Abstract:
AIM:The aim of the study is to assess the feasibility of whole-body low-dose computed tomography (WBLDCT) in the diagnosis and staging of multiple myeloma and compare to skeletal survey (SS), using bone marrow biopsy and whole-body magnetic resonance imaging (WBMRI; where available) as gold standard. MATERIALS AND METHODS:Patients referred over an 18-month period for investigation of suspected multiple myeloma or restaging of myeloma were randomized to undergo one of two WBLDCT protocols using high kVp, low mAs technique (140 kVp, 14 mAs; or 140 kVp, 25 mAs). Recent WBMRI scans were reviewed in 23 cases. Each imaging modality was assessed by two radiologists in consensus and scored from 0-3 (0 = normal, 1 = 1-4 lesions, 2 = 5-20 lesions, 3 >or= 20 lesions/diffuse disease) in ten anatomical areas. Overall stage of disease, image quality score, and the degree of confidence of diagnosis were recorded. Diagnostic accuracy of skeletal survey and WBLDCT were determined using a gold standard of bone marrow biopsy and distribution of disease was compared to WBMRI. RESULTS:Thirty-nine patients were evaluated. WBLDCT identified more osteolytic lesions than skeletal survey with a greater degree of diagnostic confidence and led to restaging in 18 instances (16 upstaged, two downstaged). In those with recent WBMRI, distribution of disease on WBLDCT showed superior correlation with WBMRI when compared with SS. Overall reader impression of stage on WBLDCT showed significant correlation with WBMRI (kappa = 0.454, p < 0.05). WBLDCT provided complementary information to WBMRI in nine patients with normal marrow signal following treatment response, but which were shown to have diffuse residual cortical abnormalities on CT. CONCLUSION:WBLDCT at effective doses lower than previously reported, is superior to SS at detecting osteolytic lesions and at determining overall stage of multiple myeloma, and provides complementary information to WBMRI.
journal_name
Skeletal Radioljournal_title
Skeletal radiologyauthors
Gleeson TG,Moriarty J,Shortt CP,Gleeson JP,Fitzpatrick P,Byrne B,McHugh J,O'Connell M,O'Gorman P,Eustace SJdoi
10.1007/s00256-008-0607-4subject
Has Abstractpub_date
2009-03-01 00:00:00pages
225-36issue
3eissn
0364-2348issn
1432-2161journal_volume
38pub_type
杂志文章,随机对照试验abstract:PURPOSE:The purpose of this nested case-control study was to identify baseline, incident, and progressive MRI findings visible on standard MRI clinical sequences that were associated with development of incident knee pain in subjects at risk for OA over a period of 48 months. METHODS:We analyzed 60 case knees developi...
journal_title:Skeletal radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00256-016-2343-5
更新日期:2016-05-01 00:00:00
abstract::Muscle herniation can be defined as protrusion of a portion of muscle through an acquired or congenital defect of enclosing fascia. Although it is usually a cosmetic problem, it can lead to local pain and tenderness after prolonged exertion. In this report, we present a case of flexor digitorum superficialis muscle he...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-002-0615-8
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:The aim of this ex vivo study was to assess the performance of monoenergetic dual-energy CT (DECT) reconstructions to reduce metal artefacts in bodies with orthopedic devices in comparison with standard single-energy CT (SECT) examinations in forensic imaging. Forensic and clinical impacts of this study are ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-015-2155-z
更新日期:2015-09-01 00:00:00
abstract::Anatomical variants of muscle are commonly encountered by surgeons and radiologists. The flexor carpi radialis brevis (FCRB) is an anomalous muscle in the distal forearm with an estimated prevalence of 2-8%. In the literature, there are a few case reports of symptomatic FCRB tenosynovitis without a concomitant tear, a...
journal_title:Skeletal radiology
pub_type: 杂志文章,评审
doi:10.1007/s00256-018-2971-z
更新日期:2018-12-01 00:00:00
abstract::We report on a 9-year-old boy with metachronous aneurysmal bone cysts involving the tibia and pubis respectively. The patient has been clinically and radiographically followed for 3 years. ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s002560050288
更新日期:1997-09-01 00:00:00
abstract::Giant cell reparative granuloma (GCRG) is a non-neoplastic fibrous lesion with unevenly distributed multinucleated giant cells, areas of osseous metaplasia and hemorrhage. The small bones of the hands and feet are the most common sites, followed by the vertebral bodies and craniofacial bones. In the craniofacial bones...
