Abstract:
:Neuroprotective therapy has been proposed for age-related neurodegenerative disorders, including Parkinson's disease. Inhibitors of type B monoamine oxidase (MAOB-Is), rasagiline and (-)deprenyl, are the most promising candidate neuroprotective drugs. Clinical trials of rasagiline in patients with Parkinson's disease suggest that rasagiline may have some disease-modifying effects. Results using animal and cellular models have proved that the MAOB-Is protect neurons by the intervention of 'intrinsic' mitochondrial apoptotic cascade and the induction of prosurvival antiapoptotic Bcl-2 and neurotrophic factors. Rasagiline-related MAOB-Is prevent mitochondrial permeability transition induced by various insults and activation of subsequent apoptotic cascades: cytochrome c release, casapase activation, and condensation and fragmentation of nuclear DNA. MAOB-Is increase transcription of prosurvival genes through activating the nuclear transcription factor-(NF) system. Rasagiline increases the protein and mRNA levels of GDNF in dopaminergic SH-SY5Y cells, whereas (-)deprenyl increases those of BDNF. Systemic administration of (-)deprenyl and rasagiline increases these neurotrophic factors in the cerebrospinal fluid from patients with Parkinson's disease and nonhuman primates. This review presents recent advances in our understanding of the neuroprotection offered by MAOB-Is and possible evaluation of neuroprotective efficacy in clinical samples is discussed.
journal_name
Expert Rev Neurotherjournal_title
Expert review of neurotherapeuticsauthors
Naoi M,Maruyama Wdoi
10.1586/ern.09.68subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1233-50issue
8eissn
1473-7175issn
1744-8360journal_volume
9pub_type
杂志文章abstract::This article reviews the potential uses of complementary and alternative medicine (CAM) techniques for individuals with mood disorders. Mood disorders are among the most prevalent mental health issues today and there are many approaches towards their management. While many different types of medication are available, ...
journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.2016.1135736
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章
doi:10.1586/ern.11.9
更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/ern.09.23
更新日期:2009-05-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章
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journal_title:Expert review of neurotherapeutics
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doi:10.1586/14737175.3.2.233
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1080/14737175.2017.1359088
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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journal_title:Expert review of neurotherapeutics
pub_type: 社论
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更新日期:2015-01-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.8.1.37
更新日期:2008-01-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.8.11.1691
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journal_title:Expert review of neurotherapeutics
pub_type:
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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更新日期:2006-09-01 00:00:00
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journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1080/14737175.2017.1253476
更新日期:2017-04-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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更新日期:2011-05-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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journal_title:Expert review of neurotherapeutics
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更新日期:2012-09-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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更新日期:2011-06-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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