Systemic bone marrow disorders: characterization with proton chemical shift imaging.

Abstract:

:In a prospective clinical study, 26 patients (22 with malignant lymphoma and 4 with myelofibrosis) and 9 healthy volunteers were examined by conventional magnetic resonance and proton chemical shift imaging (CSI; modified Dixon method). On the basis of the CSI data, a quantitative evaluation of the relative fat and water signal fractions in regions of interest of the femur, pelvis, and spine was performed. In 16 of 17 patients with biopsy-proven bone marrow disorders, CSI revealed a significant reduction in the fat fraction of the bone marrow relative to that of normal volunteers. The visual assessment could detect only 14 of the 17 pathological cases.

journal_name

J Comput Assist Tomogr

authors

Gückel F,Brix G,Semmler W,Zuna I,Knauf W,Ho AD,van Kaick G

doi

10.1097/00004728-199007000-00023

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

633-42

issue

4

eissn

0363-8715

issn

1532-3145

journal_volume

14

pub_type

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