Abstract:
STUDY DESIGN:In vitro and in vivo study. OBJECTIVE:To evaluate the role of recombinant human bone morphogenetic protein-2 (rhBMP2) on breast cancer cell (MDA-MB-231 cells) growth. SUMMARY OF BACKGROUND DATA:Bone morphogenetic proteins (BMPs) are expressed in a variety of human carcinoma cell lines and are known to promote tumor invasion and metastasis. However, their roles in tumor progression have not been fully clarified. In addition, there is no in vivo study regarding the inhibitory effect of BMP2 on breast cancer cell proliferation. METHOD:Cell proliferation was determined by BrdU incorporation assay and flow cytometry. BMP2 signal transduction pathways were estimated on Western blot. Fifteen animals were divided into 2 groups; 1 (control = 5) was breast cancer cells alone, while the other (experiment = 5) was rhBMP2 + breast cancer cells. Cancer cells were injected into 2 sites (subcutaneous and femur) of nude mice with or without BMP2. Tumor size was determined by direct measurements for subcutaneous tumor formation and by femur radiographs. Histological and immunohistochemical analyses were performed. RESULTS:RhBMP2 inhibited the proliferation of MDA-MB-231 cells in vitro. Inhibition was associated with changes in both the Smad and Wnt signaling pathways and was ultimately mediated through effects on various cell cycle proteins. Furthermore, rhBMP2 inhibited the growth of MDA-MB-231 cells injected both subcutaneously and intrafemorally. CONCLUSION:In this model using human breast adenocarcinoma cell line, rhBMP2 has no stimulatory effect of tumor growth. Therefore, we can provide the basic science data to support the utilization in the management of patients with spine tumor in the future.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Ye S,Park BH,Song KJ,Kim JR,Jang KY,Park HS,Bae JS,Brochmann EJ,Wang JC,Murray SS,Lee KBdoi
10.1097/BRS.0b013e31827db4c6subject
Has Abstractpub_date
2013-02-01 00:00:00pages
E143-50issue
3eissn
0362-2436issn
1528-1159journal_volume
38pub_type
杂志文章相关文献
SPINE文献大全abstract::Segmental spinal instability was evaluated with magnetic resonance (MR) imaging, computed tomography (CT), and conventional radiography in 33 patients who had undergone surgical spinal fusion. In 16 of the 19 patients who had a diagnosis of solid fusion, the immobilized vertebral bodies demonstrated areas of high sign...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199006000-00028
更新日期:1990-06-01 00:00:00
abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:To report results at a minimum 5 years after pedicle subtraction osteotomy for fixed sagittal imbalance. SUMMARY OF BACKGROUND DATA:No one has reported results of pedicle subtraction osteotomies with a 5- to 8-year follow-up. METHOD:Thirty-five consecutive patients with sa...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31814b8371
更新日期:2007-09-15 00:00:00
abstract:STUDY DESIGN:Repeated cross-sectional analysis using national Medicare data from the Dartmouth Atlas Project. OBJECTIVE:To describe recent trends and geographic variation in population-based rates of lumbar fusion spine surgery. SUMMARY OF BACKGROUND DATA:Lumbar fusion rates have increased dramatically during the 198...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000248132.15231.fe
更新日期:2006-11-01 00:00:00
abstract:STUDY DESIGN:Survey. OBJECTIVE:The purpose of this research was to help determine whether sedation is indicated before lumbar and cervical interventional pain management procedures, and additionally, to determine whether benzodiazepams are effective at controlling anxiety for these procedures. SUMMARY OF BACKGROUND D...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/BRS.0b013e31815b7e9f
更新日期:2007-12-01 00:00:00
abstract:STUDY DESIGN:The authors developed a rat-tail model to investigate the hypothesis that vertebral wedging during growth in progressive spinal deformities results from asymmetric loading in a "vicious cycle." OBJECTIVES:To document growth curves with axial compression or distraction applied to tail vertebrae to determin...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199605150-00007
更新日期:1996-05-15 00:00:00
abstract::Lumbar intervertebral joints were subjected to compressive and shear forces calculated to simulate walking with a heavy pack on the back. The joints with articular tropism were found to rotate toward the side of the more oblique facet. The mechanics relating the orientation of the articular facets with joint forces an...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198003000-00011
更新日期:1980-03-01 00:00:00
abstract::To study possible neurologic complications, five lambs were operated on by sublaminar wiring at the thoracolumbar spine. Monitoring of the central motor pathway was carried out by percutaneous electrostimulation. A comparative anatomic study was designed to compare the magnitude of the spinal canal and the area occupi...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199204000-00011
