当前位置： SCI文献检索 > NEUROIMAGE期刊下所有文献 > Relationship between aberrant brain connectivity and clinical features in Angelman Syndrome: a new method using tract based spatial statistics of DTI color-coded orientation maps.

Relationship between aberrant brain connectivity and clinical features in Angelman Syndrome: a new method using tract based spatial statistics of DTI color-coded orientation maps.

Abstract：

AIM:In order to relate brain structural abnormalities to clinical features of Angelman Syndrome (AS), we determined the locations of abnormal regional white matter architecture in AS children using a sensitive and objective whole brain approach to analyze diffusion tensor imaging (DTI) color-coded orientation maps. METHODS:Using tract based spatial statistics (TBSS) of DTI color-coded orientation maps, the fraction of fibers oriented in the anteroposterior (AP), mediolateral (ML) and superioinferior (SI) directions were determined in whole brain white matter of 7 children with AS (mean age: 70±25.78 months, 5 males) and 7 children with typical development (TD, mean age: 79.8±17.25 months, 4 males). TBSS of FA map was also performed for comparison. RESULTS:Children with AS had a significantly lower AP component than the TD group in 9 clusters (3 bilateral and 3 unilateral). Bilateral clusters were located in inferior fronto-occipital fasciculus, anterior thalamic radiation and arcuate fasciculus regions. Unilateral clusters involved left brainstem, left cingulum and right uncinate regions. Similarly, children with AS had significantly lower ML component than the TD group in 4 clusters (2 in corpus callosum and 2 unilateral clusters). Unilateral clusters were located in the left cingulum and left anterior thalamic radiation regions. SI component was lower in children with AS in two clusters compared to TD (corticospinal tract and corpus callosum). FA map clusters mostly corresponded with component clusters. INTERPRETATION:Children with AS have a global impairment of white matter integrity including AP, ML and SI components in whole brain suggesting a potential underlying error with axon guidance mechanisms during brain development possibly due to loss of UBE3A gene expression. Some of this aberrant connectivity can be related to the clinical features of AS.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Tiwari VN,Jeong JW,Wilson BJ,Behen ME,Chugani HT,Sundaram SK

doi

10.1016/j.neuroimage.2011.07.067

subject

Has Abstract

pub_date

2012-01-02 00:00:00

pages

349-55

issue

1

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(11)00862-7

journal_volume

59

pub_type

杂志文章

相关文献

NEUROIMAGE文献大全
  • Prestimulus alpha power predicts fidelity of sensory encoding in perceptual decision making.

    abstract：:Pre-stimulus α power has been shown to correlate with the behavioral accuracy of perceptual decisions. In most cases, these correlations have been observed by comparing α power for different behavioral outcomes (e.g. correct vs incorrect trials). In this paper we investigate such covariation within the context of beha...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.10.041

    authors： Lou B,Li Y,Philiastides MG,Sajda P

    更新日期：2014-02-15 00:00:00

  • T2 quantification from only proton density and T2-weighted MRI by modelling actual refocusing angles.

    abstract：:Proton density and transverse relaxation (T2)-weighted fast spin echo images are frequently acquired. T2 quantification is commonly performed by applying an exponential fit to these two images, despite recent evidence that an exponential fit is insufficient to correctly quantify T2 in the presence of imperfect RF refo...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.05.079

    authors： McPhee KC,Wilman AH

    更新日期：2015-09-01 00:00:00

  • Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease.

    abstract：OBJECTIVE:Our primary objective was to compare the performance of unaccelerated vs. accelerated structural MRI for measuring disease progression using serial scans in Alzheimer's disease (AD). METHODS:We identified cognitively normal (CN), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI) a...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.03.026

    authors： Vemuri P,Senjem ML,Gunter JL,Lundt ES,Tosakulwong N,Weigand SD,Borowski BJ,Bernstein MA,Zuk SM,Lowe VJ,Knopman DS,Petersen RC,Fox NC,Thompson PM,Weiner MW,Jack CR Jr,Alzheimer's Disease Neuroimaging Initiative.

