Abstract:
:In this study, the effect of heparin-derived oligosaccharide on bovine vascular smooth muscle cell (VSMC) proliferation and signal transduction mechanism was investigated. Extracellular-signal-regulated kinase (ERK) 1/2 has been implicated in the regulation of various cellular functions including proliferation, and we sought to define a functional role for ERK 1/2 in an established proliferation model in order to find a possible mechanism for inhibition of VSMC proliferation by heparin-derived oligosaccharide. The VSMC proliferation model was developed by platelet-derived growth factor (PDGF), and the level of ERK 1/2 protein and messenger RNA was determined by reverse transcriptase-polymerase chain reaction, Western blotting, and immunocytochemical methods. Flow cytometry analysis indicated that heparin-derived oligosaccharide blocked PDGF-induced cell cycle progression by arresting cells in the G0/G1 phase. The results imply that heparin-derived oligosaccharide inhibits VSMC proliferation by moderating the gene and the phosphorylation levels of ERK 1/2, eventually blocking G1/S transition, may be one of the mechanisms for inhibition of VSMC proliferation by heparin-derived oligosaccharide.
journal_name
Vasc Endovascular Surgjournal_title
Vascular and endovascular surgeryauthors
Li L,Li W,Ren Z,He S,Xu G,Yang Ldoi
10.1177/1538574412442595subject
Has Abstractpub_date
2012-07-01 00:00:00pages
393-400issue
5eissn
1538-5744issn
1938-9116pii
1538574412442595journal_volume
46pub_type
杂志文章abstract:BACKGROUND:Many devices are available for endovascular aneurysm repair (EVAR). Our aim was to analyze morphological effects of the Zenith and Talent systems. METHODS:Patients included underwent EVAR from June 1999 to June 2005 using a Zenith or Talent stent-graft, with computed tomography follow-up. Aortic dimensions ...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574407307404
更新日期:2007-12-01 00:00:00
abstract::Patients with chronic occlusion of iliac veins may present with symptoms ranging from mild discomfort to severe disability, including limb swelling, venous claudication, and ulceration. Endovascular treatment has emerged as first line of interventional therapy. Surgical venous-venous bypasses for the management of the...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574412454584
更新日期:2012-10-01 00:00:00
abstract::Abnormal aortic arch anatomy is relatively uncommon but most frequently involves an aberrant right subclavian artery. Rarely, it is associated with aneurysmal dilatation of a chronic type B dissection. Under such circumstances, the abnormal anatomy may complicate therapeutics options. Furthermore, controversy exists r...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574408328662
更新日期:2009-06-01 00:00:00
abstract::Visceral artery pseudoaneurysms are common complications of pancreatitis that carry a high mortality rate. Early detection and treatment of the pseudoaneurysms should be done as they carry high mortality following rupture. The splenic artery is the commonest artery involved followed by gastroduodenal and pancreaticodu...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章,评审
doi:10.1177/1538574420954309
更新日期:2021-01-01 00:00:00
abstract::Although uncommon, hoarseness can be a presenting symptom of a thoracic aneurysm. We present a case of a 67-year-old man with hoarseness, subsequently found to have left vocal paralysis. On workup, a computed tomography scan demonstrated a saccular thoracic aneurysm compressing the recurrent laryngeal nerve at the aor...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章,评审
doi:10.1177/1538574408324616
更新日期:2009-04-01 00:00:00
abstract::Vascular abnormalities in neurofibromatosis type 1 (NF-1) are rare but sometimes fatal. We report a case of spontaneous rupture of a left renal artery aneurysm in a patient with NF-1. A 41-year-old nonpregnant normotensive woman known to have NF-1 presented to our emergency department with left flank pain. Computed to...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574413495465
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Remote endarterectomy is a less invasive technique compared with supragenicular bypass surgery for superficial femoral artery (SFA) occlusive disease. Early restenosis remains one of the drawbacks of this procedure. To prevent restenosis following remote endarterectomy, concomitant cryoplasty of the desobstru...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章,多中心研究
doi:10.1177/1538574409347397
更新日期:2010-01-01 00:00:00
abstract::Patients with central venous occlusion who are ''tunneled catheter dependent'' are a challenge for hemodialysis access. A relatively new option for them is the hemodialysis reliable outflow (HeRO) device that can be totally implanted subcutaneously. However, patients still require a tunneled hemodialysis catheter that...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574410377122
