更新日期:2014-01-01 00:00:00

  • Comparison of radiosurgery planning modalities for acoustic neuroma with regard to conformity and mean target dose.

    abstract:PURPOSE:To evaluate dose conformity and mean target dose in light of previous comparative studies and state-of-the-art radiosurgery delivery modalities. MATERIALS AND METHODS:Seven patients with acoustic neuromas deemed clinically suitable for linear accelerator or Gamma Knife radiosurgery were planned such that the m...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000089987

    authors: Perks JR,El-Hamri K,Blackburn TP,Plowman PN

    更新日期:2005-01-01 00:00:00

  • Subthalamic nucleus stimulation does not cause deterioration of preexisting hallucinations in Parkinson's disease patients.

    abstract:BACKGROUND:Among the neuropsychiatric symptoms in Parkinson's disease (PD) patients, hallucination can result from the disease itself or medical treatment. Hallucination associated with subthalamic nucleus stimulation (STN-DBS) has been reported; however, it is still unclear whether PD patients with a history of halluc...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000195719

    authors: Yoshida F,Miyagi Y,Kishimoto J,Morioka T,Murakami N,Hashiguchi K,Samura K,Sakae N,Yamasaki R,Kawaguchi M,Sasaki T

    更新日期:2009-01-01 00:00:00

  • Continuous intrathecal clonidine administration for the treatment of neuropathic pain.

    abstract::In many cases, the treatment of neuropathic pain by intrathecal opioids fails to meet expectations. In a trial involving 10 patients, the intrathecal administration of clonidine combined with opioids in the treatment of chronic pain was introduced in our department for the first time. Eight patients with neuropathic p...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.1159/000048402

    authors: Uhle EI,Becker R,Gatscher S,Bertalanffy H

    更新日期:2000-01-01 00:00:00

  • Percutaneous Foramen Ovale Puncture: Usefulness of Intraoperative CT Control, in the Eventuality of a Narrow Foramen.

    abstract:BACKGROUND:Balloon compression of the gasserian ganglion has been a well-established percutaneous treatment of trigeminal neuralgia since the 1980s. However, puncture of the foramen ovale by conventional single-plane fluoroscopy can be difficult in cases of local anatomic abnormalities. CASE PRESENTATION:We present th...

    journal_title:Stereotactic and functional neurosurgery

    pub_type:

    doi:10.1159/000509821

    authors: Mendes PD,Martins da Cunha PH,Monteiro KKO,Quites LV,Fonseca Filho GA

    更新日期:2020-09-16 00:00:00

  • A prospective, randomized study of spinal cord stimulation versus reoperation for failed back surgery syndrome: initial results.

    abstract::Spinal cord stimulation (SCS) has been reported to be effective treatment for the failed back surgery syndrome in a number of retrospective case series. Its retrospectively reported results compare favorably with those of neurosurgical treatment alternatives, such as reoperation and ablative procedures. There has been...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000098631

    authors: North RB,Kidd DH,Lee MS,Piantodosi S

    更新日期:1994-01-01 00:00:00

  • Interstitial irradiation for CNS lesions.

    abstract::In this study, we investigated the efficacy of brachytherapy in the treatment of 138 patients with intracranial neoplasms of the CNS. Of the total number of patients, 50 presented with glioblastoma multiforme, 45 presented with low-grade glioma, 19 presented with anaplastic astrocytoma, 23 presented with metastases an...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000075100

    authors: Teixeira MJ,Lepski G,Correia C,Aguiar PH

    更新日期:2003-01-01 00:00:00

  • Transplantation of adrenal medullary tissue to caudate nucleus using stereotactic techniques.

    abstract::Stereotactic techniques were used to transplant adrenal medullary tissue to the head of the right caudate nucleus in 12 patients with Parkinson's disease. No significant lasting complications were seen. All patients had an initial improvement. 11 of the 12 patients remain improved over their preoperative condition aft...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000100221

    authors: Gildenberg PL,Pettigrew LC,Merrell R,Butler I,Conklin R,Katz J,DeFrance J

    更新日期:1990-01-01 00:00:00

  • Comparison of MRI and ventriculographic target acquisition for posteroventral pallidotomy.

