Abstract:
STUDY OBJECTIVE:Cervical cancer is a significant health problem in countries of the developing world. Although case series suggest advantages of total laparoscopic radical hysterectomy (TLRH) compared with total abdominal radical hysterectomy (TARH), no randomized controlled trial is currently available to establish TLRH as the new standard treatment. In this study, TLRH or total robotic radical hysterectomy (TRRH) will be performed without a vaginally assisted portion of the procedure. DESIGN:A biphasic randomized controlled trial was designed to test feasibility of recruitment and equivalence in regard to disease-free survival (Canadian Task Force classification I). SETTING:Tertiary referral hospital. PATIENTS:Patients with histologically confirmed invasive squamous cell carcinoma or adenocarcinoma of the cervix, stage IA1 (with lymphovascular space invasion), IA2, and IB1 are eligible. INTERVENTIONS:During the first phase, 100 patients will be randomized (1:1) to receive either TLRH/TRRH or TARH, with the primary end point being the rate of enrollment. During the second phase, recruitment will be extended by another 640 patients in a 1:1 TLRH/TRRH:TARH allocation, to determine equivalence with respect to disease-free survival with 80% power and alpha=0.05. MEASUREMENTS AND MAIN RESULTS:Equivalence will be assumed if the difference in disease-free survival does not exceed 7% at 4 years. Secondary outcomes include treatment-related morbidity, costs and cost effectiveness, patterns of recurrence, quality of life, pelvic floor function, feasibility of intraoperative sentinel node sampling, and overall survival. All data from this multicenter study will be entered using online electronic case report forms, allowing real-time assessment of data completeness and patient follow-up. CONCLUSION:This prospective trial aims to show the equivalence of a TLRH/TRRH versus TARH approach for patients with early stage cervical cancer following a 2-phase protocol. This trial was developed and designed with the input and approval of the members of the Gynecologic Oncology Committee from the American Association of Gynecologic Laparoscopists.
journal_name
J Minim Invasive Gynecoljournal_title
Journal of minimally invasive gynecologyauthors
Obermair A,Gebski V,Frumovitz M,Soliman PT,Schmeler KM,Levenback C,Ramirez PTdoi
10.1016/j.jmig.2008.06.013subject
Has Abstractpub_date
2008-09-01 00:00:00pages
584-8issue
5eissn
1553-4650issn
1553-4669pii
S1553-4650(08)00293-8journal_volume
15pub_type
杂志文章,多中心研究,随机对照试验abstract:STUDY OBJECTIVE:To evaluate the efficacy of intrauterine lidocaine instillation in reducing patient discomfort during saline solution infusion sonohysterography (SIS). DESIGN:A double-blinded, randomized, controlled trial (Canadian Task Force classification I). SETTING:Suleyman Demirel University School of Medicine, ...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jmig.2007.02.007
更新日期:2007-05-01 00:00:00
abstract:STUDY OBJECTIVE:To demonstrate stepwise techniques for the successful use of the laparoscopic single-site technique for safely performing transvaginal sacrocolpopexy for pelvic organ prolapse. DESIGN:Stepwise demonstration with narrated video footage (Canadian Task Force classification III). SETTING:Academic tertiary...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2020.11.018
更新日期:2020-11-26 00:00:00
abstract:STUDY OBJECTIVE:To compare surgical outcomes of laparoscopic hysterectomy for benign diseases according to the uterine weight. DESIGN:Retrospective study (Canadian Task Force classification II-3). SETTING:Teaching and research hospital, a tertiary center. PATIENTS:Women undergoing laparoscopic hysterectomy for benig...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2011.01.006
更新日期:2011-05-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the safety and efficacy of cold loop hysteroscopic myomectomy in a large series of cases. DESIGN:Retrospective study (Canadian Task Force Classification III). SETTING:Arbor Vitae Center for Endoscopic Gynecology, Rome, Italy. PATIENTS:A total of 1215 patients with 1 or more G1-G2 submucous ...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2015.03.004
更新日期:2015-07-01 00:00:00
abstract::Failed vesicovaginal fistula repairs are often considered complicated and are thus relegated to an abdominal approach using an interposition omental flap. We report our successful laparoscopic approach without use of an omental flap in a patient with multiple recurrences of a vesicovaginal fistula. ...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2012.08.768
更新日期:2012-11-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate the feasibility, safety, and short-term outcomes of robotic surgery (RS) for gynecologic oncologic indications (cervical, endometrial, and ovarian cancer) in elderly patients, especially women age 65 to 74 years (elderly group [EG]) compared with women age ≥75 years (very elderly group [V...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2018.01.007
更新日期:2018-01-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate the effectiveness of vasopressin in reducing blood loss in laparoscopic supracervical hysterectomy (LSH). DESIGN:Retrospective chart analysis (Canadian Task Force classification II-2). SETTING:University-affiliated teaching hospital. PATIENTS:In all, 143 women who had LSH for benign gy...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2007.12.002
更新日期:2008-03-01 00:00:00
