Abstract:
:Acquired α-thalassemia (α-thal) myelodysplastic syndrome (ATMDS) is a rare acquired syndrome characterized by a somatic point mutation in the ATRX gene in patients with chronic myeloid disorders. We describe the case of a 78-year-old man with myelodysplastic syndrome (MDS) and striking microcytic, hypochromic anemia. Brilliant cresyl blue supravital stain of the peripheral blood and hemoglobin (Hb) electrophoresis showed the presence of Hb H. Sequence analysis of unfractionated peripheral blood DNA identified a G>T transition at codon 524 in exon 7 of the ATRX gene. To the best of our knowledge, it is the first description of this point mutation of the ATRX gene in an ATMDS.
journal_name
Hemoglobinjournal_title
Hemoglobinauthors
Herbaux C,Badens C,Guidez S,Lacoste C,Maboudou P,Rose Cdoi
10.3109/03630269.2012.724040subject
Has Abstractpub_date
2012-01-01 00:00:00pages
581-5issue
6eissn
0363-0269issn
1532-432Xjournal_volume
36pub_type
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