The effects of valsartan on scar maturation in an experimental rabbit ear wound model.

Abstract:

INTRODUCTION:In our study, we aimed to search and compare the effects of valsartan and enalapril on the pathological scar formation on the basis of histomorphological parameters. MATERIALS AND METHODS:Nine New Zealand albino male rabbits, which were divided into three groups, were included in the study. A previously described rabbit ear wound model was used. Enalapril was administered 0.75 mg/kg/day on the first group and valsartan was administered 10 mg/kg/day on the second group for 40 days. The third group was the control group. Results were evaluated on the 40th day with scar elevation index calculation and histological studies. Histological studies were done by using Hematoxylin-eosin, Masson trichrome and Sirius Red stains. RESULTS:Enalapril and valsartan groups were both significantly effective on the prevention of pathological scar formation when compared to the control group in terms of fibroblast count, capillary count, type 1/3 collagen ratio, collagen organization, and epithelial thickness. There was no significant difference between the enalapril and control group on the scar elevation index. Valsartan group was more efficient than the enalapril group on the reduction of fibroblast count and epithelial thickness. CONCLUSION:Both Valsartan and Enalapril are found to be effective for the prevention of pathological scar formation.

journal_name

J Plast Surg Hand Surg

authors

Kurt M,Akoz Saydam F,Bozkurt M,Serin M,Caglar A

doi

10.1080/2000656X.2020.1814312

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

382-387

issue

6

eissn

2000-656X

issn

2000-6764

journal_volume

54

pub_type

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