Mechanisms and management of doxorubicin cardiotoxicity.

Abstract:

:Doxorubicin is an effective anti-tumor agent with a cumulative dose-dependent cardiotoxicity. In addition to its principal toxic mechanisms involving iron and redox reactions, recent studies have described new mechanisms of doxorubicin-induced cell death, including abnormal protein processing, hyper-activated innate immune responses, inhibition of neuregulin-1 (NRG1)/ErbB(HER) signalling, impaired progenitor cell renewal/cardiac repair, and decreased vasculogenesis. Although multiple mechanisms involved in doxorubicin cardiotoxicity have been studied, there is presently no clinically proven treatment established for doxorubicin cardiomyopathy. Iron chelator dexrazoxane, angiotensin converting enzyme (ACE) inhibitors, and β-blockade have been proposed as potential preventive strategies for doxorubicin cardiotoxicity. Novel approaches such as anti-miR-146 or recombinant NRG1 to increase cardiomyocyte resistance to toxicity may be of interest in the future.

journal_name

Herz

journal_title

Herz

authors

Shi Y,Moon M,Dawood S,McManus B,Liu PP

doi

10.1007/s00059-011-3470-3

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

296-305

issue

4

eissn

0340-9937

issn

1615-6692

journal_volume

36

pub_type

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