    更新日期：2015-06-01 00:00:00

  • Neural correlates of enhanced response inhibition in the aftermath of stress.

    abstract：:Life stress has been shown to impact cognitive functions, including inhibitory control. However, the immediate effects of acute stress on inhibitory control and the underlying neural mechanisms remain unclear. In a behavioral pilot study (N = 30) and a within-subject functional magnetic resonance imaging study (N = 30...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2019.116212

    authors： Chang J,Hu J,Li CR,Yu R

    更新日期：2020-01-01 00:00:00

  • The differential effect of trigeminal vs. peripheral pain stimulation on visual processing and memory encoding is influenced by pain-related fear.

    abstract：:Compared to peripheral pain, trigeminal pain elicits higher levels of fear, which is assumed to enhance the interruptive effects of pain on concomitant cognitive processes. In this fMRI study we examined the behavioral and neural effects of trigeminal (forehead) and peripheral (hand) pain on visual processing and memo...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.03.026

    authors： Schmidt K,Forkmann K,Sinke C,Gratz M,Bitz A,Bingel U

    更新日期：2016-07-01 00:00:00

  • Sex matters: Neural correlates of voice gender perception.

    abstract：:The basis for different neural activations in response to male and female voices as well as the question, whether men and women perceive male and female voices differently, has not been thoroughly investigated. Therefore, the aim of the present study was to examine the behavioral and neural correlates of gender-relate...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.04.105

    authors： Junger J,Pauly K,Bröhr S,Birkholz P,Neuschaefer-Rube C,Kohler C,Schneider F,Derntl B,Habel U

    更新日期：2013-10-01 00:00:00

  • Audio-visual speech processing in age-related hearing loss: Stronger integration and increased frontal lobe recruitment.

    abstract：:Hearing loss is associated with difficulties in understanding speech, especially under adverse listening conditions. In these situations, seeing the speaker improves speech intelligibility in hearing-impaired participants. On the neuronal level, previous research has shown cross-modal plastic reorganization in the aud...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.04.023

    authors： Rosemann S,Thiel CM

    更新日期：2018-07-15 00:00:00

  • Separate neural systems for processing action- or non-action-related sounds.

    abstract：:The finding of a multisensory representation of actions in a premotor area of the monkey brain suggests that similar multimodal action-matching mechanisms may also be present in humans. Based on the existence of an audiovisual mirror system, we investigated whether sounds referring to actions that can be performed by ...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.neuroimage.2004.09.025

    authors： Pizzamiglio L,Aprile T,Spitoni G,Pitzalis S,Bates E,D'Amico S,Di Russo F

    更新日期：2005-02-01 00:00:00

  • Transferring and generalizing deep-learning-based neural encoding models across subjects.

    abstract：:Recent studies have shown the value of using deep learning models for mapping and characterizing how the brain represents and organizes information for natural vision. However, modeling the relationship between deep learning models and the brain (or encoding models), requires measuring cortical responses to large and ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.04.053

    authors： Wen H,Shi J,Chen W,Liu Z

    更新日期：2018-08-01 00:00:00

  • Neural bases of asymmetric language switching in second-language learners: an ER-fMRI study.

    abstract：:Using the ER-fMRI technique, the present study was designed to investigate the neural substrates of language switching among second-language learners. Twelve Chinese college students who were learning English were scanned when they performed language switching tasks (naming pictures in their first [L1, Chinese] and se...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.09.054

    authors： Wang Y,Xue G,Chen C,Xue F,Dong Q

    更新日期：2007-04-01 00:00:00

  • A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability.

    abstract：:There has been growing interest in the role of postnatal brain development in the etiology of several neurologic diseases. The rat has long been recognized as a powerful model system for studying neuropathology and the safety of pharmacologic treatments. However, the complex spatiotemporal changes that occur during ra...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.01.017

    authors： Calabrese E,Badea A,Watson C,Johnson GA

    更新日期：2013-05-01 00:00:00

  • Bilateral spatial filtering: refining methods for localizing brain activation in the presence of parenchymal abnormalities.

    abstract：:Functional MRI (fMRI) is an important tool for pre-surgical localization of eloquent cortex prior to resection of brain lesions. To increase the inherently low activation signal to noise ratio, fMRI pre-processing steps often include spatial smoothing. However, the effects of smoothing in the presence of brain lesions...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.06.051

    authors： Walker SA,Miller D,Tanabe J

    更新日期：2006-11-01 00:00:00

  • Spontaneous cognition and its relationship to human creativity: A functional connectivity study involving a chain free association task.

