Abstract:
:In the present study, we investigated the anti-inflammatory effects of a nutritious vegetable Toona sinensis (leaf extracts, TS) and its major bioactive compound gallic acid (GA) by analysing LPS-induced NF-κB activation in transgenic mice, using bioluminescence imaging. Mice were challenged intraperitoneally with LPS (1mg/kg) and treated orally with TS or GA (100 or 5mg/kg, respectively). In vivo and ex vivo imaging showed that LPS increased NF-κB luminescence in the abdominal region, which was significantly inhibited by TS or GA. Immunohistochemical and ELISA analyses confirmed that TS and GA inhibited LPS-induced NF-κB, interleukin-1β, and tumour necrosis factor-α expression. Microarray analysis revealed that biological pathways associated with metabolism and the immune responses were affected by TS or GA. Particularly, LPS-induced thioredoxin-like 4B (TXNL4B) 2 expression in the small intestine, and TXNL4B, iNOS, and COX-2 expression in RAW 264.7 cells were significantly inhibited by TS or GA. Thus, the anti-inflammatory potential of TS was mediated by the downregulation of NF-κB pathway.
journal_name
Food Chemjournal_title
Food chemistryauthors
Hsiang CY,Hseu YC,Chang YC,Kumar KJ,Ho TY,Yang HLdoi
10.1016/j.foodchem.2012.08.009subject
Has Abstractpub_date
2013-01-15 00:00:00pages
426-34issue
2eissn
0308-8146issn
1873-7072pii
S0308-8146(12)01292-7journal_volume
136pub_type
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