Abstract:
:Fragile X syndrome, a common form of inherited mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP). We have previously demonstrated that dFmr1, the Drosophila ortholog of the fragile X mental retardation 1 gene, plays a role in the proper maintenance of germline stem cells in Drosophila ovary; however, the molecular mechanism behind this remains elusive. In this study, we used an immunoprecipitation assay to reveal that specific microRNAs (miRNAs), particularly the bantam miRNA (bantam), are physically associated with dFmrp in ovary. We show that, like dFmr1, bantam is not only required for repressing primordial germ cell differentiation, it also functions as an extrinsic factor for germline stem cell maintenance. Furthermore, we find that bantam genetically interacts with dFmr1 to regulate the fate of germline stem cells. Collectively, our results support the notion that the FMRP-mediated translation pathway functions through specific miRNAs to control stem cell regulation.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Yang Y,Xu S,Xia L,Wang J,Wen S,Jin P,Chen Ddoi
10.1371/journal.pgen.1000444subject
Has Abstractpub_date
2009-04-01 00:00:00pages
e1000444issue
4eissn
1553-7390issn
1553-7404journal_volume
5pub_type
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