Genetics of pseudoexfoliation syndrome.

Abstract:

PURPOSE OF REVIEW:Pseudoexfoliation syndrome (XFS) is a late-onset and complex disorder that is strongly associated with the development of glaucoma. The purpose of this review is to discuss the inheritance patterns and recent genetic advances in the study of this disorder. RECENT FINDINGS:XFS has a strong familial association and recently, the lysyl oxidase-like 1 gene has been strongly associated with this disorder. This gene is involved in the synthesis and maintenance of elastic fibers and therefore has a strong biological rationale for being involved in this disorder. However, the exact relationship between lysyl oxidase-like 1 polymorphisms and the development of XFS has not been elucidated. Also, the value of genetic testing for this disorder has not been validated. SUMMARY:XFS is an important risk factor for glaucoma and lysyl oxidase-like 1 polymorphisms are strongly associated with XFS. The mechanisms behind glaucoma development and the value of genetic testing are not clear and further study is needed.

journal_name

Curr Opin Ophthalmol

authors

Challa P

doi

10.1097/ICU.0b013e328320d86a

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

88-91

issue

2

eissn

1040-8738

issn

1531-7021

pii

00055735-200903000-00005

journal_volume

20

pub_type

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