Pediatric urolithiasis in a non-endemic country: a single center experience from The Netherlands.

Abstract:

OBJECTIVE:To provide insight in causative factors of pediatric urolithiasis in The Netherlands, a non-endemic country. PATIENTS AND METHODS:Data from 71 children with urolithiasis and stone analyses between 1996 and 2010 in the Radboud University Nijmegen Medical Centre were studied retrospectively. Patients (48 boys, 23 girls, ratio 2.1:1) were aged 0.5-18.3 years (mean 8.8, SD 5.6). All stone analyses were performed with FTIR spectroscopy. RESULTS:Of the 49 patients with metabolic analysis, 78% showed one (n = 15) or more (n = 23) metabolic abnormalities. Forty-seven percent had hypercalciuria (n = 23), 31% had hyperoxaluria (n = 15), 29% hypocitraturia (n = 14), 10% hyperuricosuria (n = 5), 10% cystinuria (n = 5), and 6% had hypomagnesiuria (n = 3). Sixty-one percent of the stones were composed of calcium phosphate, calcium oxalate, or a combination of those. Twenty-six percent consisted of pure or mixed magnesium ammonium phosphate, 8.3% pure or mixed urate, and 8.3% cystine. CONCLUSION:Children with urolithiasis in The Netherlands show stone composition similar to other Western European countries. However, a high percentage of metabolic abnormalities (78%) was found, indicating the need for extensive evaluation of pediatric urolithiasis to find underlying causes and thereby prevent stone recurrences. A close collaboration between a pediatric nephrologist and urologist is mandatory for optimal surgical and medical treatment.

journal_name

J Pediatr Urol

authors

Rellum DM,Feitz WF,van Herwaarden AE,Schreuder MF

doi

10.1016/j.jpurol.2013.07.019

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

155-61

issue

1

eissn

1477-5131

issn

1873-4898

pii

S1477-5131(13)00206-4

journal_volume

10

pub_type

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