Abstract:
:Standard therapeutic approaches of cytotoxics and radiation in cancer are not only highly toxic, but also of limited efficacy in treatment of a significant number of cancer patients. The molecular analysis of the cancer genomes have shown a remarkable complexity and pointed to key genomic and epigenomic alterations in cancer. These discoveries are paving the way for targeted therapy approaches. However, although there are a large number of potential targets, only a few can regulate key cellular functions and intersect multiple signaling networks. The Aurora kinase family members (A, B, and C) are a collection of highly related and conserved serine-threonine kinases that fulfill these criteria, being key regulators of mitosis and multiple signaling pathways. Alterations in Aurora kinase signaling are associated with mitotic errors and have been closely linked to chromosomal aneuploidy in cancer cells. Several studies have shown amplification and/or overexpression of Aurora kinase A and B in hematologic malignancies and solid tumors. Over the past several years, Aurora kinases have become attractive targets. Several ongoing clinical trials and bench-based research are assessing the unique therapeutic potential of Aurora-based targeted therapy.
journal_name
Mol Cancer Therjournal_title
Molecular cancer therapeuticsauthors
Dar AA,Goff LW,Majid S,Berlin J,El-Rifai Wdoi
10.1158/1535-7163.MCT-09-0765subject
Has Abstractpub_date
2010-02-01 00:00:00pages
268-78issue
2eissn
1535-7163issn
1538-8514pii
1535-7163.MCT-09-0765journal_volume
9pub_type
杂志文章,评审abstract::As the population ages, more elderly patients require radiotherapy-based treatment for their pelvic malignancies, including muscle-invasive bladder cancer, as they are unfit for major surgery. Therefore, there is an urgent need to find radiosensitizing agents minimally toxic to normal tissues, including bowel and blad...
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pub_type: 杂志文章,多中心研究
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更新日期:2020-02-01 00:00:00
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