Abstract:
:The role of nitric oxide (NO) on the microcirculation of arterialized venous flaps (AVFs) remains controversial. We aimed to investigate the effect of hemodynamic regulation using nitric oxide synthase (NOS) inhibitor and its agonist as a chemical intervention on the survival of AVF. A 10 × 8 cm arterialized venous flap was designed symmetrically on the rabbit abdomen. Thirty-six rabbits were used and randomly divided into three groups: control group, L-arg group and L-NAME group, respectively. The L-arg group and the L-NAME group received intraperitoneal injections of L-arginine (a NOS agonist, 1 g/kg/d) and L-NAME (nitro-L-arginine-methyl ester, a NOS inhibitor, 50 mg/kg/d) respectively, whereas the control group received intraperitoneal injections of the same amount of saline. Flap viability, water content, status of vascular perfusion and gene expression of eNOS and HIF-1α in each group were observed and analyzed. The average value of water content (venous congestion) in the L-arg group was the highest in comparison with the control group and the L-NAME group with a statistically significant difference (all p < .001). Similar results regarding blood perfusion state, gene expression of eNOS and HIF-1α and flap survival status were found among the three groups. The early application of L- NAME as a chemical hemodynamic intervention could stop the cascade of flap swelling, congestion and necrosis due to overexpression of NO and be beneficial to the AVF survival. Our findings may develop a new strategy as a solution for the inconsistent survival of AVFs.
journal_name
J Plast Surg Hand Surgjournal_title
Journal of plastic surgery and hand surgeryauthors
Zhao B,Poonit K,Zhou X,Yao C,Sun C,Yan Hdoi
10.1080/2000656X.2018.1550418subject
Has Abstractpub_date
2019-04-01 00:00:00pages
83-88issue
2eissn
2000-656Xissn
2000-6764journal_volume
53pub_type
杂志文章abstract::A slow-involuting segmental haemangioma was initially treated conventionally. Proliferation recurred when treatment was stopped. When the effect of propranolol on haemangiomas was published, we treated this 2.5- year- old girl with it. The haemangioma finally regressed recorded on magnetic resonance imaging and at cli...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.754622
更新日期:2014-02-01 00:00:00
abstract::Deep inferior epigastric artery perforator (DIEP) flap has become the gold standard in autologous breast reconstruction. Attention is now being focused on the impact of DIEP flap harvest technique on abdominal hernia rates. The aim of this study was to evaluate DIEP abdominal wall morbidity in relation to flap harvest...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2018.1498790
更新日期:2018-12-01 00:00:00
abstract::Microvascular free flap transfer has become a prevailing surgery with a failure rate of <5%. However, pedicle thrombosis occurs more frequently than indicated by the failure rate. This difference is due to the successful salvage of failing flaps. During exploration, thrombi are often encountered at anastomotic sites, ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2018.1523177
更新日期:2018-12-01 00:00:00
abstract::We reconstructed an extensive soft tissue defect of the dorsum of the left wrist after an injury using a free anterolateral thigh flap and a tendon graft, and intending to substitute the extensor retinaculum for the fascia in this flap. As a result, maximum function of the extension mechanism was restored to the recon...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2010.544916
更新日期:2011-09-01 00:00:00
abstract::Crouzon syndrome presents with craniosynostosis, maxillary hypoplasia, exophtalmus, and sometimes hampered neuropsychological development. The aim of the present study was to evaluate the quality of life for adult patients with Crouzon syndrome. Forty patients with Crouzon syndrome born before 1990 could be identified...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.868811
更新日期:2014-08-01 00:00:00
abstract::Prosthesis-based techniques are the predominant form of breast reconstruction worldwide, with two-stage tissue expander procedures being the most popular. In the past decade, there has been increasing interest in performing single-stage implant reconstruction immediately following mastectomy as an attempt to simplify ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,多中心研究
doi:10.3109/2000656X.2013.767202
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the efficacy of suction-assisted liposuction (SAL) in Simon grade 2b gynecomastia and its effect on sternal notch to nipple areola (SNN) distance. METHODS:A retrospective analysis was performed on 21 patients with grade 2b gynecomastia who underwent SAL. Preoperative and p...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2017.1313260
更新日期:2018-02-01 00:00:00
