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Genetic diversity of disease-associated loci in Turkish population.

Abstract：

:Many consortia and international projects have investigated the human genetic variation of a large number of ethno-geographic groups. However, populations with peculiar genetic features, such as the Turkish population, are still absent in publically available datasets. To explore the genetic predisposition to health-related traits of the Turkish population, we analyzed 34 genes associated with different health-related traits (for example, lipid metabolism, cardio-vascular diseases, hormone metabolism, cellular detoxification, aging and energy metabolism). We observed relevant differences between the Turkish population and populations with non-European ancestries (that is, Africa and East Asia) in some of the investigated genes (that is, AGT, APOE, CYP1B1, GNB3, IL10, IL6, LIPC and PON1). As most complex traits are highly polygenic, we developed polygenic scores associated with different health-related traits to explore the genetic diversity of the Turkish population with respect to other human groups. This approach showed significant differences between the Turkish population and populations with non-European ancestries, as well as between Turkish and Northern European individuals. This last finding is in agreement with the genetic structure of European and Middle East populations, and may also agree with epidemiological evidences about the health disparities of Turkish communities in Northern European countries.

journal_name

J Hum Genet

journal_title

Journal of human genetics

authors

Karaca S,Cesuroglu T,Karaca M,Erge S,Polimanti R

doi

10.1038/jhg.2015.8

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

193-8

issue

4

eissn

1434-5161

issn

1435-232X

pii

jhg20158

journal_volume

60

pub_type

杂志文章

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