Interleukin-11, an interleukin-6-like cytokine, is a promising predictor for bladder cancer prognosis.

abstract：:Autogenous microfat grafting is widely used to augment depressed deformities or for other cosmetic purposes. Since the microfat survival rate is unpredictable due to absorption and calcification, previously cryopreserved fat is widely used for secondary procedures. Sphingosylphosphorylcholine (SPC) is a lysophospholip...

journal_title：Molecular medicine reports

authors： Bae YC,Choi CW,Nam KW,Song JS,Lee JW

更新日期：2016-10-01 00:00:00

abstract：:The present study aimed to discuss and evaluate the diagnostic performances and incremental clinical values of combined computed tomography coronary angiography (CTCA) and single photon myocardial perfusion imaging (MPI) for the detection of functionally relevant coronary stenoses (FRCS). In total, 54 patients underwe...

journal_title：Molecular medicine reports

authors： Li JM,Shi RF,Zhang LR,Li T,Dong Z

更新日期：2013-05-01 00:00:00

abstract：:The high risk of developing colorectal carcinoma (CRC), from ulcerative colitis (UC), is well known. Macrophages are widely distributed immune cells that have an indispensable role in UC, as well as in CRC. However, little is currently known about the dynamic changes that occur in macrophage and M1/M2 macrophage subpo...

journal_title：Molecular medicine reports

authors： Wang W,Li X,Zheng D,Zhang D,Peng X,Zhang X,Ai F,Wang X,Ma J,Xiong W,Li G,Zhou Y,Shen S

更新日期：2015-04-01 00:00:00

abstract：:Breast cancer is the most common type of cancer among females and the adenosine triphosphate (ATP) binding cassette E1 (ABCE1) gene is a member of the ATP‑binding cassette (ABC) family. Studies in lung cancer have shown that overexpression of ABCE1 in tumor cells promotes growth and inhibits apoptosis. However, little...

journal_title：Molecular medicine reports

authors： Huang B,Zhou H,Lang X,Liu Z

更新日期：2014-10-01 00:00:00

abstract：:Multidrug resistance (MDR) in epithelial ovarian cancer (EOC) remains a public health issue for women worldwide, and its molecular mechanisms remain to be fully elucidated. The present study aimed to predict the potential genes involved in MDR, and examine the mechanisms underlying MDR in EOC using bioinformatics tech...

journal_title：Molecular medicine reports

authors： Chen C,Hu Y,Li L

更新日期：2016-01-01 00:00:00

abstract：:The von Hippel‑Lindau (VHL) gene is a tumor suppressor gene, which is widely expressed in the kidney, lung, breast, eye, ovary and cervix. Mutations of the VHL gene are able to induce VHL disease and tumorigenesis. However, it has yet to be evaluated whether the VHL gene is expressed in the human endometrium. The obje...

journal_title：Molecular medicine reports

authors： Lu YY,Zhu WJ,Xie BG

更新日期：2014-04-01 00:00:00

abstract：:Pingyangmycin (PYM), a glycopeptide antibiotic, has been recommended as a stand treatment for hemangioma. However, the underlying mechanisms of its anti‑tumor effects have remained elusive. The purpose of the present study was to explore the effects of PYM on the biological behavior of the EOMA mouse hemangioendotheli...

journal_title：Molecular medicine reports

authors： Peng LX,Zhao P,Zhao HS,Pan E,Yang BB,Li Q

更新日期：2015-12-01 00:00:00

abstract：:Stroke is a leading cause of impairment and disability worldwide, and motor imagery (MI) has been used in stroke rehabilitation. Electroencephalography (EEG) has been used to study MI. However, the characteristic features of EEG during MI in stroke patients have not been established. The purpose of this study was to i...

journal_title：Molecular medicine reports

authors： Gong W,Zhang T,Shan L

更新日期：2013-12-01 00:00:00

abstract：:Ectomesenchymal stem cells (EMSCs) represent a type of adult stem cells derived from the cranial neural crest. These cells are capable of self‑renewal and have the potential for multidirectional differentiation. Tissue transglutaminase type 2 (TG2) is a ubiquitously expressed member of the transglutaminase family of C...

journal_title：Molecular medicine reports

authors： Shi W,Que Y,Lv D,Bi S,Xu Z,Wang D,Zhang Z

更新日期：2019-09-01 00:00:00

abstract：:Retroviral vectors have been considered the most promising vehicles for the transfer of therapeutic genes into cells of the hematopoietic system. In clinical studies, however, cases of leukemoid clonogenic expansion of the transduced cells in vivo caused by semirandom integration of the foreign DNA in the genome have ...

