Using Monte-Carlo-simulated radiation transport to calculate dose distribution in rats before irradiation with Leksell Gamma Knife 4C: technical note.

Abstract:

BACKGROUND:Gamma knife surgery (GKS) is used at subnecrotic doses for temporal lobe epilepsy (TLE) treatment. Rat models of TLE have been used to probe the mechanisms underlying GKS. Previous GKS studies on rats have used the Leksell GammaPlan (LGP) treatment planning system to determine the irradiation time to achieve the dose to deliver. Since LGP is not designed for such small structures, it is important to calibrate the system for the rat brain. METHODS:We have used a Monte Carlo simulation (MCS) radiation transport scheme, with CT data as anatomical and tissue-specific information, to simulate the dose distribution in a rat brain when using a Leksell Gamma Knife. RESULTS:We show how dose distributions obtained by MCS quantitatively compare to those predicted by LGP, and discuss whether LGP should be used for studies involving rats. The energy deposited when using the 4-mm collimators was calculated for targets on both sides of the rat brain in the dorsal hippocampus, which allowed us to determine the exact time to irradiate rats with a given dose. CONCLUSION:The MCS method used in this study can easily be used for future GKS studies on small animals when accurate dose distributions are required.

authors

Marcelin B,Kjäll P,Johansson J,Lundin A,Nordström H,Eriksson M,Bernard C,Régis J

doi

10.1159/000314355

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

208-15

issue

4

eissn

1011-6125

issn

1423-0372

pii

000314355

journal_volume

88

pub_type

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