Abstract:
:Polysialic acid (polySia) is a carbohydrate polymer critical for neuronal cell migration and axon pathfinding in embryonic development. Besides brain regions requiring persistent neuronal plasticity, polySia is essentially absent from the adult body. However, polySia is aberrantly re-expressed on many tumours, where it decorates the surface of NCAM (neuronal cell adhesion molecule) and modulates cell adhesion, migration and invasion. PolySia-NCAM expression is strongly associated with poor clinical prognosis and correlates with aggressive and invasive disease in many cancers, including lung cancer, neuroblastoma and gliomas. The synthesis of polySia is mediated by two polysialyltransferases (polySTs), ST8SiaIV (PST) and particularly ST8SiaII (STX) in cancer cells. The demonstration that polyST knock-down negates events associated with tumour cell dissemination indicates that PST and STX are validated targets. Selective inhibition of polySTs therefore presents a therapeutic opportunity to inhibit tumour invasion and metastasis.
journal_name
Curr Cancer Drug Targetsjournal_title
Current cancer drug targetsauthors
Falconer RA,Errington RJ,Shnyder SD,Smith PJ,Patterson LHdoi
10.2174/156800912803251225subject
Has Abstractpub_date
2012-10-01 00:00:00pages
925-39issue
8eissn
1568-0096issn
1873-5576pii
CCDT-EPUB-20120330-007journal_volume
12pub_type
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journal_title:Current cancer drug targets
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