Abstract:
STUDY OBJECTIVES:The primary aim was to assess long-term effects of low-dose mifepristone on myoma regression, symptoms, and endometrial pathology. The secondary aim was to assess regrowth of myomas after cessation of mifepristone. DESIGN:Prospective, open-label, randomized, controlled trial of 5 mg versus 10 mg mifepristone daily for 1 year, in women with large, symptomatic myomas, with variable follow-up among a subset of subjects (Canadian Task Force classification II-2). SETTING:University research group set in a community hospital. PATIENTS:Forty premenopausal women with large, symptomatic myomas. INTERVENTION:Oral mifepristone 5 or 10 mg daily for 1 year. MEASUREMENTS AND MAIN RESULTS:Mean uterine volumes decreased in both groups by 48% after 6 months of mifepristone and by 52% to 53 % in both groups after 12 months. Amenorrhea occurred in 61% to 65% at 6 months, and 40% to 70 % at 12 months. Eighty endometrial biopsies were performed. Simple hyperplasia was seen in 5 (13.9 %) of 36 subjects at 6 months and 1 (4.8 %) of 21 at 12 months. All cases of hyperplasia occurred in the 10 mg group. No endometrial sample showed cytologic atypia. Nine women were followed posttreatment for an average of 5.7 months. Uterine volumes increased among most of these subjects, although they remained on average 42% less than baseline. CONCLUSIONS:Long-term administration of low-dose mifepristone results in myoma shrinkage and amelioration of symptoms; modest rates of low-grade endometrial hyperplasia, but no evidence of premalignant potential, also occur. Regrowth occurs slowly following cessation of the drug.
journal_name
J Minim Invasive Gynecoljournal_title
Journal of minimally invasive gynecologyauthors
Eisinger SH,Bonfiglio T,Fiscella K,Meldrum S,Guzick DSdoi
10.1016/j.jmig.2005.01.022keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
227-33issue
3eissn
1553-4650issn
1553-4669pii
S1553-4650(05)00053-1journal_volume
12pub_type
临床试验,杂志文章,随机对照试验abstract:STUDY OBJECTIVE:To investigate the actual complication rate of hysteroscopic surgery performed by experienced endoscopic surgeons in a single medical center. DESIGN:A prospective descriptive study (Canadian Task Force classification III). SETTING:An endoscopic gynecology unit at a tertiary care university hospital. ...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2006.07.019
更新日期:2007-03-01 00:00:00
abstract:STUDY OBJECTIVE:To demonstrate the proper use of vessel-sealing devices during vaginal hysterectomy. DESIGN:Educational video (Canadian Task Force classification level III). SETTING:University hospital. INTERVENTION:The video reviews the principles on the use of energy in minimally invasive surgery. We focus on how ...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2018.04.018
更新日期:2019-02-01 00:00:00
abstract::Surgeons performing sophisticated endoscopic operations must be well versed in alternate laparoscopic access methods to address evolving patient expectations and safety requirements. The safety of left upper quadrant laparoscopic entry in patients with prior surgeries and abdominal adhesions was evaluated. Laparoscopi...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2004.12.026
更新日期:2005-01-01 00:00:00
abstract::Enhanced recovery after surgery (ERAS), or "fast-track" protocol, aims to minimize the physiologic stress of surgery and optimize the rehabilitation of patients. However, there is limited data in obstetrics and gynecology. We reviewed the published literature on ERAS programs in gynecology to evaluate the outcomes and...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2018.12.010
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To illustrate the laparoscopic surgical management of a particular localization of extrauterine pregnancy misdiagnosed until 12 weeks gestational age, complicated by hemoperitoneum and abortion. DESIGN:Canadian Task Force III on the Periodic Health Examination's Levels of Evidence. SETTING:The prevalence of...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2017.01.023
更新日期:2017-01-01 00:00:00
abstract::Vasopressin has been used in gynecologic surgery since the 1950s. Since its initial introduction, multiple applications of vasopressin have been explored. The expansion of vasopressin usage in gynecologic surgery is being fueled in part by the increase in minimally invasive surgical techniques, in which alternative me...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章,评审
doi:10.1016/j.jmig.2012.03.022
更新日期:2012-07-01 00:00:00
abstract::A 69-year-old woman had a 4-year history of recurrent giant condylomas (Buschke-Lowenstein tumor) in the anal and perianal regions, with extension to the vulva and vagina. After failure of 3 surgical excisions, one of which was radical, the condition was successfully treated using carbon dioxide laser vaporization and...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2010.05.007
