Abstract：
OBJECTIVES:The main pathogenesis of acute lung injury induced by haemorrhagic shock is inflammation. BML-111, a lipoxinA(4)-receptor agonist, promotes acute inflammatory resolution. We sought to elucidate whether BML-111 protects haemorrhagic shock-induced acute lung injury in rats. METHODS:Thirty two adult male rats were randomized to sham group (sham), haemorrhagic shock/resuscitation (HS), HS plus BML-111 (BML-111), and HS plus BML-111 and BOC-2 (BOC-2). Haemorrhagic shock was induced by blood drawing, and then resuscitation was obtained by infusion of shed blood and two-fold volume saline. RESULTS:Histological findings, as well as assays of neutrophilic infiltration (myeloperoxidase activity, ICAM-1 expression), inflammatory cytokines and pro-inflammatory factor (IκB-α and NF-κB p65) confirmed that haemorrhagic shock induced acute lung injury. BML-111 significantly mitigated acute lung injury induced by haemorrhagic shock. However, BOC-2, an antagonist of the lipoxinA(4)-receptor, partially reversed the protective effect of BML-111 on the haemorrhagic shock-induced the acute lung injury. CONCLUSION:BML-111 protects haemorrhagic shock-induced acute lung injury in rats.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Gong J,Guo S,Li HB,Yuan SY,Shang Y,Yao SLdoi
10.1016/j.resuscitation.2011.12.035subject
Has Abstractpub_date
2012-07-01 00:00:00pages
907-12issue
7eissn
0300-9572issn
1873-1570pii
S0300-9572(12)00016-0journal_volume
83pub_type
杂志文章,随机对照试验相关文献
RESUSCITATION文献大全abstract：:The purpose of this study was to compare the rewarming effectiveness of a radio frequency coil (13.56 MHz) at a specific absorption rate (SAR) of 2.5 W/kg (RF) with warm water immersion (40 degrees C) (WW) and an insulated mummy-type insulating sack (IS) under simulated field conditions. Four male subjects, ages 24-35...
journal_title：Resuscitation
pub_type： 临床试验,杂志文章
doi：10.1016/0300-9572(94)00845-7
更新日期：1995-06-01 00:00:00
abstract：AIM:Extracorporeal cardiopulmonary resuscitation (ECPR) is an emerging therapy for refractory cardiac arrest. The purpose of this study was to analyze and report characteristics and outcomes of adult patients treated with ECPR after out-of-hospital cardiac arrest (OHCA) in a large international registry. METHODS:The E...
journal_title：Resuscitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.resuscitation.2017.08.003
更新日期：2017-10-01 00:00:00
abstract：AIM:Therapeutic hypothermia (TH) is widely used as a cardioprotective treatment for cardiac arrest. TH at 30-32°C during ischaemia and reperfusion has a cardioprotective effect. The aims of the study were to examine whether TH at 34°C with late induction (immediately after the start of reperfusion) has a cardioprotecti...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2011.08.013
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:this study determines the effect of prior hypothermia on the cardiovascular responses to norepinephrine (NE) after rewarming. METHODS:the experiment was a 2x2 controlled design with four groups of feline animals. The two variables were the presence or absence of previous cooling, and the use or non-use of NE...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(00)00185-4
更新日期：2000-08-01 00:00:00
abstract：BACKGROUND:The incidence of ventricular fibrillation (VF) out-of-hospital cardiac arrest (OHCA) treated by first responders has declined over the past decade. Since VF OHCA occurs primarily in the setting of severe coronary artery disease, primary and secondary prevention strategies may in part account for the decline....
