Abstract:
:Autologous fat grafting (lipofilling) enables repair and augmentation of soft tissues and is increasingly used both in aesthetic and reconstructive surgery. Autologous fat has several advantages, including biocompatibility, versatility, natural appearance, and low donor site morbidity. The main limitation is unpredictable graft resorption, which ranges from 25%-80%, probably as a result of ischaemia and lack of neoangiogenesis. To obviate these disadvantages, several studies have searched for new ways of increasing the viability of the transplanted tissue. One promising approach has been to enrich the fat graft with adipose tissue-derived mesenchymal stem cells (ASC) before transplantation. We have reviewed original studies published on fat transplantation enriched with ASC. We found four murine and three human studies that investigated the subject after a sensitive search of publications. In the human studies, so-called cell assisted lipotransfer (CAL) increased the ASC concentration 2-5 times compared with non-manipulated fat grafts, which caused a questionable improvement in survival of fat grafts, compared with that of traditional lipofilling. In contrast, in two of the murine studies ASC-concentrations were increased 1250 and 6250 times, respectively, by ASC ex vivo expansion, which resulted in considerably improved fat transplant survival as well as quality. This effect of high-level enrichment with ASC is thought to have been caused by paracrine signalling, cellular differentiation, or both. The surgical and tissue handling techniques used in lipofilling are well proved, but the added effect of high-level enrichment with ex vivo expanded ASC still needs to be investigated properly in human lipofilling studies, combined with a thorough follow up and matched control groups. In conclusion, ASC-enriched lipofilling theoretically has the potential for transforming lipofilling from a relatively unpredictable intervention into one in which the resorption rate, quality of tissue, and safety can be predicted, and possibly superior to prosthetic implantation.
journal_name
J Plast Surg Hand Surgjournal_title
Journal of plastic surgery and hand surgeryauthors
Trojahn Kølle SF,Oliveri RS,Glovinski PV,Elberg JJ,Fischer-Nielsen A,Drzewiecki KTdoi
10.3109/2000656X.2012.668326subject
Has Abstractpub_date
2012-04-01 00:00:00pages
59-68issue
2eissn
2000-656Xissn
2000-6764journal_volume
46pub_type
杂志文章,评审abstract::Abdominal wall hernias are often diagnosed on clinical examination or encountered intraoperatively during an abdominoplasty. The aim of this study is to evaluate the long-term results of the use of dermal automesh for the repair of incidental hernias during abdominoplasty operations, and to perform a comparative analy...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2014.976571
更新日期:2015-06-01 00:00:00
abstract::Collagenase Clostridium histolyticum (CCH) is a non-surgical, efficacious therapy for Dupuytren's contracture (DC). This study evaluated the efficacy and safety of CCH in patients with previous DC surgery. Data from 12 CCH clinical trials were pooled. At screening, patients provided details about the type/date of prev...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,meta分析
doi:10.3109/2000656X.2012.683795
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:Toe-to-hand transplantation is a reliable procedure that replaces like-with-like in cases of a lost thumb or finger. The aim of this study is to investigate the effects of toe transplantation on patients from the perspectives of quality of life (QOL) and disability. METHODS:Ten patients with traumatic amputa...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2018.1520123
更新日期:2018-12-01 00:00:00
abstract::We compared an uncemented joint replacement (Elektra) with trapeziectomy (with ligament reconstruction and tendon interposition, LRTI) for the treatment of primary osteoarthritis in the first carpometacarpal joint (CMC1) in a randomised controlled trial. Forty patients were included (20 in each group) and followed for...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,随机对照试验
doi:10.1080/2000656X.2019.1635490
更新日期:2019-12-01 00:00:00
abstract::Radioulnar synostosis is rare, and exists in two forms: congenital and post-traumatic. The congenital form presents only in the proximal forearm, and the post-traumatic form may present anywhere along the radius and ulna. The only known aetiology for distal radioulnar synostosis is post-traumatic. We present a rare ca...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.754626
更新日期:2014-02-01 00:00:00
abstract::Irradiation of the recipient site has been associated with postoperative complications and an increased rate of flap failure in facial reconstruction. The aim of this study was to report the outcomes of our use of four different types of flaps (two free and two pedicled) for the reconstruction of patients with nasopha...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.729510
