Abstract:
:Vomeronasal sensitivity is important for detecting intraspecific pheromonal cues as well as environmental odorants and is involved in mating, social interaction, and other daily activities of many vertebrates. Two large families of seven-transmembrane G-protein-coupled receptors, V1rs and V2rs, bind to various ligands to initiate vomeronasal signal transduction. Although the macroevolution of V1r and V2r genes has been well characterized throughout vertebrates, especially mammals, little is known about their microevolutionary patterns, which hampers a clear understanding of the evolutionary forces behind the rapid evolutionary turnover of V1r and V2r genes and the great diversity in receptor repertoire across species. Furthermore, the role of divergent vomeronasal perception in enhancing premating isolation and maintaining species identity has not been evaluated. Here we sequenced 44 V1r genes and 25 presumably neutral noncoding regions in 14 wild-caught mice belonging to Mus musculus and M. domesticus, two closely related species with strong yet incomplete reproductive isolation. We found that nucleotide changes in V1rs are generally under weak purifying selection and that only ∼5% of V1rs may have been subject to positive selection that promotes nonsynonymous substitutions. Consistent with the low functional constraints on V1rs, 18 of the 44 V1rs have null alleles segregating in one or both species. Together, our results demonstrate that, despite occasional actions of positive selection, the evolution of V1rs is in a large part shaped by purifying selection and random drift. These findings have broad implications for understanding the driving forces of rapid gene turnovers that are often observed in the evolution of large gene families.
journal_name
Genome Biol Evoljournal_title
Genome biology and evolutionauthors
Park SH,Podlaha O,Grus WE,Zhang Jdoi
10.1093/gbe/evr039subject
Has Abstractpub_date
2011-01-01 00:00:00pages
401-12issn
1759-6653pii
evr039journal_volume
3pub_type
杂志文章abstract::Sex chromosomes contribute substantially to key evolutionary processes such as speciation and adaptation. Several theories suggest that evolution could occur more rapidly on sex chromosomes, but currently our understanding of whether and how this occurs is limited. Here, we present an analysis of the great tit (Parus ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa044
更新日期:2020-03-01 00:00:00
abstract::Primary metabolism is essential to plants for growth and development, and secondary metabolism helps plants to interact with the environment. Many plant metabolites are industrially important. These metabolites are produced by plants through complex metabolic pathways. Lack of knowledge about these pathways is hinderi...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv217
更新日期:2015-11-10 00:00:00
abstract::Several taxonomically distinct mammalian groups-certain microbats and cetaceans (e.g., dolphins)-share both morphological adaptations related to echolocation behavior and strong signatures of convergent evolution at the amino acid level across seven genes related to auditory processing. Aye-ayes (Daubentonia madagasca...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evx140
更新日期:2017-07-01 00:00:00
abstract::It is well known that horizontal gene transfer (HGT) is a major force in the evolution of prokaryotes. During the adaptation of a bacterial population to a new ecological niche, and particularly for intracellular bacteria, selective pressures are shifted and ecological niches reduced, resulting in a lower rate of gene...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evt178
更新日期:2013-01-01 00:00:00
abstract::Hemerythrins and hemocyanins are respiratory proteins present in some of the most ecologically diverse animal lineages; however, the precise evolutionary history of their enzymatic domains (hemerythrin, hemocyanin M, and tyrosinase) is still not well understood. We survey a wide dataset of prokaryote and eukaryote gen...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evt102
更新日期:2013-01-01 00:00:00
abstract::Great genetic variability among teleost immunomes, with gene losses and expansions of central adaptive and innate components, has been discovered through genome sequencing over the last few years. Here, we demonstrate that the innate Myxovirus resistance gene (Mx) is lost from the ancestor of Gadiformes and the closel...