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2005.04.015
更新日期：2005-10-01 00:00:00
abstract：INTRODUCTION:Therapeutic hypothermia (TH) is standard of care after ventricular fibrillation cardiac arrest (CA). Continuous EEG monitoring (cEEG) is increasingly used during TH. Analysis regarding value of cEEG utilization in this population in the context of cost and outcome has not been performed. We compared outcom...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2014.01.019
更新日期：2014-06-01 00:00:00
abstract：:We describe two cases of sudden infant death syndrome (SIDS) and one case of apparent life threatening apnoea where resuscitation was attempted by the mouth-to-mouth route. This was associated with evidence of gastric distension, including reflux of milk into the airway in the first two cases. In the second case the m...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(00)00257-4
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:Despite significant advances in resuscitation efforts, there are some patients who remain in ventricular fibrillation (VF) after multiple shocks during out-of-hospital cardiac arrest (OHCA). Double sequential external defibrillation (DSED) has been proposed as a treatment option for patients in refractory VF...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2019.04.038
更新日期：2019-06-01 00:00:00
abstract：:We studied cardiovascular changes and neurologic outcome at 72 h in 42 healthy dogs after normothermic ventricular fibrillation cardiac arrest (no blood flow) of 7.5, 10, or 12.5 min duration, reversed by standard external cardiopulmonary resuscitation (CPR) (< or = 10 min) and followed by controlled ventilation to 20...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(93)90003-9
更新日期：1993-02-01 00:00:00
abstract：:Extracorporeal life support has been used as an extension of conventional cardiopulmonary resuscitation (CPR). However, the appropriate indications for extracorporeal CPR (ECPR) including the duration of CPR are unknown. We present a case of a male, 37-year-old out-of-hospital cardiac arrest patient who received prolo...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2006.09.011
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:The current guidelines of the European Resuscitation Council (ERC) stipulate that an intraosseous access should be placed if establishing a peripheral venous access for cardiopulmonary resuscitation (CPR) would involve delays. The aim of this study was therefore to compare a manual intraosseous infusion te...
journal_title：Resuscitation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.resuscitation.2008.04.004
更新日期：2008-09-01 00:00:00
abstract：:We evaluated the ability of a previously derived outcome predictor to discriminate between ECG segments corresponding to return of spontaneous circulation (ROSC) or not in validation data from 136 patients with cardiac arrest. The new data used for validation were totally independent from the predictor derivation data...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2005.05.006
更新日期：2005-10-01 00:00:00
abstract：AIM:The aim of this study was to calculate the incidence of out-of-hospital cardiac arrest (OHCA) in primary health care in Greece and assess general practitioners' (GPs) willingness towards the use of automatic external defibrillator (AED). METHODS:We conducted a survey in GPs working in both private and public secto...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2011.04.010
更新日期：2011-09-01 00:00:00
abstract：IMPORTANCE:Assessment of morbidity is an important component of evaluating interventions for patients with out-of-hospital cardiac arrest (OHCA). OBJECTIVE:We evaluated among survivors of OHCA cognition, functional status, health-related quality of life and depression as functions of patient and emergency medical serv...
journal_title：Resuscitation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.resuscitation.2015.05.011
更新日期：2015-08-01 00:00:00
abstract：:To improve the outcome for out-of-hospital patients with ventricular fibrillation/pulseless ventricular tachycardia (VF/VT), the use of automated external defibrillators (AEDs) by first responders including non-medical personnel with a duty to respond to an emergency is recommended. A special CPR-AED course has been d...