abstract:STUDY OBJECTIVE:There are many instruments with different energy modalities or with different properties that are available for use in total laparoscopic hysterectomy. The aim of the study was to compare the use of LigaSure (Valleylab, Boulder, CO), HALO PKS cutting forceps (Gyrus-ACMI, Maple Grove, MA), and ENSEAL tis...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jmig.2014.01.010
更新日期:2014-07-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate the effects of hypoxia-inducible factor (HIF) inhibitors, flotation agents, barriers, and a surfactant on pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model. DESIGN:Prospective randomized trial (Canadian Task Force classification I). SETTING:Department of Obstetrics and G...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2007.04.002
更新日期:2007-09-01 00:00:00
abstract::Presacral and retrorectal space tumors are relatively rare lesions, the location of which can result in the onset of symptoms that are not well-defined. Retrorectal teratomas are resected to alleviate these symptoms and to rule out malignancy. Complete resection by one of the open abdominal or sacral approaches was tr...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2008.06.011
更新日期:2008-09-01 00:00:00
abstract:STUDY OBJECTIVE:To compare obstetric and surgical outcomes of transabdominal cerclage (TAC) via laparotomy (TAC-LAP) versus robotic-assisted (TAC-RA) approaches. DESIGN:Retrospective cohort study. SETTING:An academic medical center. PATIENTS:Sixty-nine women with acquired or congenital cervical insufficiency. INTER...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2019.08.014
更新日期:2020-01-01 00:00:00
abstract:STUDY OBJECTIVE:To review the changing trends in the surgical management of ectopic pregnancy and to evaluate the effect of an ongoing training program for resident surgeons on the rate and success of laparoscopic surgery. DESIGN:Retrospective chart review (Canadian Task Force classification II-3). SETTING:University...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2006.01.007
更新日期:2006-05-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate visual pattern parameters obtained with hysteroscopy for the prediction of endometrial cancer, to evaluate observer variation of these parameters, and to present a scoring system of the parameters for the prediction of malignancy compared with subjective evaluation. DESIGN:A prospective con...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2015.06.018
更新日期:2015-11-01 00:00:00
abstract::Laparoendoscopic single-site surgery (LESS) and natural orifice translumenal endoscopic surgery are now being used in gynecologic oncologic procedures. We used our expertise with LESS to perform nerve-sparing laparoscopic radical hysterectomy. A 45-year-old woman with stage IA2 cervical cancer was referred to us. The ...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2013.04.019
更新日期:2013-11-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the safety and short-term outcomes of laparoscopic subtotal hysterectomy using the PK and Lap Loop systems. DESIGN:Prospective observational study (Canadian Task Force classification II-2). SETTING:Princess Royal University and Chelsfield Park Hospitals, Kent, UK. PATIENTS:One hundred wom...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2005.05.007
更新日期:2005-07-01 00:00:00
abstract:STUDY OBJECTIVE:To determine whether pain, as part of an indication for global endometrial ablation, is an independent risk factor for failure. DESIGN:Retrospective cohort study (Canadian Task Force classification II-2). SETTING:Academic-affiliated community hospital. PATIENTS:Women undergoing global endometrial abl...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2018.01.020
更新日期:2018-01-01 00:00:00
abstract:STUDY OBJECTIVE:To examine whether our new reporting system and mandatory fluid-balance form could improve the communication and awareness within the surgical team and therefore the safety of hysteroscopic operations. DESIGN:A case-control study (Canadian Task Force classification II-2). SETTING:An endoscopic gynecol...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2017.06.014
更新日期:2017-01-01 00:00:00
abstract:STUDY OBJECTIVE:To study the effect of robotic surgery on the surgical approach to endometrial cancer in a gynecologic oncology center over a short time. DESIGN:Prospective analysis of patients with early-stage endometrial cancer who underwent robotic surgery. SETTING:Teaching hospital. PATIENTS:Eighty patients who ...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2009.03.013
更新日期:2009-07-01 00:00:00
abstract:STUDY OBJECTIVE:To compare perioperative and long-term outcomes related to laparoscopic and open abdominal surgical management of cervical cancer. DESIGN:Propensity-matched comparison of prospectively collected data (Canadian Task Force classification II-1). SETTING:University teaching hospital. PATIENTS:Sixty-five ...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2014.03.018
更新日期:2014-09-01 00:00:00
abstract:STUDY OBJECTIVE:Feasibility of laparoscopic extraperitoneal surgical staging for locally advanced cervical carcinoma in a gynecologic oncology fellowship training program. DESIGN:Retrospective analysis (II-2) of all patients who underwent laparoscopic extraperitoneal surgical staging at Women and Children's Hospital f...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2006.04.007
更新日期:2006-09-01 00:00:00
abstract:STUDY OBJECTIVES:The primary aim was to assess long-term effects of low-dose mifepristone on myoma regression, symptoms, and endometrial pathology. The secondary aim was to assess regrowth of myomas after cessation of mifepristone. DESIGN:Prospective, open-label, randomized, controlled trial of 5 mg versus 10 mg mifep...
