Abstract:
:Placental fatty acid transport and metabolism are important for proper growth and development of the feto-placental unit. The nuclear receptors, liver X receptors alpha and beta (LXRalpha and LXRbeta), are key regulators of lipid metabolism in many tissues, but little is known about their role in fatty acid transport and metabolism in placenta. The current study investigates the LXR-mediated regulation of long-chain acyl-CoA synthetase 3 (ACSL3) and its functions in human placental trophoblast cells. We demonstrate that activation of LXR increases ACSL3 expression, acyl-CoA synthetase activity, and fatty acid uptake in human tropholast cells. Silencing of ACSL3 in these cells attenuates the LXR-mediated increase in acyl-CoA synthetase activity. Furthermore, we show that ACSL3 is directly regulated by LXR through a conserved LXR responsive element in the ACSL3 promoter. Our results suggest that LXR plays a regulatory role in fatty acid metabolism by direct regulation of ACSL3 in human placental trophoblast cells.
journal_name
J Lipid Resjournal_title
Journal of lipid researchauthors
Weedon-Fekjaer MS,Dalen KT,Solaas K,Staff AC,Duttaroy AK,Nebb HIdoi
10.1194/jlr.M004978subject
Has Abstractpub_date
2010-07-01 00:00:00pages
1886-96issue
7eissn
0022-2275issn
1539-7262pii
jlr.M004978journal_volume
51pub_type
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更新日期:2000-03-01 00:00:00
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:
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