Abstract:
:Genome-wide association studies and integrative genomics approaches have demonstrated significant associations between chronic obstructive pulmonary disease (COPD) and single-nucleotide polymorphisms (SNPs) in the chromosome 15q25 region that includes iron-responsive element binding protein 2 gene (IREB2) and CHRNA3/5 in non-Asian populations. We investigated whether IREB2 and CHRNA3/5 polymorphisms would be associated with COPD susceptibility and COPD-related phenotypes in a Chinese Han population. Eight SNPs (rs2568494, rs2656069, rs10851906, rs1964678, rs12593229, rs965604, rs13180, rs17483929) in IREB2 gene and four SNPs (rs16969968, rs1051730, rs938682, rs8034191) in or near CHRNA3/5 locus were genotyped in a case-control study (680 COPD patients and 687 controls). No significant associations were found between any of the SNPs and COPD in either former-smokers or current-smokers. Two SNPs (rs2656069 and rs10851906) in IREB2 were associated with COPD (P=0.045 and 0.032, respectively) in non-smoker. Four SNPs (rs1964678, rs12593229, rs965604 and rs13180) in IREB2 were associated with forced expiratory volume in 1 s (FEV(1))% predicted and three SNPs (rs16969968, rs8034191 and rs1051730) in CHRNA3/5 were both associated with FEV(1)% predicted and FEV(1)/FVC in COPD cases (P range 0.007-0.050). The SNP rs8034191 near CHRNA3/5 locus was significantly associated with pack-years of smoking in COPD patients (P=0.033). We demonstrated IREB2 polymorphisms were associated with COPD in non-smoking subjects, and the effect of IREB2 gene on COPD may be independent from smoking and independent from CHRNA3/5 gene cluster. Besides, we confirmed that SNPs in these two gene loci were associated with pulmonary function and CHRNA3/5 polymorphism was associated with pack-year of smoking in COPD patients in the Chinese Han population.
journal_name
J Hum Genetjournal_title
Journal of human geneticsauthors
Zhou H,Yang J,Li D,Xiao J,Wang B,Wang L,Ma C,Xu S,Ou X,Feng Ydoi
10.1038/jhg.2012.104subject
Has Abstractpub_date
2012-11-26 00:00:00pages
738-46issue
11eissn
1434-5161issn
1435-232Xpii
jhg2012104journal_volume
57pub_type
杂志文章abstract::In successive reports from 2014 to 2015, X-ray repair cross-complementing protein 4 (XRCC4) has been identified as a novel causative gene of primordial dwarfism. XRCC4 is indispensable for non-homologous end joining (NHEJ), the major pathway for repairing DNA double-strand breaks. As NHEJ is essential for V(D)J recomb...
journal_title:Journal of human genetics
pub_type: 杂志文章,评审
doi:10.1038/jhg.2016.46
更新日期:2016-08-01 00:00:00
abstract::Interstitial deletion of 7q11.23-q21.11 was identified by cytogenetic methods in a 4-year-old boy with Williams syndrome (WS) and infantile spasms. Deletion of the elastin (ELN) gene and the DNA polymorphic markers, D7S1870, D7S2490, D7S2518, and D7S2421, were identified in the patient, but the loci for D7S653 and D7S...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s100380050064
更新日期:1998-01-01 00:00:00
abstract::We analyzed the mitochondrial DNA extracted from 14 human skeletal remains from the Doigahama site in Japan to clarify the genetic structure of the Doigahama Yayoi population and the relationship between burial style and kinship among individuals. The sequence types obtained in this study were compared with those of t...