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:While Realdo Colombo from Cremona, Italy has, to date, been acknowledged to be the first to describe the possible absence of the palmaris longus muscle in men in 1559, the authors found this absence to be recorded in the first edition of "De Humani Corporis Fabrica Libri Septum" by Andreas Vesalius, publishe...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 历史文章,杂志文章
doi:10.3109/2000656X.2015.1073156
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Several authors have indicated that there are specific poor prognostic factors which may affect the outcome of management of phalangeal neck fractures. In the authors' centre, phalangeal neck fractures with any of these poor prognostic factors are labelled "troublesome". Any of the following five criteria wi...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1106408
更新日期:2016-01-01 00:00:00
abstract::Arthrodesis of the thumb metacarpophalangeal (MP) joint exhibits good results in rheumatoid patients but is controversial in post-traumatic conditions. This study evaluated the subjective outcome after thumb MP joint arthrodesis in chronic injuries and non-rheumatoid degenerative disorders. Forty-six patients were eva...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.742020
更新日期:2013-04-01 00:00:00
abstract::Y-V or Z-plasties are a useful one-stage technique for skin closure after aponeurotomy. However, we know no details about postoperative improvement, particularly at each joint. The purpose of this study was to evaluate the clinical outcomes of primary skin closure with Y-V and Z-plasties for Dupuytren's contracture. W...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2010.534340
更新日期:2010-12-01 00:00:00
abstract::Upper extremity body reshaping is a very frequent surgical procedure in massive weight loss patients. Many surgeons have presented different patterns of brachioplasty skin excision and a variety of adjunctive techniques, each of them claiming improvements in scar aesthetic, arm shape or overall safety of the procedure...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2018.1476363
更新日期:2018-10-01 00:00:00
abstract::A microvascular coupling system was developed and introduced for clinical application to facilitate fast and safe anastomosis of small vessels. However, operators often encounter some difficulty, particularly in pinning the vascular wall onto the ring-pins. To overcome the difficulty, the authors developed the "push d...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2014.882344
更新日期:2014-10-01 00:00:00
abstract::Post-operative complications pose a significant set-back for patients undergoing breast reconstruction. This study aims to characterize factors associated with postoperative complications following breast reconstruction using the National Surgical Quality Improvement Program (ACS-NSQIP) database from 2005-2010. The 20...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.819003
更新日期:2014-04-01 00:00:00
abstract::Scaphoid and lunate mobility has been suggested to be minimal during the dart-throwing motion in studies based on serial computed tomography (CT) scans and cadaver studies. This study analyzes the direct motion between the scaphoid and the lunate during the dart-throwing motion in vivo. We examined nine individuals wi...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2021.1874398
更新日期:2021-01-28 00:00:00
abstract::The rate of margins involvement and the associated recurrence risk in basal cell carcinomas (BCCs) varies widely in published works (7%-25% and 26%-67%, respectively). This study investigated the risk factors associated with incomplete excision and their relevance in surgical management when positive margins occur in ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.800526
更新日期:2014-02-01 00:00:00
abstract::We report three patients with an unusual pattern of rupture of the extensor tendon. All were found to have previously undiagnosed Kienböck disease. Radiographic study of the wrist is essential before treating any closed rupture of an extensor tendon. Lesions may be progressive and extend to adjacent tendons and should...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.668325
更新日期:2012-09-01 00:00:00
abstract::We report about reconstruction of the foot with an innervated distally-based superficial sural artery flap using the lateral sural cutaneous nerve. The sensation of the lateral part of the leg depends on the sural nerve (SN), and the medial part of the leg on the saphenous nerve. The border of the area between the SN ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2011.644720
更新日期:2012-02-01 00:00:00
abstract::The levator and frontalis muscles lack interior muscle spindles, despite consisting of slow-twitch fibres that involuntarily sustain eyelid-opening and eyebrow-raising against gravity. To compensate for this anatomical defect, this study hypothetically proposes that initial voluntary contraction of the levator fast-tw...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.718282
