Qualitative and quantitative proteomic profiling of cripto(-/-) embryonic stem cells by means of accurate mass LC-MS analysis.

Abstract:

:Cripto is one of the key regulators of embryonic stem cells (ESCs) differentiation into cardiomyocites vs neuronal fate. Cripto(-/-) murine ESCs have been utilized to investigate the molecular mechanisms underlying early events of mammalian lineage differentiation. 2D/LC-MS/MS and a label-free LC-MS approaches were used to qualitatively and quantitatively profile the cripto(-/-) ESC proteome, providing an integral view of the alterations induced in stem cell functions by deleting the cripto gene.

journal_name

J Proteome Res

authors

Chambery A,Vissers JP,Langridge JI,Lonardo E,Minchiotti G,Ruvo M,Parente A

doi

10.1021/pr800485c

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

1047-58

issue

2

eissn

1535-3893

issn

1535-3907

pii

10.1021/pr800485c

journal_volume

8

pub_type

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