journal_title：Resuscitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0300-9572(02)00351-9
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:A large proportion of cardiac arrests outside hospital are caused by ventricular fibrillation. Although it is frequently used, the exact role for treatment with lidocaine in these patients remains to be determined. AIM:To describe the proportion of patients with witnessed out-of-hospital cardiac arrest foun...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(96)01018-0
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVE:Gastric inflation (GI) is a significant issue when ventilation is performed on unprotected airways. DESIGN:Experimental analysis on the respiratory effects of hose extended bag-valve ventilation devices designed to reduce inspiratory pressure and flow. SETTING:Laboratory with lung/oesophageal sphincter simu...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2008.02.022
更新日期：2008-08-01 00:00:00
abstract：:Manikins currently used in newborn and paediatric resuscitation training are limited in their effectiveness by an inability to allow instructors control over airway patency. This means that attempts to introduce situations that require interventions, other than just appropriate head positioning to achieve successful l...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(02)00124-7
更新日期：2002-09-01 00:00:00
abstract：AIM:Increases in serum cytokines have been reported after successful resuscitation from prolonged ventricular fibrillation (VF). Pro-inflammatory cytokines can stimulate inducible nitric oxide synthase (iNOS) to produce excessive levels of nitric oxide (NO). High levels of both myocardial inflammatory cytokines and nit...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2008.01.026
更新日期：2008-06-01 00:00:00
abstract：AIMS:Out of Hospital Cardiac Arrest (OHCA) is frequently attributed to coronary artery disease, thus guidelines recommend coronary angiography (CAG) for survivors of OHCA. However, the real-world application of these guidelines is unknown, and we sought to evaluate CAG practices in the contemporary OHCA population. ME...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2018.10.007
更新日期：2018-12-01 00:00:00
abstract：:We evaluated the usefulness of a rapid, qualitative, bedside immunoassay for cardiac-specific troponin T in patients with chest pain. A concordant result between quantitative troponin T and qualitative troponin T assay was observed in 183 (96%) tests. The sensitivity of the rapid troponin T assay for detecting acute m...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(96)00969-0
更新日期：1996-10-01 00:00:00
abstract：:Pharmacological doses (40-160 micrograms/kg) of adrenocorticotropic hormone (ACTH) intravenously injected to urethane-anesthetized rats subjected to otherwise lethal hemorrhagic shock (mean arterial pressure stabilized at 20-25 mmHg) promptly restore blood pressure to about the pre-bleeding values, and prevent death (...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(89)90029-4
更新日期：1989-12-01 00:00:00
abstract：:Both checklists and recording manikin strips (strips) are used for evaluation of cardiopulmonary resuscitation (CPR) performance. To examine their relationship, we simultaneously evaluated single rescuer CPR of 255 subjects using both checklists and strips. For Group 1 (N = 192; general public tested in Heartsaver cou...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(90)90036-e
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:Comatose survivors of out-of-hospital cardiac arrest (OHCA) have high in-hospital mortality due to a complex pathophysiology that includes cardiovascular dysfunction, inflammation, coagulopathy, brain injury and persistence of the precipitating pathology. Therapeutic hypothermia (TH) is the only intervention...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2008.12.015
更新日期：2009-04-01 00:00:00
abstract：INTRODUCTION:Sudden cardiac death (SCD) survival decreases by 10% for each minute of delay in defibrillation, however, survival rates of 98% can be achieved when defibrillation is accomplished within 30s of collapse. Recently, a fully automated external cardioverter-defibrillator (AECD) was approved by the FDA for in-h...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2004.05.012
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Dispatcher-assisted cardiopulmonary resuscitation (DACPR) could improve the survival rate of out-of-hospital cardiac arrest (OHCA). However, the efficiency of DACPR varies. Our study compared the effectiveness of DACPR instructed via landline calls, mobile calls, and landline calls transferred to mobiles. M...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2019.11.008
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Demographic, social, economic and geographic factors are associated with increased short-term mortality after cardiac arrest. We sought to determine if these factors are additionally associated with long-term outcome differences using a detailed clinical database linked to state-wide administrative data. ME...
journal_title：Resuscitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.resuscitation.2018.04.032
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Within Europe and North America, the median annual mortality from snow avalanches between 1994 and 2003 was 141. There are two commonly used rescue devices: the avalanche transceiver, which is intended to speed up locating a completely buried person, and the avalanche airbag, which aims to prevent the person...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2007.06.002
更新日期：2007-12-01 00:00:00
abstract：:The International Liaison Committee on Resuscitation (ILCOR) publishes guidelines on neonatal resuscitation, which are evidence-based where possible. Initial assessment of heart rate, breathing and colour is an essential part of newborn resuscitation and the guidelines state that heart rate may be assessed using a ste...
journal_title：Resuscitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.resuscitation.2003.10.002
更新日期：2004-02-01 00:00:00
abstract：:Defibrillation is the definitive treatment for ventricular fibrillation (VF). Participation of physicians, paramedical personnel and lay people in cardiopulmonary resuscitation has significantly increased the survival from ventricular fibrillation. The number of defibrillators has increased and their primary placement...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(84)90037-6
更新日期：1984-02-01 00:00:00
