Abstract:
BACKGROUND:The genesis of the eukaryotes was a pivotal event in evolution and was accompanied by the acquisition of numerous new cellular features including compartmentalization by cytoplasmic organelles, mitosis and meiosis, and ciliary motility. Essential for the development of these features was the tubulin cytoskeleton and associated motors. It is therefore possible to map ancient cell evolution by reconstructing the evolutionary history of motor proteins. Here, we have used the kinesin motor repertoire of 45 extant eukaryotes to infer the ancestral state of this superfamily in the last common eukaryotic ancestor (LCEA). RESULTS:We bioinformatically identified 1624 putative kinesin proteins, determined their protein domain architectures and calculated a comprehensive Bayesian phylogeny for the kinesin superfamily with statistical support. These data enabled us to define 51 anciently-derived kinesin paralogs (including three new kinesin families) and 105 domain architectures. We then mapped these characters across eukaryotes, accounting for secondary loss within established eukaryotic groupings, and alternative tree topologies. CONCLUSIONS:We show that a minimum of 11 kinesin families and 3 protein domain architectures were present in the LCEA. This demonstrates that the microtubule-based cytoskeleton of the LCEA was surprisingly highly developed in terms of kinesin motor types, but that domain architectures have been extensively modified during the diversification of the eukaryotes. Our analysis provides molecular evidence for the existence of several key cellular functions in the LCEA, and shows that a large proportion of motor family diversity and cellular complexity had already arisen in this ancient cell.
journal_name
BMC Evol Bioljournal_title
BMC evolutionary biologyauthors
Wickstead B,Gull K,Richards TAdoi
10.1186/1471-2148-10-110subject
Has Abstractpub_date
2010-04-27 00:00:00pages
110issn
1471-2148pii
1471-2148-10-110journal_volume
10pub_type
杂志文章abstract:BACKGROUND:Hoplolaimina plant-parasitic nematodes (PPN) are a lineage of animals with many documented cases of horizontal gene transfer (HGT). In a recent study, we reported on three likely HGT candidate genes in the soybean cyst nematode Heterodera glycines, all of which encode secreted candidate effectors with putati...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-016-0651-y
更新日期:2016-04-12 00:00:00
abstract:BACKGROUND:Lepidosauria (lizards, snakes, tuatara) is a globally distributed and ecologically important group of over 9,000 reptile species. The earliest fossil records are currently restricted to the Late Triassic and often dated to 227 million years ago (Mya). As these early records include taxa that are relatively d...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-13-208
更新日期:2013-09-25 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-018-1213-2
更新日期:2018-06-15 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-10-375
更新日期:2010-12-02 00:00:00
abstract:BACKGROUND:Bacteria occur in facultative association and intracellular symbiosis with a diversity of eukaryotic hosts. Recently, we have helped to characterise an intracellular nitrogen fixing bacterium, the so-called spheroid body, located within the diatom Rhopalodia gibba. Spheroid bodies are of cyanobacterial origi...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2008-01-28 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-11-361
更新日期:2011-12-16 00:00:00
abstract:BACKGROUND:RNA viruses evolve extremely quickly, allowing them to rapidly adapt to new environmental conditions. Viral pathogens, such as influenza virus, exploit this capacity for evolutionary change to persist within the human population despite substantial immune pressure. Understanding the process of adaptation in ...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2011-07-25 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-019-1527-8
更新日期:2019-11-06 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2010-07-27 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-016-0685-1
更新日期:2016-05-20 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-10-113
更新日期:2010-04-27 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-015-0469-z
更新日期:2015-09-03 00:00:00
abstract:BACKGROUND:Effects of polyploidisation on gene flow between natural populations are little known. Central European diploid and tetraploid populations of Arabidopsis arenosa and A. lyrata are here used to study interspecific and interploidal gene flow, using a combination of nuclear and plastid markers. RESULTS:Ploidal...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-11-346
更新日期:2011-11-29 00:00:00
abstract:BACKGROUND:Transposable elements (TE) have attracted much attention since they shape the genome and contribute to species evolution. Organisms have evolved mechanisms to control TE activity. Testis expressed 19 (Tex19) represses TE expression in mouse testis and placenta. In the human and mouse genomes, Tex19 and Secre...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-015-0506-y
更新日期:2015-10-12 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-11-335
更新日期:2011-11-17 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-8-244
更新日期:2008-09-02 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-016-0649-5
更新日期:2016-04-14 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-14-79
更新日期:2014-04-10 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-014-0250-8
更新日期:2014-12-12 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-11-20
更新日期:2011-01-20 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-30 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2148-12-220
更新日期:2012-11-16 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-11-330
更新日期:2011-11-15 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-018-1255-5
更新日期:2018-09-15 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/1471-2148-11-287
更新日期:2011-10-04 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-015-0504-0
更新日期:2015-10-21 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-019-1472-6
更新日期:2019-07-23 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2008-05-31 00:00:00
abstract::Following publication of the original article. ...
journal_title:BMC evolutionary biology
pub_type: 杂志文章,已发布勘误
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更新日期:2018-12-27 00:00:00
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
doi:10.1186/s12862-015-0372-7
更新日期:2015-05-13 00:00:00