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Lymphaticovenular anastomosis (LVA) is becoming a treatment option for lymphedema. It is challenging to perform LVA when a lymphatic vessel is too far from a vein to anastomose directly. METHODS:We applied vein grafting for simultaneous multisite LVA (SM-LVA), when there was a considerable distance between ...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574415614402
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:To present a case of aortic sac occlusion using an Amplatzer vascular plug II (AVP). CASE REPORT:A patient with sigmoid malignancy and an infrarenal aortic aneurysm ultimately required an axillobifemoral graft for acute limb ischemia. The sac was ligated at subsequent laparotomy. Persistent filling of the sac ...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574411433297
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:After surgical or endovascular revascularization, some ischemic lesions will not heal, while some others will heal at a variable period of time from the intervention, indicating a multifactorial interaction between local and systematic "wound healing-promoting" factors. Our objective was to identify predicto...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章,评审
doi:10.1177/1538574419868863
更新日期:2019-11-01 00:00:00
abstract::We report a case of an abdominal aortic aneurysm (AAA) that underwent inflammatory transformation which we treated medically with corticosteroids. Medical therapy resulted in resolution of presenting symptoms and observed inflammatory changes. We review the clinical features, associated pathology, diagnostic, and ther...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章,评审
doi:10.1177/1538574413510616
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:A 24-hour venous duplex ultrasound (VDU) for suspected deep vein thrombosis (DVT) imposes significant resource burdens on a hospital. We hypothesize that termination of after-hours services increases empiric therapy without affecting clinical outcomes. METHODS:A retrospective review of patients evaluated by ...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574410365731
更新日期:2010-07-01 00:00:00
abstract::Medline was searched for studies investigating the perioperative and long-term results that derive from statin use in patients with abdominal aortic aneurysm and the clinical and experimental evidence dealing with aneurysm expansion. Data suggest that statins improve the perioperative and long-term outcomes of aneurys...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574407308205
更新日期:2008-04-01 00:00:00
abstract::One of the most feared complications following vascular reconstruction is infection due to the attendant risks of limb loss, sepsis, or death. The reported incidence of infection following infrainguinal prosthetic graft infection is 2.5% with associated mortality rates and amputation rates of 18% and 41%, respectively...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574408326265
更新日期:2009-06-01 00:00:00
abstract::Popliteal artery injury is a known but rare complication of elective orthopedic procedures. This case report describes the diagnosis and treatment of a popliteal artery pseudoaneurysm and arteriovenous fistula after a tibial lengthening osteotomy in a 7-year-old boy. ...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574408320023
更新日期:2008-12-01 00:00:00
abstract::First bite syndrome (FBS) is a sharp unilateral pain in the vicinity of the angle of the mandible after taking the first bite of a meal that presents typically after surgery in the area of the ipsilateral parapharyngeal space. It is not confirmed what the pathophysiology is that causes this pain, but the proposed mech...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章,评审
doi:10.1177/1538574420954589
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:Type A acute aortic dissection is a surgical emergency, and supra-aortic trunk involvement may be complicated by stroke in 6% to 20% of cases. A 66-year-old Caucasian female patient underwent a composite repair of the ascending aorta for type A aortic dissection. Postoperative period was complicated by episodes...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574411414301
更新日期:2011-10-01 00:00:00
abstract::Patients with end-stage renal disease (ESRD) who present with critical limb ischemia (CLI) have become an increasingly common and complex treatment problem for vascular surgeons. Dialysis patients have high short-term mortality rates regardless of whether revascularization is pursued. ESRD patients with CLI can be man...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574416674843
