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L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.

Abstract：

:A common dichotomy exists in inhibitor design: should the compounds be designed to block the enzymes of animals in the preclinical studies or to inhibit the human enzyme? We report that a single mutation of Leu-337 in rat neuronal nitric oxide synthase (nNOS) to His makes the enzyme resemble human nNOS more than rat nNOS. We expect that the approach used in this study can unite the dichotomy and speed up the process of inhibitor design and development.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Fang J,Ji H,Lawton GR,Xue F,Roman LJ,Silverman RB

doi

10.1021/jm900380j

subject

Has Abstract

pub_date

2009-07-23 00:00:00

pages

4533-7

issue

14

eissn

0022-2623

issn

1520-4804

journal_volume

52

pub_type

杂志文章

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