Clinical, histologic, and genetic features of mesothelioma in a 7-year-old child.

Abstract:

:Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was diagnosed with MM based on histology, extensive immunohistochemical analyses, and an elevated serum CA-125 level. Cytogenetics and comparative genomic hybridization (CGH) analysis of his tumor identified a single extra copy number of chromosome 11 with few other changes noted.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Sugalski A,Davis M,Prasannan L,Saldivar V,Hung JY,Tomlinson GE

doi

10.1002/pbc.24284

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

146-8

issue

1

eissn

1545-5009

issn

1545-5017

journal_volume

60

pub_type

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