    abstract：:Resting-state functional connectivity (RSFC) between various brain regions is thought to be associated with creative abilities. Extensive research correlating RSFC with performance on creativity tasks has revealed some of the RSFC patterns characterizing 'the creative brain'. Yet, our understanding of the neurocogniti...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2020.117064

    authors： Marron TR,Berant E,Axelrod V,Faust M

    更新日期：2020-10-15 00:00:00

  • White matter alterations to cingulum and fornix following very preterm birth and their relationship with cognitive functions.

    abstract：:Very preterm birth (VPT; <32 weeks of gestation) has been associated with impairments in memory abilities and functional neuroanatomical brain alterations in medial temporal and fronto-parietal areas. Here we investigated the relationship between structural connectivity in memory-related tracts and various aspects of ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.02.026

    authors： Caldinelli C,Froudist-Walsh S,Karolis V,Tseng CE,Allin MP,Walshe M,Cuddy M,Murray RM,Nosarti C

    更新日期：2017-04-15 00:00:00

  • A spatio-temporal nonparametric Bayesian variable selection model of fMRI data for clustering correlated time courses.

    abstract：:In this paper we present a novel wavelet-based Bayesian nonparametric regression model for the analysis of functional magnetic resonance imaging (fMRI) data. Our goal is to provide a joint analytical framework that allows to detect regions of the brain which exhibit neuronal activity in response to a stimulus and, sim...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2014.03.024

    authors： Zhang L,Guindani M,Versace F,Vannucci M

    更新日期：2014-07-15 00:00:00

  • Different patterns of cortical activity in females and males during spatial long-term memory.

    abstract：:It is generally assumed that identical neural regions mediate the same cognitive functions in females and males. However, anatomic and molecular sex differences exist in the brain, including in regions associated with long-term memory, which suggests there may be functional differences. The present functional magnetic...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2019.06.027

    authors： Spets DS,Jeye BM,Slotnick SD

    更新日期：2019-10-01 00:00:00

  • Brain default-mode network dysfunction in addiction.

    abstract：:Aberrant patterns of brain functional connectivity in the default mode network (DMN) have been observed across different classes of substance use disorder (SUD) and are associated with craving and relapse. In addicted individuals resting functional connectivity (RSFC) of the anterior DMN, which participates in attribu...

    journal_title：NeuroImage

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroimage.2019.06.036

    authors： Zhang R,Volkow ND

    更新日期：2019-10-15 00:00:00

  • In vivo tracing of major rat brain pathways using manganese-enhanced magnetic resonance imaging and three-dimensional digital atlasing.

    abstract：:The magnetic resonance imaging (MRI)-detectable T1 contrast agent manganese (Mn2+) has recently been introduced as a neural tracer in rodents, birds, and monkeys. We have tested to what extent this in vivo method is useful for three-dimensional (3-D) survey of connectivity patterns in the rat somatosensory system. A c...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2003.07.009

    authors： Leergaard TB,Bjaalie JG,Devor A,Wald LL,Dale AM

    更新日期：2003-11-01 00:00:00

  • Right rolandic activation during speech perception in stutterers: a MEG study.

    abstract：:The focus of our magnetoencephalographic (MEG) study was to obtain further insight into the neuronal organization of language processing in stutterers. We recorded neuronal activity of 10 male developmental stutterers and 10 male controls, while they listened to pure tones, to words in order to repeat them, and to sen...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2004.11.024

    authors： Biermann-Ruben K,Salmelin R,Schnitzler A

    更新日期：2005-04-15 00:00:00

  • DTI of commissural fibers in patients with Chiari II-malformation.

    abstract：:Chiari II-malformation is a complex congenital deformity of the brain which is frequently associated with hydrocephalus. Abnormalities of the corpus callosum are known to occur in the majority of patients. The objective of the present study was to study the microstructure of the corpus callosum (CC) and the anterior c...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2008.09.006

    authors： Herweh C,Akbar M,Wengenroth M,Blatow M,Mair-Walther J,Rehbein N,Nennig E,Schenk JP,Heiland S,Stippich C

    更新日期：2009-01-15 00:00:00

  • ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.

    abstract：:ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared to patient non-carriers, we investigated whether ZNF804A was also associated with variation in ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.09.089

    authors： Donohoe G,Rose E,Frodl T,Morris D,Spoletini I,Adriano F,Bernardini S,Caltagirone C,Bossù P,Gill M,Corvin AP,Spalletta G

    更新日期：2011-02-01 00:00:00

  • Identification of large-scale networks in the brain using fMRI.