journal_title:Journal of human genetics
pub_type: 历史文章,杂志文章
doi:10.1038/jhg.2009.81
更新日期:2009-10-01 00:00:00
abstract::In mammals, X-linked gene products can be dosage compensated between males and females by inactivation of one of the two X chromosomes in the developing female embryos. X inactivation choice is usually random in embryo mammals, but several mechanisms can influence the choice determining skewed X inactivation. As a con...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s10038-006-0049-6
更新日期:2006-01-01 00:00:00
abstract::Fucosidosis is a rare lysosomal storage disease caused by a defect of the alpha-L: -fucosidase (FUCA1) gene. Worldwide 26 mutations underlying the disease have been reported. By direct DNA sequencing of exons and flanking introns, homozygous Y126X mutation and Q281R polymorphism were found in a Taiwanese patient with ...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s10038-007-0136-3
更新日期:2007-01-01 00:00:00
abstract::It is well known that individuals with low, or lack of, antibody production in response to hepatitis B surface antigen (HBsAg) exist in the human population. We have previously reported that HLA class I and class II genes are both involved in antibody production to HBsAg, and that specific alleles of HLA are associate...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s100380170089
更新日期:2001-01-01 00:00:00
abstract::Recently, the use of genome-wide linkage disequilibrium (LD) analysis to localize traits has attracted much attention because of the introduction of high-throughput genotyping systems. However, a limitation of such studies is often the total cost of genotyping in addition to sample size. Therefore, it is important to ...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s100380200050
更新日期:2002-01-01 00:00:00
abstract::Intellectual disability (ID) accounts for 1% of the general population, and it is caused by the interplay between the genetic and/or environmental factors. The genetic components responsible for the development of ID are highly heterogeneous, and the phenotype and severity of the disease vary in patients even if they ...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/s10038-020-0809-8
更新日期:2020-10-09 00:00:00
abstract::The differential transmission of alleles from parents to affected children indicates that the locus under investigation is either directly involved in the occurrence of the disease or that there are allelic associations with other loci that are directly involved. Conditional logistic regression applied to a diallelic ...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s10038-004-0217-5
更新日期:2005-01-01 00:00:00
abstract::As the mouse nasal embryonic LHRH factor gene (Nelf) encodes a guidance molecule for the migration of the olfactory axon and gonadotropin-releasing hormone neurons, its human homolog, NELF, is a candidate gene for Kallmann syndrome, a disease of idiopathic hypogonadotropic hypogonadism (IHH) with anosmia or hyposmia. ...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s10038-004-0137-4
更新日期:2004-01-01 00:00:00
abstract::The use of mixed models to determine narrow-sense heritability and related quantities such as SNP heritability has received much recent attention. Less attention has been paid to the inherent variability in these estimates. One approach for quantifying variability in estimates of heritability is a frequentist approach...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/jhg.2014.15
更新日期:2014-05-01 00:00:00
abstract::Many consortia and international projects have investigated the human genetic variation of a large number of ethno-geographic groups. However, populations with peculiar genetic features, such as the Turkish population, are still absent in publically available datasets. To explore the genetic predisposition to health-r...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/jhg.2015.8
更新日期:2015-04-01 00:00:00
abstract::X-linked inheritance is very rare and is estimated to account for only 1-5% of all nonsyndromic hearing loss cases. We found a multiplex family from China segregating with X-linked nonsyndromic hearing loss. After exclusive analysis of 10 common variations of three hearing loss-related genes, GJB2, mtDNA12srRNA and SL...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/s10038-018-0443-x
更新日期:2018-06-01 00:00:00
abstract::Two novel mutations in the gene encoding T-protein, a component of the glycine cleavage system, were identified in a Japanese family with nonketotic hyperglycinemia. The proband had two affected sibs, and enzymatic analysis of the liver sample from the proband revealed the T-protein deficiency. The first mutation, 183...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s100380050055
更新日期:1998-01-01 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease that is refractory to treatment and carries a high mortality rate. IPF is frequently associated with lung cancer. Identification of molecular targets involved in both diseases may elucidate novel molecular mechanisms contributing to their patho...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/jhg.2016.99
更新日期:2016-12-01 00:00:00
abstract::Dyslipidemia and insulin resistance contribute to the endothelial cell dysfunction in hypertensive disorders of pregnancy (HDP) and increase the long-term risk of cardiovascular disease (CVD). The genes linking susceptibility to gestational hypertension (GH) and/or preeclampsia (PE) to the long-term risk of CVD are st...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s10038-006-0106-1
更新日期:2007-01-01 00:00:00
abstract::The name Fon-Jou Hsieh was inadvertently omitted from the list of authors. The name should be added as the third author of the article. ...