journal_title:Skeletal radiology
pub_type: 杂志文章,评审
doi:10.1007/s00256-002-0563-3
更新日期:2003-03-01 00:00:00
abstract::Computed tomography is increasingly utilized for the evaluation of scaphoid fracture, nonunion, and deformity. We have developed a new technique of positioning patients while performing longitudinal computed tomography of the scaphoid. With the wrist positioned in radial deviation and neutral flexion, greater patient ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00198413
更新日期:1995-05-01 00:00:00
abstract::The radiomorphological appearance of fibrous metaphyseal defects (FMDs) is demonstrated by long-term follow-up studies. A characteristic radiomorphological course rather than a typical single appearance can be established. These findings correlate well with the duration of these tumor-like lesions; therefore, the radi...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00361448
更新日期:1988-01-01 00:00:00
abstract::We report the case of an 11-year-old boy who came to our observation with localized pain in the left arm for nearly 5 months. No previous history of trauma was referred in an otherwise healthy patient. Radiographs, isotope bone-scan, computed tomography, and magnetic resonance imaging of the lesion involving the left ...
journal_title:Skeletal radiology
pub_type: 杂志文章,评审
doi:10.1007/s00256-014-2039-7
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:Myxofibrosarcoma (MFS) is characterized by a high frequency of local recurrence after surgery because of infiltrative growth of the tumor cells. This infiltrative growth creates a characteristic 'tail-like' pattern on magnetic resonance imaging (MRI), and it has been reported that this pattern is especially o...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-014-1992-5
更新日期:2015-01-01 00:00:00
abstract::Nodular fasciitis is a benign rapidly proliferating fibrous tumor that is common in adults but relatively uncommon in children. When present in children, nodular fasciitis is typically subcutaneous in location and involves the head and neck. We present a case of intramuscular nodular fasciitis involving the rectus abd...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-012-1498-y
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To develop and validate a deep convolutional neural network (CNN) method capable of (1) selecting a specific shoulder sagittal MR image (Y-view) and (2) automatically segmenting rotator cuff (RC) muscles on a Y-view. We hypothesized a CNN approach can accurately perform both tasks compared with manual referen...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-020-03599-2
更新日期:2020-09-16 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of computed tomography (CT)-guided radiofrequency (RF) ablation for the treatment of osteoid osteomas in common and in technically challenging locations. MATERIALS AND METHODS:Twenty-three patients with osteoid osteomas in common (nine cases) and technically challenging [14 cases: in...
journal_title:Skeletal radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00256-009-0859-7
更新日期:2010-05-01 00:00:00
abstract::Lipoblastoma in the prepatellar region was observed in a 7-month-old girl. The diffuse (lipoblastomatosis) and circumscribed forms have different radiological appearances. Lobular proliferation of fatty tissue with fibrous septae is characteristic of the circumscribed form. ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF02341676
更新日期:1991-01-01 00:00:00
abstract::Tuberculosis remains a major international health problem despite advances in radiological diagnosis and antituberculous therapy. Disseminated tuberculous infection affecting a single bone and manifested as multifocal lytic cortical lesions is rare and unusual. We report on a 50-year-old man with multifocal involvemen...