更新日期:2010-09-01 00:00:00
abstract::Giant cervical polyps are characterized by an unusually large size and appear clinically as malignant. A 35-year-old woman had increased vaginal discharge and lower abdominal discomfort. At examination, a fist-sized, hard, consistent mass was found in the vagina. Pelvic magnetic resonance imaging revealed a 12.6 x 8-c...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2009.04.003
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:To perform a systematic review of the literature to identify best practices for nonhysteroscopic myomectomy for women with myomas who desire future fertility. The focus areas included factors associated with conception and pregnancy outcomes after myomectomy, impact of surgical route (laparotomic, laparoscopi...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章,评审
doi:10.1016/j.jmig.2020.10.006
更新日期:2020-10-14 00:00:00
abstract:STUDY OBJECTIVE:To assess the efficacy of prostaglandin F2α (PGF2α) in hysteroscopic myomectomy of submucous myomas. DESIGN:Single-blind, randomized clinical trial study. SETTING:Teaching hospital, affiliate of Iran University of Medical Sciences, Tehran, Iran. PATIENTS:Forty-four patients with symptomatic submucous...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2019.05.026
更新日期:2020-01-01 00:00:00
abstract::The primary goal of the clinical evaluation of abnormal uterine bleeding is to establish a specific diagnosis in the most efficient and least invasive manner possible. Hysteroscopy (HS) allows physicians to obtain directed biopsy in addition to direct visualization of the uterine cavity and lesions, but often requires...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2006.08.003
更新日期:2006-11-01 00:00:00
abstract:STUDY OBJECTIVE:To compare surgical outcomes of laparoscopic hysterectomy for benign diseases according to the uterine weight. DESIGN:Retrospective study (Canadian Task Force classification II-3). SETTING:Teaching and research hospital, a tertiary center. PATIENTS:Women undergoing laparoscopic hysterectomy for benig...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2011.01.006
更新日期:2011-05-01 00:00:00
abstract:STUDY OBJECTIVE:To show a new technique of using single-incision laparoscopic surgery (SILS) equipment in vaginal surgery to create a "pneumovagina." DESIGN:Explanatory video demonstrating the technique and intraoperative findings. SETTING:University hospital. PATIENT:The 68-year-old patient was referred with a vagi...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2017.04.001
更新日期:2017-01-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the efficacy and reproductive outcome of hysteroscopic removal of retained products of conception. DESIGN:Retrospective analysis (Canadian Task Force classification II-3). SETTING:Tertiary care university hospital. PATIENTS:One hundred fifty-nine patients were consecutively admitted to our ...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2010.09.001
更新日期:2011-01-01 00:00:00
abstract:STUDY OBJECTIVE:The effect of the different types of vaginal cuff closures on posthysterectomy sexual function has not been investigated in depth. We evaluated if there is a difference between transvaginal versus a laparoscopic closure after total laparoscopic hysterectomy (TLH) on female sexual function, using a valid...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jmig.2019.03.018
更新日期:2020-01-01 00:00:00
abstract::Uterine inversion is a rare obstetric emergency usually occurring in the immediate postpartum period after the third stage of labor. The incidence is reported to be between 1 in 550 to 1 in several thousand deliveries. Delayed postpartum uterine inversion is even less common, and may present a management challenge. We...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2009.12.003
更新日期:2010-03-01 00:00:00
abstract:STUDY OBJECTIVE:To describe the incidence of uterine vascular malformations (UVMs) including uterine arteriovenous malformations (AVMs) in patients after abortion or delivery and in outpatients. DESIGN:Prospective study (Canadian Task Force classification II-3). SETTING:Fukushima Red Cross Hospital. PATIENTS:Six pat...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2012.12.008
更新日期:2013-05-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate the effect of uterine weight on the mode of hysterectomy and on perioperative outcomes and to explore how the increasing experience in endoscopic techniques influenced our choice of surgical approach to hysterectomy to treat benign conditions. DESIGN:Retrospective analysis (Canadian Task...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2013.02.009
更新日期:2013-07-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate continuous (CON) compared with cyclic (CYC) administration of combined oral estroprogestins for 6 months after laparoscopic excision of ovarian endometriomas associated with pain. DESIGN:Multicenter, prospective, randomized trial (Canadian Task Force classification I). SETTING:Tertiary car...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jmig.2010.11.004
