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Using small molecules to dissect mechanisms of microbial pathogenesis.

Abstract：

:Understanding the ways in which pathogens invade and neutralize their hosts is of great interest from both an academic and a clinical perspective. However, in many cases genetic tools are unavailable or insufficient to fully characterize the detailed mechanisms of pathogenesis. Small molecule approaches are particularly powerful due to their ability to modulate specific biological functions in a highly controlled manner and their potential to broadly target conserved processes across species. Recently, two approaches that make use of small molecules, activity-based protein profiling and high-throughput phenotypic screening, have begun to find applications in the study of pathways involved in pathogenesis. In this Review we highlight ways in which these techniques have been applied to examine bacterial and parasitic pathogenesis and discuss possible ways in which these efforts can be expanded in the near future.

journal_name

ACS Chem Biol

journal_title

ACS chemical biology

authors

Puri AW,Bogyo M

doi

10.1021/cb9001409

subject

Has Abstract

pub_date

2009-08-21 00:00:00

pages

603-16

issue

8

eissn

1554-8929

issn

1554-8937

journal_volume

4

pub_type

杂志文章,评审

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