Abstract:
Background:This study aimed at evaluating the imaging findings of phosphaturic mesenchymal tumors and tumor-induced osteomalacia and assess the clinical and biochemical profiles of patients with tumor-induced osteomalacia. Materials and methods:Imaging findings in six patients with tumor-induced osteomalacia and histopathologically proven phosphaturic mesenchymal tumors were evaluated. Clinical and biochemical profiles of these patients were also assessed. Results:Along with having a characteristic biochemical profile, patients with phosphaturic mesenchymal tumors also have certain imaging findings which can aid in the diagnosis such as increased uptake on DOTA PET-CT and homogeneous post-contrast enhancement on CT and MRI. Conclusion:Patients with tumor-induced osteomalacia have characteristic symptoms, imaging and biochemical profiles. For radiologists, raising the suspicion of a phosphaturic mesenchymal tumor in patients with refractory hypophosphatemic osteomalacia as well as localizing the tumor on imaging is crucial, as complete excision of the tumor leads to resolution of the osteomalacia and the patient's clinical symptoms.
journal_name
Indian J Orthopjournal_title
Indian journal of orthopaedicsauthors
Kawthalkar AS,Janu AK,Deshpande MS,Gala KB,Gulia A,Puri Adoi
10.1007/s43465-019-00005-5subject
Has Abstractpub_date
2020-01-13 00:00:00pages
215-223issue
2eissn
0019-5413issn
1998-3727pii
5journal_volume
54pub_type
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