    abstract::The true accuracy of MRI scanners utilized for target acquisition in functional stereotaxis remains undefined. We have performed pallidotomies at the Loma Linda University Medical Center using both MRI and MRI concomitant with positive contrast ventriculography. A retrospective study of 33 cases revealed significant d...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000098897

    authors: Mandybur G,Morenski J,Kuniyoshi S,Iacono RP

    更新日期:1995-01-01 00:00:00

  • Anatomical Study of Percutaneous Trigeminal Compressive Balloon Positioning on Merged 3-D Rotational X-Ray and Preprocedural Magnetic Resonance Imaging.

    abstract:BACKGROUND:Percutaneous trigeminal rhizotomy or balloon compression for trigeminal neuralgia carries a potential risk for the brainstem, the carotid artery, and the basilar artery. OBJECTIVE:To detail the relation of critical neural and vascular structures to expanded balloons used for percutaneous compression of the ...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000489947

    authors: Sandwell S,Montoya S,Towner JE,Markman JD,Schell MC,Bhalla T

    更新日期:2018-01-01 00:00:00

  • Using Monte-Carlo-simulated radiation transport to calculate dose distribution in rats before irradiation with Leksell Gamma Knife 4C: technical note.

    abstract:BACKGROUND:Gamma knife surgery (GKS) is used at subnecrotic doses for temporal lobe epilepsy (TLE) treatment. Rat models of TLE have been used to probe the mechanisms underlying GKS. Previous GKS studies on rats have used the Leksell GammaPlan (LGP) treatment planning system to determine the irradiation time to achieve...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000314355

    authors: Marcelin B,Kjäll P,Johansson J,Lundin A,Nordström H,Eriksson M,Bernard C,Régis J

    更新日期:2010-01-01 00:00:00

  • Analysis of stereotactic accuracy of the cosman-robert-wells frame and nexframe frameless systems in deep brain stimulation surgery.

    abstract:INTRODUCTION:The primary goal of stereotactic systems in deep brain stimulation (DBS) surgery is accurate delivery of a DBS lead to a target identified on imaging. Thus, it is critical to understand the accuracy of the stereotactic systems and the factors which may be associated with a decrease in accuracy. METHODS:Ni...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000316761

    authors: Kelman C,Ramakrishnan V,Davies A,Holloway K

    更新日期:2010-01-01 00:00:00

  • Lateral orthogonal approach for depth electrode insertion using the Leksell frame: technical note.

    abstract::A simple device is described to perform lateral orthogonal approaches using the Leksell stereotactic frame. This device is especially useful for simultaneous bilateral insertion of intracerebral electrodes without the need for attaching the stereotactic arc. It also allows for targeting of far lateral lesions that lie...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000100610

    authors: Rees Cosgrove G

    更新日期:1993-01-01 00:00:00

  • Exploration of the role of the upper brainstem in motor control.

    abstract::The rostral areas of the brainstem have been extensively studied in higher mammals and to a lesser extent in humans in the last two decades, looking for anatomical, electrophysiological and neurochemical evidence of involvement in the initiation and control of voluntary movement. This has come with the realisation tha...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000068961

    authors: Nandi D,Stein JF,Aziz TZ

    更新日期:2002-01-01 00:00:00

  • Integration of stereoscopic DSA with three-dimensional image reconstruction for stereotactic planning.

    abstract::Following 4 years of experience using a microcomputer-based system for the planning of stereotactic neurosurgery, we have now developed a workstation with the capability of displaying and analyzing three-dimensional images for this purpose. In addition to viewing volumetrically rendered three-dimensional computer tomo...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000100257

    authors: Peters TM,Henri C,Pike GB,Clark JA,Collins L,Olivier A

    更新日期:1990-01-01 00:00:00

  • Using the new clinical grading scale for quantification of the severity of hemifacial spasm: correlations with a quality of life scale.

    abstract:BACKGROUND:To date, no consensus has been reached regarding validated and practical tools to quantify the severity of hemifacial spasm (HFS) before and after surgery. OBJECTIVE:The aim of this study has been to establish objective parameters for determining the preoperative severity of HFS and to assess the correlatio...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000330396

    authors: Lee JA,Jo KW,Kong DS,Park K

    更新日期:2012-01-01 00:00:00

  • Tremor and skeletal muscle tone.

    abstract::Stereotactic interventions at thalamic/subthalamic levels for parkinsonian tremor give the chance to investigate the influence of the supraspinal proprioceptive loops on the tonic component of motor tasks. Studies demonstrate not only a normalization of the late stretch reflex component and a decrease of the pre-refle...

    journal_title:Stereotactic and functional neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000100603

    authors: Struppler A

    更新日期:1993-01-01 00:00:00