journal_title:Journal of human genetics
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10038-006-0367-8
更新日期:2006-03-01 00:00:00
abstract::We report the clinical and biochemical findings from a patient who presented with Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS), an autosomal-dominant disorder characterized by optic atrophy, developmental delay and intellectual disability. In addition, the patient also displays hypotonia, stroke-like episodes...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/s10038-017-0398-3
更新日期:2018-04-01 00:00:00
abstract::GATA zinc finger domain-containing 2B (GATAD2B) is a subunit of the methyl-CpG-binding protein-1 complex (MECP1), which deacetylates methylated nucleosomes and regresses transcriptional activity. Recently, GATAD2B has been elucidated as a candidate gene in patients with intellectual disability (ID). In this study, we ...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/jhg.2016.164
更新日期:2017-04-01 00:00:00
abstract::Genetic and lifestyle factors are important in the pathogenesis of osteoporosis. We investigated the relationships of PvuII and XbaI polymorphisms of the estrogen receptor alpha (ER-alpha) gene, lifestyle factors with speed of sound at the calcaneus (calcaneal SOS) and osteoporosis in a population-based study of 140 h...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s10038-006-0055-8
更新日期:2006-01-01 00:00:00
abstract::Local genomic architecture, such as segmental duplications (SDs), can induce copy number variations (CNVs) hotspots in the human genome, many of which manifest as genomic disorders. Significant technological advances have been achieved for genome-wide CNV investigations, but these costly methods are not suitable for g...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/jhg.2012.66
更新日期:2012-08-01 00:00:00
abstract::Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1, also known as PC-1) inhibits insulin signal transduction pathway(s). Previous studies have demonstrated the K121Q variant of the ENPP1 gene to have a significant functional role in determining susceptibility to insulin resistance and type 2 diabetes (T2D). To...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s10038-006-0399-0
更新日期:2006-01-01 00:00:00
abstract::To conduct a long-term birth cohort study that includes genetic analysis, it is crucial to understand the attitudes of participants to genetic analysis and then take appropriate approaches for addressing their ambiguous and negative attitudes. This study aimed to explore participants' attitudes toward genetic analysis...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/s10038-020-00894-7
更新日期:2021-01-25 00:00:00
abstract::Approximately one-third of the mammalian genome is composed of highly repeated DNA sequences, of which the two major families, the long and short inter-spersed nucleotide elements (LINEs and SINEs), are represented in humans by L1 and Alu elements respectively. Both 'types of element are considered to be retrotranspos...
journal_title:Journal of human genetics
pub_type: 杂志文章,评审
doi:10.1007/s100380050045
更新日期:1998-01-01 00:00:00
abstract::Genetic studies of neuropsychiatric disorders have often produced conflicting results, which might partly result from the involvement of epigenetic modifications. We intended to explore the possible implication of DNA methylation and human endogenous retroviruses (HERVs) in neuropsychiatric disorders. In the present s...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s10038-003-0081-8
更新日期:2003-01-01 00:00:00
abstract::Hereditary motor and sensory neuropathy with proximal dominancy (HMSN-P) is an adult-onset peripheral neurodegenerative disorder which has been reported only in the Okinawa Islands, Japan. The disease locus of "Okinawa-type" HMSN-P has been previously mapped to 3q13.1, with all affected individuals sharing an identica...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1007/s10038-007-0193-7
更新日期:2007-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are endogenous non-coding RNAs that function as negative regulators of gene expression. Alterations in miRNA expression have been shown to affect tumor growth and response to chemotherapy. In this study, we explored the possible role of miRNAs in cisplatin resistance in esophageal squamous cell carc...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/jhg.2011.1
更新日期:2011-04-01 00:00:00
abstract::Leptin, a possible mediator between energy homeostasis, inflammation and cardiovascular disease (CVD), acts via leptin receptors. We investigated association of single-nucleotide polymorphisms (SNPs) and haplotypes of the leptin receptor gene (LEPR) with several CVD risk factors: body mass index, waist circumference (...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/jhg.2014.82
更新日期:2014-11-01 00:00:00
abstract::Schizophrenia is a highly complex inheritable disease characterized by numerous genetic susceptibility elements, each contributing a modest increase in risk for the disease. Although numerous linkage or association studies have identified a large set of schizophrenia-associated loci, many are controversial. In additio...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/jhg.2010.24
更新日期:2010-05-01 00:00:00
abstract::Trisomy 18 (T18) and trisomy 13 (T13) are major concerns in prenatal genetic testing due to their poor prognosis; very low birth weight (VLBW) is also a concern in neonatology. The aim of this study was to investigate the mortality and morbidity of VLBW infants diagnosed with T18/T13 in Japan, compared with those with...
journal_title:Journal of human genetics
pub_type: 杂志文章
doi:10.1038/s10038-020-00825-6
更新日期:2021-03-01 00:00:00