Abstract:
:Angiotensin II (Ang II), a main effector peptide of the renin-angiotensin system (RAS), mediates a hormonal action in the maintenance of blood pressure and electrolyte levels, and thus fluid homeostasis. Ang II also mediates paracrine, autocrine and/or intracrine actions in the control of various specific functions of diverse tissue organs. In the pancreas, Ang II exerts a growth promoting, angiogenic influence via the mediation of angiotensin II type 1 receptor (AT1R). Recent studies have implicated inappropriate activation of the local RAS in pancreatic cancer, including upregulation of AT1R and the angiotensin-converting enzyme (ACE), which consequently enhance Ang II-induced tumour activity. In addition to acting in a classical antihypertensive capacity, RAS blockers (AT1R blockers or ACE inhibitors) may yield protective effects against pancreatic cancer, a highly aggressive malignancy that is intrinsically resistant to radiotherapy and chemotherapy. Substantial experimental data from studies using cell and animal models of pancreatic cancer support the notion that RAS regulates tumour growth, angiogenesis, and metastasis; and a convergence of such findings suggests that pharmacological RAS blockade could have therapeutic potential in the management of pancreatic cancer. This review critically appraises the current research progress on the role of RAS in pancreatic cancer, and discusses the potential for developing drugs that target RAS for treatment of pancreatic cancer.
journal_name
Curr Cancer Drug Targetsjournal_title
Current cancer drug targetsauthors
Lau ST,Leung PSdoi
10.2174/156800911795538110subject
Has Abstractpub_date
2011-05-01 00:00:00pages
412-20issue
4eissn
1568-0096issn
1873-5576pii
EPub-Abstract-CCDT-123journal_volume
11pub_type
杂志文章,评审abstract::Prevention is one of the most important and promising strategies to control cancer. Many dietary bioactive compounds, mostly phytochemicals, have been found to decrease the risk of carcinogenesis. Modulating the metabolism and disposition pathways of carcinogens represents one of the major mechanisms by which dietary ...
journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
doi:10.2174/156800907781386669
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
pub_type: 杂志文章
doi:10.2174/156800912802429364
更新日期:2012-09-01 00:00:00
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
doi:10.2174/15680096113139990082
更新日期:2013-10-01 00:00:00
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journal_title:Current cancer drug targets
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doi:10.2174/1568009615666150506093155
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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abstract::Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medicat...
journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:Current cancer drug targets
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更新日期:2007-12-01 00:00:00