Abstract:
BACKGROUND:Most important cause of treatment failure and emergence of drug resistance in the treatment of tuberculosis is noncompliance. Compliance can be improved by direct observation of drug intake, intermittent therapy, and short-course treatment. The efficacy of Directly Observed Treatment Short Course (DOTS) strategy advocated by World Health Organization (WHO) in spinal tuberculosis is not yet proven. We conducted a prospective clinical study on a consecutive series of patients with spinal tuberculosis treated by Category I Revised National Tuberculosis Control Programme (RNTCP) regimen based on DOTS strategy of WHO from 2004 to 2007 to evaluate the efficacy. MATERIALS AND METHODS:Forty-nine consecutive patients of spinal tuberculosis were treated with short-course intermittent chemotherapy under Category I RNTCP/DOTS strategy. Patients were followed up for a minimum period of 2 years. Surgery was done if the patient presented with significant neurologic deficit or when the drug treatment failed. Outcome was assessed by clinical, radiologic, and laboratory criteria, and graded into excellent, good, fair, and poor based on various parameters. RESULTS:63.4% (n=26) of the patients had excellent results. 14.6% (n=6) of the patients had good and fair results. Three patients (7.3%) had poor results 48.7% (n=20) of the patients had but only one of them was severe enough to warrant change of drug. CONCLUSIONS:Efficacy of DOTS was comparable with other standard regimens. There was a significant reduction in adverse side effects when compared with daily regimens. Study showed that the outcome was better in those treated early.
journal_name
Indian J Orthopjournal_title
Indian journal of orthopaedicsauthors
Valsalan R,Purushothaman R,Raveendran M,Zacharia B,Surendran Sdoi
10.4103/0019-5413.93673subject
Has Abstractpub_date
2012-03-01 00:00:00pages
138-44issue
2eissn
0019-5413issn
1998-3727pii
IJOrtho-46-138journal_volume
46pub_type
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更新日期:2016-09-01 00:00:00
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更新日期:2009-07-01 00:00:00
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