更新日期:2013-02-01 00:00:00
abstract:INTRODUCTION:In our study, we aimed to search and compare the effects of valsartan and enalapril on the pathological scar formation on the basis of histomorphological parameters. MATERIALS AND METHODS:Nine New Zealand albino male rabbits, which were divided into three groups, were included in the study. A previously d...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2020.1814312
更新日期:2020-12-01 00:00:00
abstract::Encephalocraniocutaneous lipomatosis (ECCL) is a rare neurocutaneous syndrome that include skin, ocular, and neurological disorders. This study describes the case of a 16-year-old girl that came to observation for the treatment of a congenital alopecia causing great psychological distress. After two expansion procedur...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.842293
更新日期:2014-12-01 00:00:00
abstract::Neoadjuvant treatment and surgical resection for sarcoma patients can often leave devastating wounds necessitating soft-tissue coverage in the form of free flaps. There is still debate as to the optimal flap for reconstruction of defects in irradiated fields. We aim to describe our experiences with free fasciocutaneou...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2020.1791893
更新日期:2020-12-01 00:00:00
abstract::The aim of this meta-analysis is to compare the outcomes of the Swanson and Sutter prostheses (previously the Avanta prosthesis) used for metacarpophalangeal joint arthroplasty, and provide a powerful and rational conclusion regarding the use of prosthesis in MCP joint surgery. The literature search was based on PubMe...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,meta分析
doi:10.3109/2000656X.2014.942313
更新日期:2015-02-01 00:00:00
abstract::We describe a rare anatomical variant of the thenar branch of the median nerve during open release of the carpal tunnel. The thenar branch originated from the ulnar side of the median nerve and traversed supraligamentously close to the top of the transverse ligament. A high resolution clinical photograph shows the rel...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/02844310903123379
更新日期:2010-12-01 00:00:00
abstract::It is difficult to determine if women with severe abdominal burn scar contractures can have uneventful pregnancies and births. There are few reports involving the relationship between severe abdominal scar contractures and pregnancy/childbirth. Furthermore, all of these reports are based on retrospective studies. The ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2014.942314
更新日期:2015-02-01 00:00:00
abstract::The role of nitric oxide (NO) on the microcirculation of arterialized venous flaps (AVFs) remains controversial. We aimed to investigate the effect of hemodynamic regulation using nitric oxide synthase (NOS) inhibitor and its agonist as a chemical intervention on the survival of AVF. A 10 × 8 cm arterialized venous fl...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2018.1550418
更新日期:2019-04-01 00:00:00
abstract::A slow-involuting segmental haemangioma was initially treated conventionally. Proliferation recurred when treatment was stopped. When the effect of propranolol on haemangiomas was published, we treated this 2.5- year- old girl with it. The haemangioma finally regressed recorded on magnetic resonance imaging and at cli...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.754622
更新日期:2014-02-01 00:00:00
abstract::The minimally-invasive nature of sclerotherapy makes it one of the first treatment options for venous malformations, although treatment-related complications, such as peripheral nerve paralysis, have been reported in some clinical cases. However, no studies of the aetiology of the detrimental effects of intraluminally...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.675881
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:The natural course and predictors for decreased cold hypersensitivity were studied in 85 patients with severe hand injuries involving nerve lesions. METHODS:Questionnaires including the McCabe Cold Sensitivity Severity scale (CSS 0-400) were collected after injury, and at 6-month, 12-month, 2-year, and 3-ye...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1089877
更新日期:2016-01-01 00:00:00
abstract::Congenital giant benign tumours of the back are rarely seen or reported. They pose two challenges to plastic surgeons: copious intraoperative bleeding, and an extensive raw area left after removal of the tumour. We have treated five cases of congenital giant benign tumour of the back. The largest was a neurofibroma in...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2011.631284
更新日期:2011-12-01 00:00:00
abstract::We present three patients with major defects of the eyelid who subsequently had them reconstructed. They included a defect of the lateral upper lid, a defect of the medial upper and lower lids, and a defect of the medial lower lid, cheek, and nose. ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/02844311.2010.504072
更新日期:2011-02-01 00:00:00