Abstract:
BACKGROUND:Species of the crenarchaeon Sulfolobus harbour three replication origins in their single circular chromosome that are synchronously initiated during replication. RESULTS:We demonstrate that global gene expression in two Sulfolobus species is highly biased, such that early replicating genome regions are more highly expressed at all three origins. The bias by far exceeds what would be anticipated by gene dosage effects alone. In addition, early replicating regions are denser in archaeal core genes (enriched in essential functions), display lower intergenic distances, and are devoid of mobile genetic elements. CONCLUSION:The strong replication-biased structuring of the Sulfolobus chromosome implies that the multiple replication origins serve purposes other than simply shortening the time required for replication. The higher-level chromosomal organisation could be of importance for minimizing the impact of DNA damage, and may also be linked to transcriptional regulation.
journal_name
BMC Genomicsjournal_title
BMC genomicsauthors
Andersson AF,Pelve EA,Lindeberg S,Lundgren M,Nilsson P,Bernander Rdoi
10.1186/1471-2164-11-454subject
Has Abstractpub_date
2010-07-28 00:00:00pages
454issn
1471-2164pii
1471-2164-11-454journal_volume
11pub_type
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