    abstract：:Cognition is thought to result from interactions within large-scale networks of brain regions. Here, we propose a method to identify these large-scale networks using functional magnetic resonance imaging (fMRI). Regions belonging to such networks are defined as sets of strongly interacting regions, each of which showi...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2005.08.044

    authors： Bellec P,Perlbarg V,Jbabdi S,Pélégrini-Issac M,Anton JL,Doyon J,Benali H

    更新日期：2006-02-15 00:00:00

  • Evaluation of ICA-AROMA and alternative strategies for motion artifact removal in resting state fMRI.

    abstract：:We proposed ICA-AROMA as a strategy for the removal of motion-related artifacts from fMRI data (Pruim et al., 2015). ICA-AROMA automatically identifies and subsequently removes data-driven derived components that represent motion-related artifacts. Here we present an extensive evaluation of ICA-AROMA by comparing our ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.02.063

    authors： Pruim RHR,Mennes M,Buitelaar JK,Beckmann CF

    更新日期：2015-05-15 00:00:00

  • Visual cortex signals a mismatch between regularity of auditory and visual streams.

    abstract：:Understanding how humans code for and respond to environmental uncertainty/regularity is a question shared by current computational and neurobiological approaches to human cognition. To date, studies investigating neurobiological systems that track input uncertainty have examined responses to uni-sensory streams. It i...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.05.028

    authors： Andric M,Davis B,Hasson U

    更新日期：2017-08-15 00:00:00

  • The past tense debate: is phonological complexity the key to the puzzle?

    abstract：:Theorists disagree over whether our language faculty is a single system or a dual one. Those supporting the latter position believe that English regular and irregular past tense verbs reflect this duality, with some proposing that each is processed by a rule mechanism and memorised lexicon respectively. Single system ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.04.008

    authors： Oh TM,Tan KL,Ng P,Berne YI,Graham S

    更新日期：2011-07-01 00:00:00

  • Multi-atlas based segmentation of brain images: atlas selection and its effect on accuracy.

    abstract：:Quantitative research in neuroimaging often relies on anatomical segmentation of human brain MR images. Recent multi-atlas based approaches provide highly accurate structural segmentations of the brain by propagating manual delineations from multiple atlases in a database to a query subject and combining them. The atl...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.02.018

    authors： Aljabar P,Heckemann RA,Hammers A,Hajnal JV,Rueckert D

    更新日期：2009-07-01 00:00:00

  • Bottom up modeling of the connectome: linking structure and function in the resting brain and their changes in aging.

    abstract：:With the increasing availability of advanced imaging technologies, we are entering a new era of neuroscience. Detailed descriptions of the complex brain network enable us to map out a structural connectome, characterize it with graph theoretical methods, and compare it to the functional networks with increasing detail...

    journal_title：NeuroImage

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroimage.2013.04.055

    authors： Nakagawa TT,Jirsa VK,Spiegler A,McIntosh AR,Deco G

    更新日期：2013-10-15 00:00:00

  • Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression.

    abstract：:Human depression, for which chronic psychosocial stress is a major risk factor, is characterized by consistent alterations in neurocircuitry. For example, there is increased functional connectivity (FC) within and between regions comprising the default mode network (DMN) including prefrontal cortex and cingulate corte...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.08.013

    authors： Grandjean J,Azzinnari D,Seuwen A,Sigrist H,Seifritz E,Pryce CR,Rudin M

    更新日期：2016-11-15 00:00:00

  • Ageing shows a pattern of cerebellar degeneration analogous, but not equal, to that in patients suffering from cerebellar degenerative disease.

    abstract：:Ageing generally leads to impairments in cognitive function and the ability to execute and learn new movements. While the causes of these impairments are often multi-factorial, integrity of the cerebellum in an elderly population is an important predictive factor of both motor function and cognitive function. A simila...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.03.084

    authors： Hulst T,van der Geest JN,Thürling M,Goericke S,Frens MA,Timmann D,Donchin O

    更新日期：2015-08-01 00:00:00

  • MSM: a new flexible framework for Multimodal Surface Matching.

    abstract：:Surface-based cortical registration methods that are driven by geometrical features, such as folding, provide sub-optimal alignment of many functional areas due to variable correlation between cortical folding patterns and function. This has led to the proposal of new registration methods using features derived from f...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2014.05.069

    authors： Robinson EC,Jbabdi S,Glasser MF,Andersson J,Burgess GC,Harms MP,Smith SM,Van Essen DC,Jenkinson M

    更新日期：2014-10-15 00:00:00