Abstract:
:Perennial questions of evolutionary biology can be applied to gene regulatory systems using the abundance of experimental data addressing gene regulation in a comparative context. What is the tempo (frequency, rate) and mode (way, mechanism) of transcriptional regulatory evolution? Here we synthesize the results of 230 experiments performed on insects and nematodes in which regulatory DNA from one species was used to drive gene expression in another species. General principles of regulatory evolution emerge. Gene regulatory evolution is widespread and accumulates with genetic divergence in both insects and nematodes. Divergence in cis is more common than divergence in trans. Coevolution between cis and trans shows a particular increase over greater evolutionary timespans, especially in sex-specific gene regulation. Despite these generalities, the evolution of gene regulation is gene- and taxon-specific. The congruence of these conclusions with evidence from other types of experiments suggests that general principles are discoverable, and a unified view of the tempo and mode of regulatory evolution may be achievable.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Gordon KL,Ruvinsky Idoi
10.1371/journal.pgen.1002432subject
Has Abstractpub_date
2012-01-01 00:00:00pages
e1002432issue
1eissn
1553-7390issn
1553-7404pii
PGENETICS-D-11-01424journal_volume
8pub_type
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