journal_title：Molecular medicine reports

authors： Zehnpfennig D,Deissler H,Polack A,Herr D,Bornkamm GW,Kurzeder C

更新日期：2010-07-01 00:00:00

abstract：:Bone cancer pain (BCP) is a severe complication of advanced bone cancer. Although cannabinoid receptor 2 (CB2) agonists may have an analgesic effect, the underlying mechanism remains unclear. CB2 serves a protective role in various pathological states through the activation of autophagy. Therefore, the present study a...

journal_title：Molecular medicine reports

authors： Mao Y,Huang Y,Zhang Y,Wang C,Wu H,Tian X,Liu Y,Hou B,Liang Y,Rong H,Gu X,Ma Z

更新日期：2019-12-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is commonly considered to occur as a result of disturbance of the immune system. T-box expressed in T cells (T-bet) is an essential transcription factor for T helper (Th) cell differentiation and function. The aim of this study was to investigate the effect of T-bet overexpres...

journal_title：Molecular medicine reports

authors： Liu X,Tang Z,Zhang Y,Hu J,Li D,Zang G,Yu Y

更新日期：2012-08-01 00:00:00

abstract：:Sphincter of Oddi dysfunction (SOD) is a benign obstructive disorder predominantly resulting from spasms of the SO. Pharmacological therapies aim to induce SO relaxation; the hypercholesterolemic (HC) rabbit is the only SOD model available for study. In the present study, SO muscle strips, intracellular calcium ion co...

journal_title：Molecular medicine reports

authors： Wang F,Yang Y,Ji X,Tao X,Wang Y,Wang C

更新日期：2019-06-01 00:00:00

abstract：:Wound healing impairment is increasingly recognized to be a consequence of hyperglycemia‑induced dysfunction of endothelial precursor cells (EPCs) in type 2 diabetes mellitus (T2DM). Metformin exhibits potential for the improvement of endothelial function and the wound healing process. However, the underlying mechanis...

journal_title：Molecular medicine reports

authors： Han X,Tao Y,Deng Y,Yu J,Sun Y,Jiang G

更新日期：2017-12-01 00:00:00

abstract：:Minoxidil and finasteride have been approved to treat hair loss by the Food and Drug Administration. However, the further elucidation of treatments for hair loss, including those using Chinese herbal medicine, remains important clinically. BeauTop (BT) is a health food supplement which contains Ginseng radix, Astragal...

journal_title：Molecular medicine reports

authors： Lee CY,Yang CY,Lin CC,Yu MC,Sheu SJ,Kuan YH

更新日期：2018-06-01 00:00:00

abstract：:Pancreatic cancer (PC) is the fourth most common cause of cancer‑related mortality worldwide and is characterized by high invasiveness and early metastasis. To identify novel diagnostic markers, the present study aimed to understand the mechanism underlying PC progression. The present study demonstrated that exosomes ...

journal_title：Molecular medicine reports

authors： Wei Q,Wei L,Zhang J,Li Z,Feng H,Ren L

更新日期：2020-10-01 00:00:00

abstract：:The purpose of this study was to assess the efficacy and predictive biomarkers of combination docetaxel-trastuzumab in a neoadjuvant setting by means of a phase II trial. Women with histologically-confirmed advanced invasive breast cancer whose tumours overexpressed HER-2 received 4 cycles of docetaxel (70 mg/m2 every...

journal_title：Molecular medicine reports

authors： Kurosumi M,Tabei T,Sano M,Honma K,Yanagita Y,Yamamoto N,Inoue K,Sato N,Kimura M

更新日期：2008-01-01 00:00:00

abstract：:The pathogenesis and therapy of hypertrophic scars (HS) have not yet been established. The aim of the present study was to investigate the potential effect of naringenin on HS and its underlying mechanisms. The mouse model of HS was prepared by a mechanical stretch device and then treated with naringenin at various co...

journal_title：Molecular medicine reports

authors： Shan S,Zhang Y,Wu M,Yi B,Wang J,Li Q

更新日期：2017-10-01 00:00:00

abstract：:It has been suggested that survivin, a member of the inhibitor of apoptosis protein (IAP) family, is an attractive novel target for anticancer therapy. The present study investigated the expression of survivin during the early stages of hepatocellular carcinoma (HCC) and associated hepatitis, and attempted to elucidat...

journal_title：Molecular medicine reports

authors： Mamori S,Matsushima M,Matsuura T,Tajiri H

更新日期：2009-11-01 00:00:00

abstract：:The β1‑adrenergic receptor (AR) is the primary β‑AR subtype in the heart and is the target of metoprolol (Met), which is commonly used to treat angina and hypertension. Previous studies have revealed a positive correlation between the methylation levels of the adrenoreceptor β1 gene (Adrb1) promoter in the myocardium ...

