Trabecular bone structure parameters from 3D image processing of clinical multi-slice and cone-beam computed tomography data.

Abstract:

OBJECTIVE:Bone strength depends on both mineral content and bone structure. The aim of this in vitro study was to develop a method of quantitatively assessing trabecular bone structure by applying three-dimensional image processing to data acquired with multi-slice and cone-beam computed tomography using micro-computed tomography as a reference. MATERIALS AND METHODS:Fifteen bone samples from the radius were examined. After segmentation, quantitative measures of bone volume, trabecular thickness, trabecular separation, trabecular number, trabecular nodes, and trabecular termini were obtained. RESULTS:The clinical machines overestimated bone volume and trabecular thickness and underestimated trabecular nodes and number, but cone-beam CT to a lesser extent. Parameters obtained from cone beam CT were strongly correlated with μCT, with correlation coefficients between 0.93 and 0.98 for all parameters except trabecular termini. CONCLUSIONS:The high correlation between cone-beam CT and micro-CT suggest the possibility of quantifying and monitoring changes of trabecular bone microarchitecture in vivo using cone beam CT.

journal_name

Skeletal Radiol

journal_title

Skeletal radiology

authors

Klintström E,Smedby O,Moreno R,Brismar TB

doi

10.1007/s00256-013-1766-5

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

197-204

issue

2

eissn

0364-2348

issn

1432-2161

journal_volume

43

pub_type

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