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Gabapentin: a novel drug as add-on therapy in cases of refractory overactive bladder in children.

Abstract：

OBJECTIVE:To determine the effectiveness of gabapentin as an add-on therapy in children presenting with overactive bladder (OAB) not responding to conventional anticholinergics. MATERIALS AND METHODS:Children with refractory OAB were included prospectively from March 2009 to February 2010. The inclusion criterion was persistence of symptoms while on conventional anticholinergics for 6 months. Gabapentin was prescribed as an add-on therapy. The patients were followed 4 weekly with bladder diary and urodynamic study was repeated at 3 months. RESULTS:There were 31 children, 26 of neurogenic OAB and 5 of non-neurogenic origin. Mean ± SD age was 8.5 ± 5.3 years. Data were analyzed in 30 patients as treatment was terminated in 1 due to adverse effects. Continence improved in 16 (53.3%) patients. Voiding volume improved from 175 ± 90 to 320 ± 110 ml (p<0.03). Objective assessment of OAB symptom relief showed marked improvement (p<0.05). Mean maximum cystometric bladder capacity improved from 210 ± 94 to 360 ± 110 ml (p<0.02). The maximal detrusor contraction decreased from 75 ± 35 to 25 ± 15 cmH(2)O (p<0.02). Fourteen patients (46.7%) failed to respond to gabapentin therapy. These patients had baseline maximum cystometric bladder capacity <60% for age and maximum detrusor contractions >50 cm of water (p<0.03). CONCLUSIONS:Gabapentin gives moderate results in children with OAB refractory to conventional anticholinergics. In general, the drug is well tolerated with fewer adverse effects.

journal_name

J Pediatr Urol

journal_title

Journal of pediatric urology

authors

Ansari MS,Bharti A,Kumar R,Ranjan P,Srivastava A,Kapoor R

doi

10.1016/j.jpurol.2011.10.022

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

17-22

issue

1

eissn

1477-5131

issn

1873-4898

pii

S1477-5131(11)00274-9

journal_volume

9

pub_type

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