Growth patterns in children with sickle cell anemia during puberty.

Abstract:

BACKGROUND:Previous studies of children with homozygous sickle cell anemia (SCA) show impaired growth and maturation. The correlation of this suboptimal growth with metabolic and hematological factors during puberty is poorly understood. PROCEDURE:We studied a group of pre-adolescent children with SCA (19 males, 14 females) and healthy controls (16 males, 15 females) matched for race, sex, body size, and pubertal development. Height, weight, body mass index (BMI), and body composition changes were longitudinally assessed over a 2-year period and compared between the groups and with Z scores based on US growth charts. These changes were correlated with hemoglobin (Hgb) concentration and with energy expenditure (EE) measured using indirect whole-room calorimetry. RESULTS:Children with SCA progressed through puberty slower than control children. While, after 2 years, pubertal males with SCA were shorter, their annual increases in weight were not different from controls. The mean fat free mass (FFM) increments were significantly less in males and females with SCA than in control children. In males with SCA, growth in height declined over time and was significantly slower than in matched controls (P < 0.05). CONCLUSION:Growth delays were present during puberty in children with SCA. Decreased growth velocity in children with SCA was independently associated with decreased Hgb concentration and increased total EE.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Rhodes M,Akohoue SA,Shankar SM,Fleming I,Qi An A,Yu C,Acra S,Buchowski MS

doi

10.1002/pbc.22137

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

635-41

issue

4

eissn

1545-5009

issn

1545-5017

journal_volume

53

pub_type

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