abstract::Arthrodesis of the thumb metacarpophalangeal (MP) joint exhibits good results in rheumatoid patients but is controversial in post-traumatic conditions. This study evaluated the subjective outcome after thumb MP joint arthrodesis in chronic injuries and non-rheumatoid degenerative disorders. Forty-six patients were eva...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.742020
更新日期:2013-04-01 00:00:00
abstract::Breast ptosis commonly develops in response to ageing and breastfeeding. Clinical studies now focus on both filling the upper pole of the breast with parenchymal flaps and long-term maintenance of the breast projection without recurrence of upper pole concavity and a significant change in breast shape over time. This ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.753080
更新日期:2013-09-01 00:00:00
abstract::Background: Island flaps are more mobile than local flaps in-continuity and rely on the laxity of the adjacent tissues. We present a new island flap design, called the inverted love-heart flap, used to reconstruct cutaneous defects of the limbs.Methods: A retrospective chart review of patients who underwent inverted l...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2019.1688164
更新日期:2020-02-01 00:00:00
abstract::Abdominoplasty is a well-established operation to remove abdominal tissue excess. The patients' benefits and risks of this surgical treatment are, however, incompletely studied. The aim of this study was to evaluate the quality of evidence of benefits and risks for patients having abdominoplasty from massive weight lo...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,评审
doi:10.3109/2000656X.2012.683794
更新日期:2012-09-01 00:00:00
abstract::Experimental results have previously been reported for a new biological dressing consisting of concentrated plasma proteins and platelet-rich plasma (PRP), which is named Platelet-Protein film (PPF). This study reports clinical experience using PPF produced from the patients' own blood by the original technique. Ten p...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 临床试验,杂志文章
doi:10.3109/2000656X.2013.783485
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The natural course and predictors for decreased cold hypersensitivity were studied in 85 patients with severe hand injuries involving nerve lesions. METHODS:Questionnaires including the McCabe Cold Sensitivity Severity scale (CSS 0-400) were collected after injury, and at 6-month, 12-month, 2-year, and 3-ye...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1089877
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Premature sagittal synostosis (SS) can be surgically corrected using extensive cranioplasties or using less invasive methods, e.g. spring-assisted surgery (SAS). AIM:The aim of the present study was to perform a proper systematic review of springs in the treatment of SS. METHODS:A literature search was per...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,评审
doi:10.3109/2000656X.2014.981268
更新日期:2015-06-01 00:00:00
abstract::Many authors have advocated early surgical intervention to avoid muscle degeneration in patients with blowout fractures with evidence of extraocular muscle entrapment imaged under computed tomography. However, there is still no golden standard with regard to the target timing of operations for releasing extraocular mu...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.779581
更新日期:2013-12-01 00:00:00
abstract::Dysphagia is an important postoperative problem in patients with oral cancer. We evaluated the usefulness of a technique to modify the flap and scar for the alleviation of swallowing disorders. The modifications were made while tongue pressure was being measured to improve excursion of the residual tongue in nine pati...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2011.569198
更新日期:2011-06-01 00:00:00
abstract::We report three patients with an unusual pattern of rupture of the extensor tendon. All were found to have previously undiagnosed Kienböck disease. Radiographic study of the wrist is essential before treating any closed rupture of an extensor tendon. Lesions may be progressive and extend to adjacent tendons and should...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.668325
更新日期:2012-09-01 00:00:00
abstract::We describe a 53-year-old woman who had a huge pleomorphic liposarcoma of the left breast. She had a left Halstead mastectomy, which left a huge defect in the chest wall. We did an immediate reconstruction of the chest wall with combined latissimuss dorsi musculocutaneous (for the upper half of the defect) and vertica...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.748309
更新日期:2013-04-01 00:00:00
