Abstract：
OBJECTIVE:To assess the effectiveness and safety of intradetrusor injections of botulinum toxin type A (BTA) used to treat neurogenic detrusor overactivity in children. PATIENTS AND METHODS:We retrospectively reviewed the records of seven children treated at least once (7/7: one injection; 4/7: two and three injections; 2/7: four injections; 1/7: five injections) with intradetrusor BTA injections in 2005-2008, for neurogenic detrusor overactivity with incontinence despite timed bladder catheterizations and anticholinergic agents. Clinical, urodynamic, and imaging study data at baseline were collected. Clinical efficacy criteria were the urinary tract infection (UTI) rate, continence, and need for anticholinergic agents. The following urodynamic data were assessed: maximum catheterized volume without leakage, reflex volume, maximum detrusor pressure, and bladder compliance. RESULTS:Seven children received 18 injections. Social continence was achieved from the first injection. No further recurrent lower UTIs occurred. Maximum catheterized volume and reflex volume increased, and maximum detrusor pressure decreased. Detrusor compliance became interpretable and increased. Grade II right vesicoureteral reflux, present at baseline in one patient, resolved after BTA therapy. UTIs were the only adverse effects. CONCLUSION:Injection with BTA proved effective and safe in the short term. This may be an alternative to surgery in children with neurogenic detrusor overactivity.
journal_name
J Pediatr Uroljournal_title
Journal of pediatric urologyauthors
Do Ngoc Thanh C,Audry G,Forin Vdoi
10.1016/j.jpurol.2009.06.001subject
Has Abstractpub_date
2009-12-01 00:00:00pages
430-6issue
6eissn
1477-5131issn
1873-4898pii
S1477-5131(09)00358-1journal_volume
5pub_type
杂志文章abstract：OBJECTIVE:To evaluate the impact of imaging modalities on the evaluation and prognosis of children with multicystic dysplastic kidney (MCDK) disease. PATIENTS AND METHODS:A retrospective analysis of all children with MCDK diagnosed from 2004 until 2012 was performed. The study included 63 patients for whom all postnat...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2014.03.004
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:To address the issue of sexual function and fertility in PUV patients. PATIENTS AND METHODS:Of 47 patients (age > 18 years) treated for PUV in infancy 28 were contactable. They were sent a standard questionnaire requesting details on voiding dysfunction symptoms, and experience of erection, orgasm and ejacul...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2011.11.006
更新日期：2013-02-01 00:00:00
abstract：:We report on a child with hypertension secondary to MCDK who underwent an elective retroperitoneoscopic nephrectomy and is normotensive on follow up. We looked at the pathological correlation with respect to the hypertension caused by a non-functioning kidney. ...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2011.03.019
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:Faecal incontinence secondary to myelomeningocele, Hirschsprung disease, and anorectal anomalies remains a significant and common problem. We aimed to report our 5-year experience with the Peristeen trans-anal irrigation system (TAIS) to manage such children. PATIENTS AND METHOD:This study was a combination ...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2013.08.006
更新日期：2014-04-01 00:00:00
abstract：INTRODUCTION:Acute scrotal pain (ASP) remains one of the most common male urologic emergencies in the pediatric age group. The most concerning outcome of testicular torsion (TT) is the need for orchiectomy, which has a negative impact on the child's development in general and on sexual development and psychology in par...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2020.09.011
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:Testicular torsion is one of the most common diagnoses involved in lawsuits in the pediatric patient. Missed diagnosis and diagnostic delays put patients at risk for testicular loss and have resulted in malpractice litigation. Using a national database, we sought to describe testicular torsion malpractice cas...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2016.03.008
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:The epidemiology and risk factors for paediatric urolithiasis (UL) in developed countries are evolving, with increasing rates of metabolic stone-formers. In the United Kingdom (UK), only a single London cohort has been studied in the past three decades. Regional disease patterns across the UK remain unknown....
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2020.03.009
更新日期：2020-06-01 00:00:00
abstract：INTRODUCTION:Cloacal exstrophy (CE) is the most severe manifestation of the epispadias-exstrophy spectrum. Previous studies have indicated an increased rate of renal anomalies in children with classic bladder exstrophy (CBE). Given the increased severity of the CE defect, it was hypothesized that there would be an even...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2016.04.008
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:To provide insight in causative factors of pediatric urolithiasis in The Netherlands, a non-endemic country. PATIENTS AND METHODS:Data from 71 children with urolithiasis and stone analyses between 1996 and 2010 in the Radboud University Nijmegen Medical Centre were studied retrospectively. Patients (48 boys,...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2013.07.019
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:To assess whether repairing hypospadias before or after 18 months affects psychological adjustment, health-related quality of life (HRQoL) and surgical outcome. PATIENTS AND METHODS:Seventy-seven boys aged 6-17 years were assigned to one of two groups, according to whether they had a hypospadias repair befor...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2008.12.008
更新日期：2009-10-01 00:00:00
abstract：PURPOSE:The aim of this study is to investigate in Turkish boys the emotional effects of hypospadias repair before and after the optimal age for repair. MATERIALS AND METHODS:Forty hypospadias patients treated in our department were included in this study. Group 1 consisted of 13 patients operated on at less than 30 m...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2004.12.003
更新日期：2005-04-01 00:00:00
abstract：INTRODUCTION:Patients with spina bifida and other spinal dysraphisms commonly suffer from fecal incontinence and constipation, which can be treated with antegrade continence enemas. Currently, information regarding outcomes and satisfaction in children who have Chait cecostomy tubes is lacking. The aim of our study was...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2017.04.008
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the correction of different degrees of penile torsion following a ladder step so that simpler steps are used whenever possible. This can avoid the morbidity and complications of complex procedures. PATIENTS AND METHODS:Cases of congenital and acquired penile torsion were repaired on a ladder step...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2014.05.009
更新日期：2014-12-01 00:00:00
abstract：:Anorectal impalement is an uncommon mode of injury in children, with only a few case reports in the pediatric literature. No report describes a clinical presentation with bladder stones in a child, as in our case. This case highlights the need to maintain a high index of suspicion in all cases of rectal impalement, an...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2011.09.001
更新日期：2012-02-01 00:00:00
abstract：INTRODUCTION:Postobstructive diuresis (POD) is a polyuric state in which large quantities of salt and water are eliminated after solving a urinary tract obstruction. These patients are at increased risk of severe dehydration, electrolytic disturbances, hypovolemic shock, and death. Ureteropelvic junction obstruction (U...