更新日期:1992-04-01 00:00:00
abstract:STUDY DESIGN:Case report. OBJECTIVE:We report a case of a 16-year-old boy with intermittent and migratory polyarthralgia, who made a diagnostic dilemma. SUMMARY OF BACKGROUND DATA:Spinal involvement without spinal symptom in gout seems to be rare. However, the relationship of spinal gout to symptoms is poorly underst...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002403
更新日期:2018-04-15 00:00:00
abstract:STUDY DESIGN:A prospective cohort study. OBJECTIVE:To evaluate the effects of epidural steroid injections (ESIs) on blood glucose levels in patients with diabetes mellitus. SUMMARY OF BACKGROUND DATA:ESIs are commonly used in the treatment of multiple spinal disorders. Corticosteroid injections have been evaluated in...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/BRS.0b013e31821fd21f
更新日期:2012-01-01 00:00:00
abstract:STUDY DESIGN:An analysis of computed tomography images of patients with adolescent idiopathic scoliosis. OBJECTIVES:To evaluate the spatial relations between the vertebral body and the thoracic aorta and to verify the safety of anterior instrumentation surgery. SUMMARY OF BACKGROUND DATA:Recent studies have suggested...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000138409.14577.f0
更新日期:2004-09-15 00:00:00
abstract:STUDY DESIGN:Retrospective case series. OBJECTIVE:Our goal was to assess whether en bloc resection had an impact on survival. SUMMARY OF BACKGROUND DATA:Osteogenic sarcoma occurs rarely in the mobile spine, but when it does, the prognosis is poor. Wide resection is recommended for osteogenic sarcoma of the extremitie...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31822fb1a7
更新日期:2012-03-15 00:00:00
abstract:STUDY DESIGN:The authors have developed technique of using anterior neck derivations to record posterior tibial nerve N28 during operative somatosensory-evoked potential monitoring. OBJECTIVE:This prospective study of 10 patients compared the ease of application of electrodes and stability of waveforms with "tradition...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199504000-00008
更新日期:1995-04-01 00:00:00
abstract:STUDY DESIGN:Case report and biomechanical study. OBJECTIVE:The objectives of this study were to report on a single case of a failed nucleus replacement device and to test the biomechanical properties of the failed device. SUMMARY OF BACKGROUND DATA:The use of spine arthroplasty techniques in the treatment of degener...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181dfbc78
更新日期:2010-10-15 00:00:00
abstract:STUDY DESIGN:Cross-seccional analysis. OBJECTIVE:To define the clinical usefulness of vestibular-evoked myogenic potential (VEMP) in detecting cervical medullar involvement related to human T-cell lymphotropic virus type 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP). SUMMARY OF BACKGROUND DA...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31817152ed
更新日期:2008-05-15 00:00:00
abstract:STUDY DESIGN:This was a population-based retrospective study. OBJECTIVE:To fully estimate the costs of the Hong Kong scoliosis screening program through a large, population-based study. SUMMARY OF BACKGROUND DATA:School screening for scoliosis has often been criticized for having high costs. In fact, the screening co...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181cbcc10
更新日期:2010-12-15 00:00:00
abstract:STUDY DESIGN:Diagnosis, postoperative complications, and surgical results in patients over 70 years old who underwent surgery for lumbar nerve root compression of a degenerative origin were evaluated in a prospective, consecutive study. SUMMARY OF BACKGROUND DATA:Of the 50 patients investigated, 43 suffered from centr...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199407000-00001
更新日期:1994-07-01 00:00:00
abstract:STUDY DESIGN:Retrospective single center analysis. OBJECTIVE:The purpose of our study is to quantify the development of a postoperative radiculitis in our minimally invasive transforaminal lumbar interbody fusion patient population. SUMMARY OF BACKGROUND DATA:The application of recombinant human Bone Morphogenetic Pr...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181a396a1
更新日期:2009-06-15 00:00:00
abstract:STUDY DESIGN:Retrospective. OBJECTIVE:With approximately 10,000 new spinal cord injury (SCI) patients in the United States each year, predicting public health outcomes is an important public health concern. Combining all regions of the spine in SCI trials may be misleading if the lumbar and sacral regions (conus) have...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181fd6b36
更新日期:2011-01-01 00:00:00
