Abstract：
BACKGROUND:In opioid dependent youth there is substantial attrition from medication-assisted treatment. If youth at risk for attrition can be identified at treatment entry or early in treatment, they can be targeted for interventions to help retain them in treatment. METHODS:Opioid dependent adolescents and young adults (n=152), aged 15-21, were randomized to 12 weeks (BUP, n=74) or 2 weeks of detoxification (DETOX, n=78) with buprenorphine/naloxone (Bup/Nal), both in combination with 12 weeks of psychosocial treatment. Baseline and early treatment related predictors of treatment attrition were identified in each group using bivariate and multivariate logistic regression. RESULTS:In the DETOX group 36% left between weeks 2 and 4, at the end of the dose taper, while in the BUP group only 8% left by week 4. In the BUP group, early adherence to Bup/Nal, early opioid negative urines, use of any medications in the month prior to treatment entry, and lifetime non-heroin opioid use were associated with retention while prior 30-day hallucinogen use was associated with attrition. In the DETOX group, only use of sleep medications was associated with retention although not an independent predictor. A broad range of other pre-treatment characteristics was unrelated to attrition. CONCLUSIONS:Prompt attention to those with early non-adherence to medication or an early opioid positive urine, markers available in the first 2 weeks of treatment, may improve treatment retention. Extended Bup/Nal treatment appeared effective in improving treatment retention for youth with opioid dependence across a wide range of demographics, and pre-treatment clinical characteristics.
journal_name
Addict Behavjournal_title
Addictive behaviorsauthors
Warden D,Subramaniam GA,Carmody T,Woody GE,Minhajuddin A,Poole SA,Potter J,Fishman M,Bogenschutz M,Patkar A,Trivedi MHdoi
10.1016/j.addbeh.2012.04.011subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1046-53issue
9eissn
0306-4603issn
1873-6327pii
S0306-4603(12)00159-1journal_volume
37pub_type
杂志文章,随机对照试验abstract：OBJECTIVE:To examine the association between onset of substance use and risk factors related to suicide. METHOD:1252 adolescents in two urban school districts completed surveys as part of a large, randomized controlled prevention effectiveness trial. Risk factors measured included depressive symptoms, suicide ideation...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2006.11.017
更新日期：2007-08-01 00:00:00
abstract：:Retrospective studies of military personnel and survivors of community disasters suggest a link between traumatic exposure and substance use. This is the first study to investigate this association prospectively in a military population. A representative cohort of members of the UK Armed Forces was recruited into a lo...
journal_title：Addictive behaviors
pub_type： 杂志文章
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更新日期：2008-08-01 00:00:00
abstract：:Incarcerated adolescents' attributions for drug use were investigated. A new 50-item questionnaire, the Inventory of Drug Taking Situations (IDTS), was used to assess reasons for use. The IDTS yields eight subscales corresponding to risky situations identified by Marlatt and others. On the IDTS, subjects indicate how ...
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abstract：OBJECTIVE:Specific events (e.g., Spring Break, holidays) are associated with greater college student drinking. However, the ways in which specific events are celebrated at specific campuses may impact students' beliefs about the social acceptability of drinking during these events, which may impact students' event-spec...
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abstract：AIM:We examined whether reciprocal relationships were present between the SURPS personality profiles and substance use in early adolescence. METHODS:Longitudinal data of four-waves of a broader effectiveness study were used from 1068 early adolescents. RESULTS:Our cross-lagged models indicated that sensation seeking ...
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journal_title：Addictive behaviors
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abstract：:While depression, anxiety, and negative affect are associated with smoking and smoking cessation outcomes in healthy individuals, these associations have not been established in smokers with chronic diseases such as diabetes mellitus, a condition which greatly increases cardiovascular disease risk. Other psychosocial ...
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journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验,评审
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更新日期：1995-01-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/s0306-4603(00)00116-7
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journal_title：Addictive behaviors
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更新日期：2015-12-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
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doi：10.1016/j.addbeh.2013.08.034
更新日期：2014-01-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(84)90057-1
更新日期：1984-01-01 00:00:00
abstract：:The role of the endocannabinoid system in nicotine addiction is being increasingly acknowledged. We conducted a pilot, randomised double blind placebo controlled study set out to assess the impact of the ad-hoc use of cannabidiol (CBD) in smokers who wished to stop smoking. 24 smokers were randomised to receive an inh...
journal_title：Addictive behaviors
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.addbeh.2013.03.011
更新日期：2013-09-01 00:00:00
abstract：:This study aimed to investigate factors related to initiation of cannabis consumption among adolescents. A questionnaire was administered to 2043 14-15-year-olds from Barcelona who were followed-up and re-interviewed after 15 months. A bivariate analysis was performed to identify the factors associated with consumptio...
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title：Addictive behaviors
pub_type： 杂志文章
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更新日期：2004-05-01 00:00:00
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