当前位置： SCI文献检索 > JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.

Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.

Abstract：

:A new quadruplex motif located in the promoter of the human KRAS gene, within a nuclease hypersensitive element (NHE), has been characterized. Oligonucleotides mimicking this quadruplex are found to compete with a DNA-protein complex between NHE and a nuclear extract from pancreatic cancer cells. When modified with (R)-1-O-[4-1-(1-pyrenylethynyl) phenylmethyl]glycerol insertions (TINA), the quadruplex oligonucleotides showed a dramatic increase of the T(m) (deltaT(m) from 22 to 32 degrees C) and a strong antiproliferative effects in Panc-1 cells.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Cogoi S,Paramasivam M,Filichev V,Géci I,Pedersen EB,Xodo LE

doi

10.1021/jm800874t

subject

Has Abstract

pub_date

2009-01-22 00:00:00

pages

564-8

issue

2

eissn

0022-2623

issn

1520-4804

pii

10.1021/jm800874t

journal_volume

52

pub_type

杂志文章

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