Abstract:
INTRODUCTION:In our study, we aimed to search and compare the effects of valsartan and enalapril on the pathological scar formation on the basis of histomorphological parameters. MATERIALS AND METHODS:Nine New Zealand albino male rabbits, which were divided into three groups, were included in the study. A previously described rabbit ear wound model was used. Enalapril was administered 0.75 mg/kg/day on the first group and valsartan was administered 10 mg/kg/day on the second group for 40 days. The third group was the control group. Results were evaluated on the 40th day with scar elevation index calculation and histological studies. Histological studies were done by using Hematoxylin-eosin, Masson trichrome and Sirius Red stains. RESULTS:Enalapril and valsartan groups were both significantly effective on the prevention of pathological scar formation when compared to the control group in terms of fibroblast count, capillary count, type 1/3 collagen ratio, collagen organization, and epithelial thickness. There was no significant difference between the enalapril and control group on the scar elevation index. Valsartan group was more efficient than the enalapril group on the reduction of fibroblast count and epithelial thickness. CONCLUSION:Both Valsartan and Enalapril are found to be effective for the prevention of pathological scar formation.
journal_name
J Plast Surg Hand Surgjournal_title
Journal of plastic surgery and hand surgeryauthors
Kurt M,Akoz Saydam F,Bozkurt M,Serin M,Caglar Adoi
10.1080/2000656X.2020.1814312subject
Has Abstractpub_date
2020-12-01 00:00:00pages
382-387issue
6eissn
2000-656Xissn
2000-6764journal_volume
54pub_type
杂志文章abstract::Experimental results have previously been reported for a new biological dressing consisting of concentrated plasma proteins and platelet-rich plasma (PRP), which is named Platelet-Protein film (PPF). This study reports clinical experience using PPF produced from the patients' own blood by the original technique. Ten p...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 临床试验,杂志文章
doi:10.3109/2000656X.2013.783485
更新日期:2013-12-01 00:00:00
abstract::Y-V or Z-plasties are a useful one-stage technique for skin closure after aponeurotomy. However, we know no details about postoperative improvement, particularly at each joint. The purpose of this study was to evaluate the clinical outcomes of primary skin closure with Y-V and Z-plasties for Dupuytren's contracture. W...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2010.534340
更新日期:2010-12-01 00:00:00
abstract::Deep inferior epigastric artery perforator (DIEP) flap has become the gold standard in autologous breast reconstruction. Attention is now being focused on the impact of DIEP flap harvest technique on abdominal hernia rates. The aim of this study was to evaluate DIEP abdominal wall morbidity in relation to flap harvest...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2018.1498790
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the efficacy of suction-assisted liposuction (SAL) in Simon grade 2b gynecomastia and its effect on sternal notch to nipple areola (SNN) distance. METHODS:A retrospective analysis was performed on 21 patients with grade 2b gynecomastia who underwent SAL. Preoperative and p...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2017.1313260
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Venous thromboembolism is a well-documented complication of surgery, including plastic surgery. However, few consensus guidelines on thromboembolism prophylaxis exist in plastic surgery and, thus, the different approaches in the public as well as the private clinics in Denmark were investigated using a web-b...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2016.1195745
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:The internal mammary artery (IMA) is one of the most popular recipients for microsurgical breast reconstruction. However, it is often separated into sleeve-like layers when it is handled. This study tried to explain this unique behaviour of the IMA through histologic observation. METHODS:Nine pairs of IMAs ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1021815
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Despite current advances in microsurgery, fingertip replantation is still controversial, mainly due to its difficulty and cost. The purpose of this study is to describe a new technique of interposition vein graft guided by polypropylene suture in distal fingertip replantation. METHODS:A total of eight conse...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1041968
更新日期:2015-10-01 00:00:00
abstract::The purpose of this study was to investigate the correlation between the oculocardiac reflex (OCR) and blepharoptosis surgery for safe eyelid surgery. Fifty-four consecutive patients with bilateral aponeurotic blepharoptosis were enrolled in this study. Changes in electrocardiography (ECG) monitoring were recorded dur...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.836529