journal_title：Journal of pediatric urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jpurol.2018.01.017
更新日期：2018-06-01 00:00:00
abstract：INTRODUCTION:Testicular microlithiasis (TM) is a condition characterized by calcium deposits within the testis, usually detected incidentally during ultrasonography of the scrotum. TM has been associated with the presence of, and possibly the development of, testicular malignancy. Our aim was to document international ...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2017.12.007
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:To report a novel cause of nocturnal enuresis (NE) and highlight the literature giving insight into this novel mechanism. PATIENT:A 12-year-old morbidly obese female with 2-year history of nightly secondary monosymptomatic NE. RESULTS:On evaluation, a history of severe sleep disturbed breathing was elicited...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2009.08.009
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVES:Testicular hypertrophy has previously been evaluated as a predictor of monorchism. However, its implication in clinical practice is not well evaluated. The aim of the present study was to examine its value in planning the operative time. PATIENTS AND METHODS:Medical charts of prospectively recorded data of ...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2015.06.010
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:We report percutaneous nephrolithotomy for the management of stones in anomalous kidneys in children. MATERIALS & METHODS:We performed PCNL on 6 children (one with bilateral stones), 3 boys and 3 girls with anomalous kidneys. Three had horseshoe kidneys, 2 malrotated kidneys, and one crossed fused ectopic kidn...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2011.02.025
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Preputioplasty as a part of hypospadias repair restores the normal appearance of phallus, which is especially important in distal and mid penile hypospadias. However possibility of its inherent complications such as iatrogenic phimosis or preputial breakdown are the cause of controversy and reluctance regard...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2020.04.014
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:The literature on small intestinal submucosa for chordee correction in children is scarce. We reviewed our experience with 1 ply SIS for ventral corporal body grafting in cases of severe ventral penile curvature associated with proximal hypospadias in children. MATERIALS AND METHODS:From 04-2001 to 12-2007, 58...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2011.03.008
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION:Patients with gonadal dysgenesis (GD) with a Y chromosome have an increased risk of gonadal neoplasm. Few data exist on the ability of imaging to detect malignancy in intra-abdominal gonads in these patients. OBJECTIVE:We aimed to determine the correlation between preoperative imaging findings and gonadal...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2017.11.009
更新日期：2018-04-01 00:00:00
abstract：:Eosinophilic cystitis is an inflammatory condition characterized by eosinophilic infiltration of whole layers of the bladder wall. The condition occurs more commonly in adults. We report a case of eosinophilic cystitis mimicking a bladder tumor in a 5-year-old boy with symptoms of dysuria and urinary incontinence. The...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2012.04.005
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Hypospadias is one of the most common congenital anomalies in childhood. The aim of this study is to apply elastosonography on normal and hypospadic penis to verify the structural differences in tissues composition and stiffness. MATERIALS AND METHODS:We analyzed medical chart of patients treated at our Ins...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2016.02.007
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Little has been reported to date on the instillation of antimicrobials directly into the bladder in children. Children with complex urinary tract anomalies struggle frequently with recurrent urinary tract infections (UTI), with frequent emergence of antibiotic resistance. Gentamicin bladder instillation to t...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2020.08.007
更新日期：2020-08-19 00:00:00
abstract：INTRODUCTION:In 2006, nomenclature referencing atypical sex development (i.e., 'intersex') was updated, and the term disorder of sex development (DSD) was formally introduced. Clinicians, patients, and parents, however, have not universally accepted the new terminology, and some continue to use different nomenclature. ...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2018.08.009
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Most children with symptoms of urolithiasis and urinary solute excretion abnormalities leading to stone formation have no calculi revealed by ultrasound or X-ray plain film ("occult urolithiasis"). This covers a large group of children presenting with common symptoms such as abdominal pain, hematuria, and dy...
journal_title：Journal of pediatric urology
pub_type： 杂志文章,评审
doi：10.1016/j.jpurol.2016.12.021
更新日期：2017-04-01 00:00:00
abstract：INTRODUCTION:Surgical treatment of pediatric kidney stones has changed dramatically in recent years because of the miniaturization of surgical instruments and the availability of intracorporeal lithotripters. The retrograde intrarenal surgery (RIRS) technique is nowadays considered an effective and safe procedure but s...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2017.09.011
更新日期：2018-02-01 00:00:00
abstract：:End-stage renal disease is becoming a contemporary global concern with increasing prevalence. The available treatment strategies are limited to dialysis and renal transplantation. However, limited organ supply and autoimmune rejection are the shortcomings that limit widespread application of transplantation. Favorably...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2018.01.008
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Post-ablation urethral strictures are a rare but devastating complication following transurethral ablation of posterior urethral valve which can be more difficult to treat than the valve itself. Though with the miniaturization of scopes the incidence of these strictures has decreased, sadly they still contin...
journal_title：Journal of pediatric urology
pub_type： 杂志文章
doi：10.1016/j.jpurol.2020.09.001
更新日期：2020-12-01 00:00:00