abstract:STUDY DESIGN:A case of cauda equina syndrome is reported. OBJECTIVE:To recognize a serious complication related to the use of Gelfoam in the lumbar spine. SUMMARY AND BACKGROUND DATA:Absorbable hemostatic gelatin sponges have long been used to control bleeding around the spinal cord. Despite widespread use and a safe...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200110150-00029
更新日期:2001-10-15 00:00:00
abstract:STUDY DESIGN:In vivo measurements of low back flexion posture and muscle activity before, during, and after static flexion. OBJECTIVE:To identify the occurrence of creep and muscle fatigue development in the low back during static upper body deep flexion that resembled an above ground work posture. SUMMARY OF BACKGRO...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181aa6a55
更新日期:2009-08-01 00:00:00
abstract:STUDY DESIGN:Cross-sectional study. OBJECTIVE:To compare quality of life and caregiver burden in traditional growing rod (TGR) and magnetic controlled growing rods (MCGR) patients. SUMMARY OF BACKGROUND DATA:MCGR decrease surgical sessions associated with treatment of early onset scoliosis (EOS), hoping to minimize t...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002274
更新日期:2018-01-15 00:00:00
abstract:STUDY DESIGN:Prospective trial. OBJECTIVE:To perform a precise anatomical study of the presacral space and to examine the approach safety of AxiaLIF (axial lumbar interbody fusion) in an anatomical aspect. SUMMARY OF BACKGROUND DATA:AxiaLIF is a novel, minimally invasive surgery. Though there were a few clinical repo...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31821b8f6d
更新日期:2012-02-15 00:00:00
abstract:STUDY DESIGN:Validity and responsiveness study using a randomized clinical trial and prospective cohort study of patients with low back pain (LBP). OBJECTIVE:To provide evidence for construct validity and responsiveness to change of a single-item presenteeism question (SIPQ) in patients with LBP. SUMMARY OF BACKGROUN...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000162
更新日期:2014-03-01 00:00:00
abstract:STUDY DESIGN:Retro-prospective study. OBJECTIVES:To identify the incidence and the risk factors associated with the development of Facial pressure ulcers (FPU) in patients underwent spine surgery in prone position for at least 3 hours. SUMMARY OF BACKGROUND DATA:FPU is a serious complication that can occur after prol...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003892
更新日期:2020-12-17 00:00:00
abstract:STUDY DESIGN:Systematic review. OBJECTIVE:To determine the effectiveness and safety of cervical laminoplasty versus laminectomy and fusion for the treatment of cervical myelopathy, and to identify any patient subgroups for whom one treatment may result in better outcomes than the other. SUMMARY OF BACKGROUND DATA:Cer...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0b013e3182a7eb7c
更新日期:2013-10-15 00:00:00
abstract:STUDY DESIGN:A multiple-comparative study between normal and low back pain (LBP) patients before and after rehabilitation. OBJECTIVE:To examine whether there is a change in flexion-relaxation phenomenon in sitting in LBP patient following a rehabilitation treatment. SUMMARY OF BACKGROUND DATA:There is an association ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181ba021e
更新日期:2010-07-15 00:00:00
abstract::During magnetic resonance imaging, a vast amount of digital data on anatomic structures is translated into images, which are then assessed subjectively. The development of an objective, sensitive method to directly assess the digital data would have clear benefits, particularly for clinical research on disc degenerati...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199401001-00014
更新日期:1994-01-15 00:00:00
abstract:STUDY DESIGN:Retrospective multicenter database review. OBJECTIVE:The aim of this study was to evaluate national postoperative outcomes and hospital characteristics trends from 2001 to 2010 for advanced age CSM patients. SUMMARY OF BACKGROUND DATA:Recent studies show increases in US cervical spine surgeries and CSM d...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0000000000001181
更新日期:2016-02-01 00:00:00
abstract:STUDY DESIGN:A structured literature review. SUMMARY OF THE BACKGROUND DATA:Widely recognized classification criteria for rheumatologic disorders have resulted in well-defined patient populations for clinical investigation. OBJECTIVE:We sought to determine whether similar criteria were needed for back pain disorders ...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0b013e3181bc9454
更新日期:2010-04-01 00:00:00
abstract:STUDY DESIGN:This is a single-center retrospective case-control study of 7 transfusion-related acute lung injury (TRALI) cases and 28 controls in the pediatric spinal surgery population. OBJECTIVE:To determine the association between maternal transfusion and risk of TRALI in pediatric spinal surgery patients. SUMMARY...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181e3dad2
更新日期:2010-11-01 00:00:00