Abstract：
:The combination acetominophen/tramadol implies the use of two molecules which are different in the pharmacological structure but share a biological similarity in kinetics. Their respective actions are directed to different components of the nociceptive afference. Hematological clinical practice daily challenges diseases in with pain may be a very important symptom, ranging from acute leukemia to the common effects of certain chemotherapy regimens. Multiple myeloma gives one of the best example of a disease in which pain can be inflammatory (the compression of a nerve root) or neuropathic (demyelinating process) in origin. The use of acetaminophen/tramadol combination in the common ward or outward activity with myeloma patients indicates how it is possible to reach a good control of chronic pain with a minimum overlapping of the toxicities related to the primary disease as well as to the specific treatment. Furthermore, acetaminophen/tramadol combination is extremely useful also in those clinical situations in which a short term pain control is needed, particularly for the optimal safety profile.
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Cavazzini Fsubject
Has Abstractpub_date
2008-12-01 00:00:00pages
631-41issue
6eissn
0026-4806issn
1827-1669journal_volume
99pub_type
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