abstract::Emergency replantation and revascularization operations of upper extremity injuries demand considerable resources, but their actual occurrence is unknown. This study evaluated all emergency replantations and revascularizations in the upper extremity in Finland from 1998 to 2016. A total of 2,434 operations were identi...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2020.1771720
更新日期:2020-10-01 00:00:00
abstract::Patients who sustain facial injury and who require an operation may be at greater risk for developing psychological distress and maladaptive coping. The purpose of this study was to examine psychological responses in adult victims of facial trauma after operation. A consecutive group of adult patients attending specia...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.718715
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the accelerating effects of platelet-rich plasma-containing (PRP&) fragmin/protamine microparticles (F/P MPs) for repairing mitomycin C-treated healing-impaired wounds. Staining with terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL-staining)...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1034723
更新日期:2015-10-01 00:00:00
abstract::The levator and frontalis muscles lack interior muscle spindles, despite consisting of slow-twitch fibres that involuntarily sustain eyelid-opening and eyebrow-raising against gravity. To compensate for this anatomical defect, this study hypothetically proposes that initial voluntary contraction of the levator fast-tw...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.718282
更新日期:2013-02-01 00:00:00
abstract:INTRODUCTION:In our study, we aimed to search and compare the effects of valsartan and enalapril on the pathological scar formation on the basis of histomorphological parameters. MATERIALS AND METHODS:Nine New Zealand albino male rabbits, which were divided into three groups, were included in the study. A previously d...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2020.1814312
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Carpal tunnel syndrome (CTS) and trigger digits are among the most common nontraumatic hand disorders treated by plastic surgeons. The onset of trigger digits after carpal tunnel release (CTR) has been inconsistently reported. This systematic review assessed the prevalence of trigger digits development in pa...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,评审
doi:10.1080/2000656X.2017.1345751
更新日期:2018-04-01 00:00:00
abstract::Collagenase Clostridium histolyticum (CCH) is a non-surgical, efficacious therapy for Dupuytren's contracture (DC). This study evaluated the efficacy and safety of CCH in patients with previous DC surgery. Data from 12 CCH clinical trials were pooled. At screening, patients provided details about the type/date of prev...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,meta分析
doi:10.3109/2000656X.2012.683795
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:This study evaluated the composite graft survival rate in distal digital amputations with respect to injury type and amputation level. METHODS:Twenty-seven patients with complete fingertip amputations (32 digits) distal to the distal interphalangeal joint who were treated by composite grafting from January 201...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1020314
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Possible factors associated with failure of free gracilis flaps were studied. MATERIALS AND METHODS:All gracilis free flaps used to reconstruct acute traumatic leg defects in a 5 year period were collected. This included open fractures of the tibia and/or fibula in which a gracilis free flap was used for re...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1119697
更新日期:2016-06-01 00:00:00
abstract::We report about reconstruction of the foot with an innervated distally-based superficial sural artery flap using the lateral sural cutaneous nerve. The sensation of the lateral part of the leg depends on the sural nerve (SN), and the medial part of the leg on the saphenous nerve. The border of the area between the SN ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2011.644720
更新日期:2012-02-01 00:00:00
abstract::Bovine-derived collagen has been used for soft-tissue augmentation since 1977. However, there are issues regarding the possibility of bovine spongiform encephalopathy (BSE). Researchers discovered that the histologic structure of porcine-derived collagen is similar to that of human dermal collagen and that it is free ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/2000656X.2014.964725
更新日期:2015-06-01 00:00:00
abstract::Mycobacterium marinum infection of the hand is rare. We report the case of a 39-year-old man with M marinum infection that resulted in a chronic soft tissue infection, extensor tendon synovitis, and arthritis of the metacarpophalangeal (MCP) joints. The cause was probably tropical freshwater fishes. ...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.779801
更新日期:2013-12-01 00:00:00