更新日期:2014-06-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.787935
更新日期:2013-12-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.819003
更新日期:2014-04-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.812763
更新日期:2014-12-01 00:00:00
abstract::We present three patients with major defects of the eyelid who subsequently had them reconstructed. They included a defect of the lateral upper lid, a defect of the medial upper and lower lids, and a defect of the medial lower lid, cheek, and nose. ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/02844311.2010.504072
更新日期:2011-02-01 00:00:00
abstract::The aim of this meta-analysis is to compare the outcomes of the Swanson and Sutter prostheses (previously the Avanta prosthesis) used for metacarpophalangeal joint arthroplasty, and provide a powerful and rational conclusion regarding the use of prosthesis in MCP joint surgery. The literature search was based on PubMe...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,meta分析
doi:10.3109/2000656X.2014.942313
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abstract::Crouzon syndrome presents with craniosynostosis, maxillary hypoplasia, exophtalmus, and sometimes hampered neuropsychological development. The aim of the present study was to evaluate the quality of life for adult patients with Crouzon syndrome. Forty patients with Crouzon syndrome born before 1990 could be identified...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.868811
更新日期:2014-08-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.698416
更新日期:2012-09-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2011.569198
更新日期:2011-06-01 00:00:00
abstract::Previous authors have used either a grasping or a locking technique for flexor tendon repair in zone II. A combined (grasping and locking) 10-strand repair was used by the author in 22 adults (n = 28 fingers) with lacerations of both flexor tendons in zone II. The combined repair is known to be strong (mean tensile st...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.776561
更新日期:2013-12-01 00:00:00
abstract::Throughout different eras and cultures what is considered the cosmetically ideal breast has varied greatly. There is no broadly accepted standardised method that objectively evaluates aesthetic outcome after breast reduction mammoplasty. The primary aim of this study was to evaluate the result of breast reduction rega...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2017.1419142
更新日期:2018-08-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,评审
doi:10.1080/2000656X.2017.1345751
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.753080
更新日期:2013-09-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1020314
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.729652
更新日期:2013-04-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2020.1791893
更新日期:2020-12-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1089876
更新日期:2016-01-01 00:00:00
abstract::A slow-involuting segmental haemangioma was initially treated conventionally. Proliferation recurred when treatment was stopped. When the effect of propranolol on haemangiomas was published, we treated this 2.5- year- old girl with it. The haemangioma finally regressed recorded on magnetic resonance imaging and at cli...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.754622
更新日期:2014-02-01 00:00:00
abstract::The use of an infusion pain pump with local wound catheters has increased among different surgical specialities. Autologous breast reconstruction with deep inferior epigastric perforator (DIEP) and transverse rectus abdominis myocutaneous (TRAM) flaps may cause severe abdominal donor site morbidity, and infusion devic...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,meta分析,评审
doi:10.3109/2000656X.2013.788508
更新日期:2013-12-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1089877
更新日期:2016-01-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.852100
更新日期:2014-06-01 00:00:00
abstract::The role of nitric oxide (NO) on the microcirculation of arterialized venous flaps (AVFs) remains controversial. We aimed to investigate the effect of hemodynamic regulation using nitric oxide synthase (NOS) inhibitor and its agonist as a chemical intervention on the survival of AVF. A 10 × 8 cm arterialized venous fl...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2018.1550418
更新日期:2019-04-01 00:00:00
abstract::Upper extremity body reshaping is a very frequent surgical procedure in massive weight loss patients. Many surgeons have presented different patterns of brachioplasty skin excision and a variety of adjunctive techniques, each of them claiming improvements in scar aesthetic, arm shape or overall safety of the procedure...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2018.1476363
更新日期:2018-10-01 00:00:00