更新日期:2011-03-01 00:00:00
abstract::Diaphragm metastases in ovarian cancer can be safely resected robotically in selected patients. The technique is similar to laparotomy, whether it is a peritoneal or full-thickness excision. Trocar placement is very important for successful resection and is dependent on the location of the disease. Metastases involvin...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2019.12.018
更新日期:2020-01-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the rate of intrauterine adhesions after hysteroscopic resection of hyperplastic and/or cancer areas and the efficacy of combined treatment. DESIGN:Observational retrospective study. SETTING:Patients affected by endometrial atypical hyperplasia of the endometrium or early stage endometria...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2015.06.004
更新日期:2015-11-01 00:00:00
abstract:STUDY OBJECTIVE:To estimate the effectiveness of unidirectional knotless barbed suture and continuous suture with intracorporeal knots in the repair of uterine wall defects during laparoscopic myomectomy. DESIGN:Randomized clinical study (Canadian Task Force Classification I). SETTING:Single-center study in a univers...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jmig.2010.06.007
更新日期:2010-11-01 00:00:00
abstract::Hemangiomas are known to be common benign tumors. However, hemangiomas of female genital organs are very rare. Furthermore, a retroperitoneal hemangioma arising from ovarian vessels has never been reported. Here we report a case of a 29-year-old woman with a retroperitoneal cavernous hemangioma arising from the ovaria...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2009.07.017
更新日期:2009-11-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the 10-year subjective outcome of use of retropubic tension-free vaginal tape (TVT). DESIGN:Structured telephone interview (Canadian Task Force classification II-3). SETTING:Universitiy-affiliated tertiary medical center. PATIENTS:Sixty consecutive women with urodynamically confirmed stress...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2011.07.006
更新日期:2011-11-01 00:00:00
abstract:STUDY OBJECTIVE:To demonstrate a mesh-free laparoscopic uterosacral suture sacrohysteropexy (LUSSH). DESIGN:Technical video demonstrating LUSSH for uterine prolapse (Canadian Task Force classification III). SETTING:University hospital. PATIENT:A 37-year-old woman with grade 3 uterine descent requested uterine-sparin...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2018.03.025
更新日期:2019-02-01 00:00:00
abstract:STUDY OBJECTIVE:To develop a new hysteroscopic morphologic scoring system that helps physicians, especially those who have less experience, to make a differential diagnosis among normal endometrium (NE), endometrial hyperplasia, and endometrial carcinoma. DESIGN:A retrospective study (Canadian Task Force Classificatio...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2016.02.017
更新日期:2016-07-01 00:00:00
abstract::Adnexal masses are a common indication for surgery in the United States. This article reviews the clinical features that may suggest an underlying malignancy, including ultrasound and biomarkers. The decision regarding how to remove an adnexal mass involves consideration of several factors, including body habitus, int...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章,评审
doi:10.1016/j.jmig.2016.11.010
更新日期:2017-02-01 00:00:00
abstract::STUDY OBJECTIVE: To evaluate factors associated with the use of hemostatic agents during traditional laparoscopic or robotic hysterectomy. DESIGN:A retrospective cohort trial (Canadian Task Force classification III). SETTING:A single medical center in Cincinnati, OH, from August 1, 2013, to July 31, 2014. PATIENTS:...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2016.08.827
更新日期:2016-01-01 00:00:00
abstract:STUDY OBJECTIVE:We sought to estimate effectiveness of transdermal scopolamine to prevent postoperative nausea and vomiting after gynecologic laparoscopy. DESIGN:Patients were randomized to receive preoperative transdermal scopolamine or placebo. Main outcome measure was incidence of nausea during the first 24 hours p...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jmig.2007.08.616
更新日期:2008-01-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the effect of endometrial ablation on 6 premenstrual symptoms for up to 1 year after treatment. DESIGN:Prospective cohort of 59 women awaiting endometrial ablation (Canadian Task Force classification II-2). SETTING:University tertiary care hospital. PATIENTS:Adult women of childbearing ag...
journal_title:Journal of minimally invasive gynecology
pub_type: 杂志文章
doi:10.1016/j.jmig.2015.01.023
更新日期:2015-05-01 00:00:00