journal_title:Skeletal radiology
pub_type: 杂志文章,评审
doi:10.1007/s00256-003-0714-1
更新日期:2004-04-01 00:00:00
abstract::While well-recognized in the orthopedic literature as a cause of chronic hip pain, acetabular retroversion has not been specifically described in the radiologic literature. Acetabular retroversion represents a particular form of hip dysplasia characterized by abnormal posterolateral orientation of the acetabulum. This...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-006-0150-0
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To investigate the behavior of the sciatic nerve during hip rotation at subgluteal space. MATERIALS AND METHODS:Sonographic examination (high-resolution ultrasound machine at 5.0-14 MHZ) of the gemelli-obturator internus complex following two approaches: (1) a study on cadavers and (2) a study on healthy vol...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-017-2831-2
更新日期:2018-06-01 00:00:00
abstract::We conducted a radiographic survey of 117 competitive water ski jumpers to determine whether this sport can cause spinal column damage and, if so, whether damage is more likely to occur in those who participate during the period of spinal growth and development (age 15 years or younger). We found a high prevalence of ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00357108
更新日期:1987-01-01 00:00:00
abstract::We report a case of liposarcoma in a 17-year-old boy in which both the radiographs and histology demonstrated multiple punctate calcifications. In addition, this unusual variant consisting of myxoid, round cell and well-differentiated liposarcoma behaved aggressively resulting in the death of the patient. ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-002-0561-5
更新日期:2002-11-01 00:00:00
abstract::A young girl had a large isolated and localized multicystic lesion of the right humerus, which was revealed by a pathological fracture. MRI and bone biopsy showed liquid-filled bone cysts. The final diagnosis was localized cystic lymphangiomatosis. ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00202161
更新日期:1995-10-01 00:00:00
abstract::Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder characterized by the reduced or absent activity of glucocerebrosidase. The disease is split into three types. Type 3, or chronic neuronopathic GD, manifests with heterogeneous clinical presentations. Skeletal manifestations of GD can include abn...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-011-1260-x
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Bone strength depends on both mineral content and bone structure. The aim of this in vitro study was to develop a method of quantitatively assessing trabecular bone structure by applying three-dimensional image processing to data acquired with multi-slice and cone-beam computed tomography using micro-computed...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-013-1766-5
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To evaluate anatomical variations in the lateral ankle and their relationships with pathological conditions of the peroneal tendon on magnetic resonance imaging (MRI) in symptomatic patients. MATERIALS AND METHODS:Sixty-nine ankles MRIs of 60 adult patients with symptomatic ankles were included. The presence...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-019-3151-5
更新日期:2019-08-01 00:00:00
abstract::Two patients with osteosarcoma of a lower limb and presumed lymph node metastases are described. The metastases presented in both children as palpable masses, one in the inguinal region and the other in the pelvis. One was visible on plain radiography; both were demonstrated on computed tomography and bone scintigraph...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00361209
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to describe a new technique called MR plastination arthrography to study both intra- and extra-articular anatomy. MATERIALS AND METHODS:In six human cadaveric lower legs MR arthrography was performed in either a one-step or two-step procedure. In the former a mixture of diluted Ga...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-008-0631-4
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:To identify radiological changes of the hands and feet in a large group of patients with Laurence-Moon-Bardet-Biedl syndrome. DESIGN:Postero-anterior views of hands and feet were obtained and analysed. PATIENTS:The material consists of 43 Scandinavian patients with the syndrome (24 males and 19 females; age...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s002560050153
更新日期:1996-10-01 00:00:00
abstract::A 15-year-old male presented with an 18-month history of increasing swelling on the radial aspect of his left forearm. Radiographs and MR images showed a partly calcified mass on the lateral border of the radius with erosion of the underlying cortex. Following a CT-guided needle biopsy, the mass was excised by segment...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s002560100347
更新日期:2001-05-01 00:00:00
abstract::A case report of bilateral ischial stress fractures in an elite tennis player initially mimicking hamstring pathology is described. This is an unusual site of stress fracture. Typical sites of stress fracture are well documented; however, awareness of less common sites of stress-related bone injury can aid early diagn...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-009-0687-9
更新日期:2009-07-01 00:00:00
abstract::Four cases of limb shortening presenting in childhood are described. All four children had been managed in a neonatal intensive care unit and had developed complications following the insertion of intravascular cannulae. In two, lower limb shortening and deformity were secondary to direct epiphyseal damage following e...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00241795
更新日期:1990-01-01 00:00:00
abstract::A 56-year-old man presented with a painless prepatellar mass of the left knee. MR images demonstrated a large, well-defined mass with heterogeneous intermediate signal intensity on T1- and proton density-weighted images. Mild, heterogeneous enhancement was noted after the intravenous administration of gadolinium. Diag...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-016-2494-4
更新日期:2016-12-01 00:00:00