journal_title:Genome biology and evolution
pub_type: 信件
doi:10.1093/gbe/evw250
更新日期:2016-12-31 00:00:00
abstract::Each animal microRNA (miRNA) targets many genes for repression. Down-regulation of most of these targets is weak and has no detectable individual phenotypic effect. Whether this extensive weak repression is biologically relevant is a central issue in the debate on miRNA functionality. In the "small (target) pool" view...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evy079
更新日期:2018-04-01 00:00:00
abstract::The genus Claviceps has been known for centuries as an economically important fungal genera for pharmacology and agricultural research. Only recently have researchers begun to unravel the evolutionary history of the genus, with origins in South America and classification of four distinct sections through ecological, m...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa267
更新日期:2021-01-29 00:00:00
abstract::The chloroplast is an essential plant organelle responsible for photosynthesis. Gene duplication, relocation, and loss in the chloroplast genome (cpDNA) are useful for exploring the evolution and phylogeny of plant species. In this study, the complete chloroplast genome of Paris verticillata was sequenced using the 45...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu138
更新日期:2014-06-19 00:00:00
abstract::Conservation of function can be accompanied by obvious similarity of homologous sequences which may persist for billions of years (Iyer LM, Leipe DD, Koonin EV, Aravind L. 2004. Evolutionary history and higher order classification of AAA+ ATPases. J Struct Biol. 146:11-31.). However, presumably homologous segments of ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evt023
更新日期:2013-01-01 00:00:00
abstract::Different genes and proteins evolve at very different rates. To identify the factors that explain these differences is an important aspect of research in molecular evolution. One such factor is the role a protein plays in a large molecular network. Here, we analyze the evolutionary rates of enzyme-coding genes in the ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evy234
更新日期:2018-11-01 00:00:00
abstract::Because of its highly repetitive nature, the human male-specific Y chromosome remains understudied. It is important to investigate variation on the Y chromosome to understand its evolution and contribution to phenotypic variation, including infertility. Approximately 20% of the human Y chromosome consists of ampliconi...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evy086
更新日期:2018-05-01 00:00:00
abstract::The mechanistic basis of regulatory variation and the prevailing evolutionary forces shaping that variation are known to differ between sexes and between chromosomes. Regulatory variation of gene expression can be due to functional changes within a gene itself (cis) or in other genes elsewhere in the genome (trans). T...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu060
更新日期:2014-04-01 00:00:00
abstract::In general, proteins do not work alone; they form macromolecular complexes to play fundamental roles in diverse cellular functions. On the basis of their iterative clustering procedure and frequency of occurrence in the macromolecular complexes, the protein subunits have been categorized as core and attachment. Core p...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evt096
更新日期:2013-01-01 00:00:00
abstract::Parasitoid wasps are among the most speciose animals, yet have relatively few available genomic resources. We report a draft genome assembly of the wasp Diachasma alloeum (Hymenoptera: Braconidae), a host-specific parasitoid of the apple maggot fly Rhagoletis pomonella (Diptera: Tephritidae), and a developing model fo...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz205
更新日期:2019-10-01 00:00:00
abstract::Genomic structural variants (SVs) are distributed nonrandomly across the human genome. The "hotspots" of SVs have been implicated in evolutionary innovations, as well as medical conditions. However, the evolutionary and biomedical features of these hotspots remain incompletely understood. Here, we analyzed data from 2...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz058
更新日期:2019-04-01 00:00:00
abstract::The major human pathogens Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major are collectively known as the Tritryps. The initial comparative analysis of their genomes has uncovered that Tritryps share a great number of genes, but repetitive DNA seems to be extremely variable between them. However, the in-dept...