journal_title：Molecular medicine reports

authors： Huang Y,Liu XL,Wen J,Huang LH,Lu Y,Miao RJ,Liu X,Li Y,Xing XW,Yuan H

更新日期：2017-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer‑associated mortality in the 21st century. microRNA (miR)‑23b has been shown to be involved in the pathogenesis of many cancers, including breast and prostate cancer. However, the role of miR‑23b in HCC remains unclear. The present study revealed a neg...

journal_title：Molecular medicine reports

authors： Jiang T,Huang Z,Zhang S,Zou W,Xiang L,Wu X,Shen Y,Liu W,Zeng Z,Zhao A,Zhou S,Zeng Q

更新日期：2018-08-01 00:00:00

abstract：:The present study aimed to test whether 20-hydroxyeicosatetraenoic acid (20‑HETE) affected neddylation modification of E3‑ligase Nedd4‑2 (neural precursor cell expressed, developmentally down‑regulated 4‑like, E3 ubiquitin protein ligase). A cytochrome P450 family 4 subfamily F member 2 (CYP4F2) transgenic mouse model...

journal_title：Molecular medicine reports

authors： Zhao J,Zhang B,Lai G,Xu R,Chu G,Zhao Y

更新日期：2017-12-01 00:00:00

abstract：:ABO genotyping is commonly used in several situations, including blood transfusion, personal identification and disease detection. The present study developed a novel method for ABO genotyping, using loop‑mediated isothermal amplification (LAMP). This method allows the simultaneous determination of six ABO genotypes u...

journal_title：Molecular medicine reports

authors： Zhang C,Zhu J,Yang J,Wan Y,Ma T,Cui Y

更新日期：2015-10-01 00:00:00

abstract：:Inflammation is a potent promoter of tumor metastasis. The aim of the present study was to explore the function of systemic inflammation in the formation of lung metastasis of breast cancer cells in a mouse model. BALB/c mice were injected intraperitoneally with lipopolysaccharide (LPS) in order to establish an inflam...

journal_title：Molecular medicine reports

authors： Li S,Xu X,Jiang M,Bi Y,Xu J,Han M

更新日期：2015-06-01 00:00:00

abstract：:Hydroxyapatite scaffolds (HASs) are widely studied as suitable materials for bone replacement scaffolds due to their chemical similarities to organic materials. In our previous study, a novel HAS with a 25‑30‑µm groove structure (HAS‑G) exhibited enhanced osteogenesis of bone mesenchymal stromal cells (BMSCs) compared...

journal_title：Molecular medicine reports

authors： Li C,Yang L,Ren X,Lin M,Shen D,Li Y,Zhang X,Liu C,Mu Y

更新日期：2020-10-01 00:00:00

abstract：:CXC195 exhibits strong protective effects against neuronal apoptosis by exerting antioxidant activity. However, the pharmacological function of CXC195 in cancer remains to be elucidated. The present study demonstrated that CXC195 exhibited significant cytotoxic effects, and induced cell cycle arrest and apoptosis in H...

journal_title：Molecular medicine reports

authors： Chen XL,Fu JP,Shi J,Wan P,Cao H,Tang ZM

更新日期：2015-12-01 00:00:00

abstract：:We investigated the effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-β1 protein expression in rat endplate chondrocytes in vitro. Endplate chondrocytes were isolated and cultured in vitro. Following identific...

journal_title：Molecular medicine reports

authors： Xu HG,Hu CJ,Wang H,Liu P,Yang XM,Zhang Y,Wang LT

更新日期：2011-09-01 00:00:00

abstract：:The p38 pathway, which is important in mitogen-activated protein kinase (MAPK) family protein signaling, leads to mitochondrial dysfunction and activation of caspase-3. B-cell lymphoma 2 (Bcl‑2) family members are involved in the regulation of activities associated with the survival and death of neurons through apopto...

journal_title：Molecular medicine reports

authors： Liu XW,Ji EF,He P,Xing RX,Tian BX,Li XD

更新日期：2014-10-01 00:00:00

abstract：:Lung cancer is the most common cancer worldwide, and morbidity and mortality associated with lung cancer has been increasing annually in recent decades. MicroRNAs (miRNAs), which are short non‑coding RNA sequences that are involved in the regulation of gene expression, have been previously demonstrated to be key regul...

journal_title：Molecular medicine reports

authors： Li J,Jin H,Yu H,Wang B,Tang J

更新日期：2017-09-01 00:00:00

abstract：:Gemcitabine is a first‑line chemotherapeutic agent used in the treatment of pancreatic cancer; however resistance of the disease to the drug often develops over time. Agents that can either enhance the effects of gemcitabine, or help to overcome the chemoresistance to the drug are needed for the successful treatment o...

journal_title：Molecular medicine reports

authors： Liu DL,Bu HQ,Jin HM,Zhao JF,Li Y,Huang H

更新日期：2014-12-01 00:00:00