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Epithelial growth factor and decompressive testicular fasciotomy to control ischemia reperfusion injury in rats.

Abstract：

PURPOSE:Testicular torsion is an urological emergency and an important cause of male infertility. Recent studies have shown that not only ischemia, but also the restoration of blood flow creates a deleterious situation for the testis. The goal of this work was to evaluate the role of systemic epithelial growth factor application and its association with decompressive fasciotomy in tissue recovery of the testes undergoing the torsion of the spermatic cord. METHOD:Torsion of the spermatic cord was induced in 40 Wistar pubescent testes for a period of 4 h. At the time of detorsion systemic epithelial growth factor and decompressive fasciotomy were applied as treatment alternatives. After 21 days, the testicles were examined macro and microscopically. RESULTS:The variables evaluated were weight, testicular volume and the degree of histological alterations by optical microscopy. The rate of healing of testicular torsion showed significant difference between the groups. It was noted that in terms of testicular weight and volume the animals treated with systemic epithelial growth factor resembled the control group and had a better histological classification than the other groups. The mean Johnsen score was significantly higher in the group treated with systemic growth factor and decompressive testicular fasciotomy than in the group without fasciotomy. No significant changes were noted in the contralateral testes. CONCLUSION:Although decompressive testicular fasciotomy improved spermatogenesis, recovery was limited. Systemic epithelial growth factor administered in combination with decompressive testicular fasciotomy was more effective for spermatogenesis than fasciotomy alone. Administering epithelial growth factor after reperfusion might have the potential to decrease long-term histologic damage after testicular torsion. The combination of decompressive testicular fasciotomy and epithelial growth factor had a synergistic effect on the healing of these testes.

journal_name

J Pediatr Urol

journal_title

Journal of pediatric urology

authors

Quintaes IPP,de Avelar GF,Quintaes AP,Boasquevisque PCR,Resende V

doi

10.1016/j.jpurol.2020.02.018

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

374.e1-374.e7

issue

3

eissn

1477-5131

issn

1873-4898

pii

S1477-5131(20)30052-8

journal_volume

16

pub_type

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