journal_title:Genome biology and evolution
pub_type: 信件
doi:10.1093/gbe/evz017
更新日期:2019-02-01 00:00:00
abstract::Clashes between transcription and replication complexes can cause point mutations and chromosome rearrangements on heavily transcribed genes. In eukaryotic ribosomal RNA genes, the system that prevents transcription-replication conflicts also causes frequent copy number variation. Such fast mutational dynamics do not ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evz235
更新日期:2019-11-01 00:00:00
abstract::Protein metabolism is one of the most costly processes in the cell and is therefore expected to be under the effective control of natural selection. We stimulated yeast strains to overexpress each single gene product to approximately 1% of the total protein content. Consistent with previous reports, we found that exce...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evt154
更新日期:2013-01-01 00:00:00
abstract::Klebsiella pneumoniae clonal group (CG) 258, comprising sequence types (STs) 258, 11, and closely related variants, is associated with dissemination of the K. pneumoniae carbapenemase (KPC). Hospital outbreaks of KPC CG258 infections have been observed globally and are very difficult to treat. As a consequence, there ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evv062
更新日期:2015-04-10 00:00:00
abstract::Only few studies on snake venoms were dedicated to deeply characterize the toxin secretion of animals from the Colubridae family, despite the fact that they represent the majority of snake diversity. As a consequence, some evolutionary trends observed in venom proteins that underpinned the evolutionary histories of sn...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw149
更新日期:2016-08-16 00:00:00
abstract::Corals belong to the most basal class of the Phylum Cnidaria, which is considered the sister group of bilaterian animals, and thus have become an emerging model to study the evolution of developmental mechanisms. Although cell renewal, differentiation, and maintenance of pluripotency are cellular events shared by mult...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw042
更新日期:2016-03-23 00:00:00
abstract::Organisms show striking differences in genome structure; however, the functional implications and fundamental forces that govern these differences remain obscure. The intron-exon organization of nuclear genes is involved in a particularly large variety of structures and functional roles. We performed a 22-species stud...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evr056
更新日期:2011-01-01 00:00:00
abstract::The Arabidopsis DA1 genes appear to have multiple functions in regulating organ size and abiotic stress response, but the biological roles of its closely related genes remain unknown. Evolutionary analyses might provide some clues to aid in an understanding of their functional diversification. In this work, we charact...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu076
更新日期:2014-04-01 00:00:00
abstract::Homologous recombination is a major driver of bacterial speciation. Genetic divergence and host association are important factors influencing homologous recombination. Here, we study these factors for Campylobacter fetus, which shows a distinct intraspecific host dichotomy. Campylobacter fetus subspecies fetus (Cff) a...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evy048
更新日期:2018-03-01 00:00:00
abstract::The genome of the bladderwort Utricularia gibba provides an unparalleled opportunity to uncover the adaptive landscape of an aquatic carnivorous plant with unique phenotypic features such as absence of roots, development of water-filled suction bladders, and a highly ramified branching pattern. Despite its tiny size, ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evu288
更新日期:2015-01-09 00:00:00
abstract::Protection against inflammation and oxidative stress is key in slowing down aging processes. The honey bee (Apis mellifera) shows flexible aging patterns linked to the social role of individual bees. One molecular factor associated with honey bee aging regulation is vitellogenin, a lipoglycophosphoprotein with anti-in...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evw014
更新日期:2016-03-09 00:00:00
abstract::The extent of genome divergence and the evolutionary events leading to speciation of marine bacteria have mostly been studied for (locally) abundant, free-living groups. The genus Phaeobacter is found on different marine surfaces, seems to occupy geographically disjunct habitats, and is involved in different biotic in...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evx249
更新日期:2017-12-01 00:00:00
abstract::Retrotransposons, DNA sequences capable of creating copies of themselves, compose about half of the human genome and played a central role in the evolution of mammals. Their current position in the host genome is the result of the retrotranscription process and of the following host genome evolution. We apply a model ...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evaa201
更新日期:2020-11-03 00:00:00
abstract::The nearly neutral theory, which proposes that most mutations are deleterious or close to neutral, predicts that the ratio of nonsynonymous over synonymous substitution rates (dN/dS), and potentially also the ratio of radical over conservative amino acid replacement rates (Kr/Kc), are negatively correlated with effect...
journal_title:Genome biology and evolution
pub_type: 杂志文章
doi:10.1093/gbe/evt083
更新日期:2013-01-01 00:00:00