journal_title:Journal of minimally invasive gynecology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.jmig.2005.01.022
更新日期:2005-05-01 00:00:00
abstract::Cornual pregnancy is an infrequent pathological condition with severe prognosis if not adequately recognized. Ipsilateral salpingectomy represents a unique risk factor for this clinical entity. This article reports a laparoscopically treated spontaneous cornual pregnancy after homolateral salpingectomy for an earlier ...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章,评审
doi:10.1016/j.jmig.2008.11.008
更新日期:2009-03-01 00:00:00
abstract:STUDY OBJECTIVE:To explore the feasibility and effectiveness of a modified posterior vaginal mesh suspension method in treating female rectocele with intractable constipation. DESIGN:Descriptive study (Canadian Task Force classification II-3). SETTING:The study was performed in the Study Center for Female Pelvic Dysf...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2012.06.004
更新日期:2012-11-01 00:00:00
abstract::A panel of experts in the field of endometriosis expressed their opinions on management options in a 35-year-old patient desiring pregnancy with a history of previous surgery for endometrioma and bowel obstruction symptoms. Many questions that this paradigmatic patient may pose to the clinician are addressed, and vari...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2015.01.021
更新日期:2015-05-01 00:00:00
abstract::Uterocutaneous fistula is a rare complication that may follow cesarean section. Herein is described a rare case of uterocutaneous fistula. The patient, a 28-year-old woman with a history of American Society for Reproductive Medicine stage IV endometriosis (Douglas pouch obliteration), underwent a cesarean section at 2...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2011.10.010
更新日期:2012-03-01 00:00:00
abstract::Splenic rupture is a rare and severe complication of laparoscopic surgery. We report a case of delayed splenic rupture as a severe complication of laparoscopy, occurring 5 days after surgery performed on a 52-year-old woman with history of abdominal surgery and with acute pelvic infection. Subcapsular hematoma, result...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2007.08.615
更新日期:2008-01-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate the factors associated with poorer oncologic outcomes in patients undergoing laparoscopic radical hysterectomy (LRH) for early stage cervical cancer. DESIGN:Multicenter retrospective study. SETTING:Three gynecologic oncology referral centers. PATIENTS:Patients with International Federa...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2020.04.015
更新日期:2021-01-01 00:00:00
abstract::A 69-year-old woman had a 4-year history of recurrent giant condylomas (Buschke-Lowenstein tumor) in the anal and perianal regions, with extension to the vulva and vagina. After failure of 3 surgical excisions, one of which was radical, the condition was successfully treated using carbon dioxide laser vaporization and...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2010.05.007
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:This study aimed to compare the risks of intraoperative and postoperative urologic complications after robotic radical hysterectomy (RRH) compared with laparoscopic radical hysterectomy (LRH). DATA SOURCES:We searched Pubmed, EMBASE, and the Cochrane Library for studies published up to March 2019. Related ar...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章,meta分析
doi:10.1016/j.jmig.2019.07.008
更新日期:2020-01-01 00:00:00
abstract::The most common mode of injury to the ureter is iatrogenic; however, injury during laparoscopic sterilization is rare. Although thermal ureteric injury during laparoscopic sterilization has been reported, to our knowledge, this is the first published report of ureteric injury caused by placement of a Filschie clip dur...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2009.01.011
更新日期:2009-05-01 00:00:00