更新日期:2016-11-01 00:00:00
abstract::Although the radial artery has proven to be a reliable conduit for arterial bypass procedures in cardiac surgery, its use in lower extremity revascularization has been limited due to its length. In patients who have undergone multiple cardiovascular procedures, venous conduit options can be limited, and infrapopliteal...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574407299807
更新日期:2007-08-01 00:00:00
abstract::Thoracic endografting offers many advantages over open repair. However, delivery of the device can be difficult and may necessitate adjunctive procedures. We describe our techniques for preserving perfusion to the left subclavian artery despite endograft coverage to obtain a proximal seal zone. We reviewed our experie...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574406293735
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:To examine the results of open or endovascular abdominal aortic aneurysm (AAA) repair following prior open or endovascular thoracic aortic surgery. METHODS:A retrospective review of all patients who underwent AAA repair in a delayed fashion following prior thoracic aortic surgery at a single university hospi...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574412474500
更新日期:2013-02-01 00:00:00
abstract::Inadvertent complications of jugular vein catheterization are not uncommon, however, a persistent symptomatic carotid-jugular fistula has been rarely reported. A 72-year-old male with infected surgical wound after coxofemoral disarticulation for sarcoma presented with symptoms of acute right heart failure. A fistula b...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574416675675
更新日期:2016-11-01 00:00:00
abstract:INTRODUCTION:The use of fenestrated and branched endovascular technologies in complex aortic aneurysm repair (F/BEVAR) is increasing, with a trend toward using longer sealing zones and incorporating more target vessels. Successful aneurysm exclusion and prevention of long-term treatment failure need to be balanced agai...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574418823594
更新日期:2019-05-01 00:00:00
abstract::Takayasu arteritis is a rare, chronic vasculitis of unknown etiology characterized by inflammation of the aorta and its main branches. Although Takayasu arteritis mostly affects women of childbearing age, there is a paucity in the literature on pregnancy associated with Takayasu arteritis. Pregnant patients are at inc...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574417698904
更新日期:2017-05-01 00:00:00
abstract::Cystic adventitial disease (CAD) is a rare vascular pathology which predominantly affects peripheral vessels of young otherwise healthy males. Much debate exists regarding its exact etiology. It is characterized by a collection of mucinous material within the adventitial wall layer of the affected vessel, resulting in...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章,评审
doi:10.1177/1538574417722921
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:Treatment options after arteriovenous fistula (AVF) associated steal include ligation, banding, and distal revascularization-interval ligation (DRIL). The purpose of this study was to evaluate the arterial pressure gradients in upper extremity steal syndrome. METHODS:Preoperative arteriography and sequential i...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574410376450
更新日期:2010-11-01 00:00:00
abstract:AIM:The aim of the study is to determine whether presentation and outcomes of inflammatory abdominal aortic aneurysms (IAAA) have changed over the last five decades. METHODS:Comparison of current outcomes (January 2001 to December 2007) with results of the earliest report from our unit in 1972. RESULTS:In contemporar...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574409335915
更新日期:2009-08-01 00:00:00
abstract::A 26-year-old male soldier was clinically characterized by transient fever, persistent right upper quadrant pain, hypertension, and elevated inflammatory biomarkers associated with bacterial infection. On the fifteenth day after the onset of symptoms, he had typical CT findings in polyarteritis nodosa involving only t...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章
doi:10.1177/1538574420968682
更新日期:2020-10-21 00:00:00
abstract::Mycotic aneurysms of the internal carotid artery (ICA) are rare and often difficult to diagnose. They can have nonspecific signs and symptoms, an unclear etiology, and can lead to severe morbidity and mortality if left untreated. We present a case of a 47-year-old woman with an apparent mycotic aneurysm of the extracr...
journal_title:Vascular and endovascular surgery
pub_type: 杂志文章,评审
doi:10.1177/1538574409340590
更新日期:2009-08-01 00:00:00